缺氧诱导因子1α异常表达对肝细胞癌血管生成的调控作用

肝细胞癌是我国常见恶性肿瘤之一,伴有血供丰富,传统疗法易导致耐受,患者预后极差。肝组织缺氧诱导因子（HIF）1α与百余种下游靶基因的缺氧反应元件联合,参与血管新生、糖代谢等过程,从而抑制癌细胞分化和凋亡,促进癌细胞增殖。HIF-1α的高表达,以及对血管生成相关因子的调控,与肝癌患者放、化疗耐受,易浸润、转移及预后相关。综述了肝癌细胞HIF-1α异常表达对血管生成相关因子的调控作用和相互关系。...

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Veröffentlicht in:	临床肝胆病杂志 2017, Vol.33 (2), p.369-374
1. Verfasser:	王理施维薛均潘璀然姚敏姚登福
Format:	Artikel
Sprache:	chi
Schlagworte:	癌,肝细胞综述缺氧诱导因子1 血管内皮生长因子类血管生成素2
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container_title	临床肝胆病杂志
container_volume	33
creator	王理施维薛均潘璀然姚敏姚登福
description	肝细胞癌是我国常见恶性肿瘤之一,伴有血供丰富,传统疗法易导致耐受,患者预后极差。肝组织缺氧诱导因子（HIF）1α与百余种下游靶基因的缺氧反应元件联合,参与血管新生、糖代谢等过程,从而抑制癌细胞分化和凋亡,促进癌细胞增殖。HIF-1α的高表达,以及对血管生成相关因子的调控,与肝癌患者放、化疗耐受,易浸润、转移及预后相关。综述了肝癌细胞HIF-1α异常表达对血管生成相关因子的调控作用和相互关系。
doi_str_mv	10.3969/j.issn.1001-5256.2017.02.037
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subjects	癌,肝细胞综述缺氧诱导因子1 血管内皮生长因子类血管生成素2
title	缺氧诱导因子1α异常表达对肝细胞癌血管生成的调控作用
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