Effect of minimally invasive surgery under anus and colonoscopy on pain stress, gastrointestinal hormones and vascular endothelial function in patients with rectal cancer

Effect of minimally invasive surgery under anus and colonoscopy on pain stress, gastrointestinal hormones and vascular endothelial function in patients with rectal cancer

Objective: To discuss the effects of minimally invasive surgery under transrectal anoscope on pain stress, gastrointestinal hormones and vascular endothelial function in patients with rectal cancer. Methods Totally 64 patients with rectal cancer who underwent minimally invasive surgery under transan...

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Veröffentlicht in:海南医科大学学报（英文版） 2019, Vol.25 (17), p.50-54
Hauptverfasser: YE Shao-Bing, LIU Gao, PU Zhi-Zhong, XIE Min
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creator YE Shao-Bing
LIU Gao
PU Zhi-Zhong
XIE Min
description Objective: To discuss the effects of minimally invasive surgery under transrectal anoscope on pain stress, gastrointestinal hormones and vascular endothelial function in patients with rectal cancer. Methods Totally 64 patients with rectal cancer who underwent minimally invasive surgery under transanal anastomosis from January 2017 to December 2018 in our hospital were selected as the observation group and the retrospective analysis of clinical data was conducted. Another 64 patients who underwent traditional laparotomy at the same time in our hospital were selected as the control group. Pain stress, gastrointestinal hormones, vascular endothelial function, and tumor marker changes were compared between the two groups. Results There were no significant differences in pain stress index, gastrointestinal hormone, vascular endothelial function index and tumor marker level between the two groups before operation (P>0.05). After operation, the levels of SP, BK and PGE2 in the two groups were higher than those before surgery (P
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Methods Totally 64 patients with rectal cancer who underwent minimally invasive surgery under transanal anastomosis from January 2017 to December 2018 in our hospital were selected as the observation group and the retrospective analysis of clinical data was conducted. Another 64 patients who underwent traditional laparotomy at the same time in our hospital were selected as the control group. Pain stress, gastrointestinal hormones, vascular endothelial function, and tumor marker changes were compared between the two groups. Results There were no significant differences in pain stress index, gastrointestinal hormone, vascular endothelial function index and tumor marker level between the two groups before operation (P&gt;0.05). After operation, the levels of SP, BK and PGE2 in the two groups were higher than those before surgery (P&lt;0.05), and the levels of GAS, MTL, VIP, VEGF, MMP-9, ET-1, CEA, CA724, CA125 and CA19-9 were higher with preoperative reduction of P&lt;0.05. The levels of SP, BK, PGE2, VEGF, MMP-9, ET-1, CEA, CA724, CA125 and CA19-9 in the observation group after operation were lower than those in the control group (P&lt;0.05), and the GAS, MTL and VIP levels were significantly higher than the control group (P&lt;0.05). Conclusion Minimally invasive surgery under transanal anoscope can reduce the pain stress of patients with rectal cancer, and the influence of gastrointestinal hormones is slight. It can effectively reduce the vascular endothelial function index and tumor marker level, help the immune function recovery of patients, and promote postoperative rehabilitation of patients.</description><identifier>ISSN: 1007-1237</identifier><language>eng</language><publisher>Department of General Surgery, Kaizhou People's Hospital, Chongqing 405400, China%Department of Anorectal Surgery, Kaizhou Anorectal Hospital, Chongqing 405400, China</publisher><ispartof>海南医科大学学报（英文版）, 2019, Vol.25 (17), p.50-54</ispartof><rights>Copyright © Wanfang Data Co. Ltd. All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.wanfangdata.com.cn/images/PeriodicalImages/hnykdxxb-e/hnykdxxb-e.jpg</thumbnail><link.rule.ids>314,776,780,4010</link.rule.ids></links><search><creatorcontrib>YE Shao-Bing</creatorcontrib><creatorcontrib>LIU Gao</creatorcontrib><creatorcontrib>PU Zhi-Zhong</creatorcontrib><creatorcontrib>XIE Min</creatorcontrib><title>Effect of minimally invasive surgery under anus and colonoscopy on pain stress, gastrointestinal hormones and vascular endothelial function in patients with rectal cancer</title><title>海南医科大学学报（英文版）</title><description>Objective: To discuss the effects of minimally invasive surgery under transrectal anoscope on pain stress, gastrointestinal hormones and vascular endothelial function in patients with rectal cancer. Methods Totally 64 patients with rectal cancer who underwent minimally invasive surgery under transanal anastomosis from January 2017 to December 2018 in our hospital were selected as the observation group and the retrospective analysis of clinical data was conducted. Another 64 patients who underwent traditional laparotomy at the same time in our hospital were selected as the control group. Pain stress, gastrointestinal hormones, vascular endothelial function, and tumor marker changes were compared between the two groups. Results There were no significant differences in pain stress index, gastrointestinal hormone, vascular endothelial function index and tumor marker level between the two groups before operation (P&gt;0.05). After operation, the levels of SP, BK and PGE2 in the two groups were higher than those before surgery (P&lt;0.05), and the levels of GAS, MTL, VIP, VEGF, MMP-9, ET-1, CEA, CA724, CA125 and CA19-9 were higher with preoperative reduction of P&lt;0.05. The levels of SP, BK, PGE2, VEGF, MMP-9, ET-1, CEA, CA724, CA125 and CA19-9 in the observation group after operation were lower than those in the control group (P&lt;0.05), and the GAS, MTL and VIP levels were significantly higher than the control group (P&lt;0.05). Conclusion Minimally invasive surgery under transanal anoscope can reduce the pain stress of patients with rectal cancer, and the influence of gastrointestinal hormones is slight. It can effectively reduce the vascular endothelial function index and tumor marker level, help the immune function recovery of patients, and promote postoperative rehabilitation of patients.</description><issn>1007-1237</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNqVjkFOAzEMRWcBEhX0Dt5DpUlHKGWNijgA-1GacWZMM3YVJ23nSpySILgAG38vnt_3TbMybWs3ZtvZu2atSof22XS2s3a3ar72IaDPIAFmYppdjAsQn53SGUFLGjEtUHjABI6L1jGAlygs6uW0gDCcHDFoTqj6BKOrmxBn1EzsIkySZmH8vaxeX6JLgDxInjBSJUJhn6mK6MeVCTkrXChPkOprFfCOPaaH5ja4qLj-y_vm8W3_8fq-uTgOjsf-U0qqjdpPvByH6_XQ47Y1L8a2xnT_o78BEklpPw</recordid><startdate>2019</startdate><enddate>2019</enddate><creator>YE Shao-Bing</creator><creator>LIU Gao</creator><creator>PU Zhi-Zhong</creator><creator>XIE Min</creator><general>Department of General Surgery, Kaizhou People's Hospital, Chongqing 405400, China%Department of Anorectal Surgery, Kaizhou Anorectal Hospital, Chongqing 405400, China</general><scope>2B.</scope><scope>4A8</scope><scope>92I</scope><scope>93N</scope><scope>PSX</scope><scope>TCJ</scope></search><sort><creationdate>2019</creationdate><title>Effect of minimally invasive surgery under anus and colonoscopy on pain stress, gastrointestinal hormones and vascular endothelial function in patients with rectal cancer</title><author>YE Shao-Bing ; LIU Gao ; PU Zhi-Zhong ; XIE Min</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-wanfang_journals_hnykdxxb_e2019170113</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>YE Shao-Bing</creatorcontrib><creatorcontrib>LIU Gao</creatorcontrib><creatorcontrib>PU Zhi-Zhong</creatorcontrib><creatorcontrib>XIE Min</creatorcontrib><collection>Wanfang Data Journals - Hong Kong</collection><collection>WANFANG Data Centre</collection><collection>Wanfang Data Journals</collection><collection>万方数据期刊 - 香港版</collection><collection>China Online Journals (COJ)</collection><collection>China Online Journals (COJ)</collection><jtitle>海南医科大学学报（英文版）</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>YE Shao-Bing</au><au>LIU Gao</au><au>PU Zhi-Zhong</au><au>XIE Min</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of minimally invasive surgery under anus and colonoscopy on pain stress, gastrointestinal hormones and vascular endothelial function in patients with rectal cancer</atitle><jtitle>海南医科大学学报（英文版）</jtitle><date>2019</date><risdate>2019</risdate><volume>25</volume><issue>17</issue><spage>50</spage><epage>54</epage><pages>50-54</pages><issn>1007-1237</issn><abstract>Objective: To discuss the effects of minimally invasive surgery under transrectal anoscope on pain stress, gastrointestinal hormones and vascular endothelial function in patients with rectal cancer. Methods Totally 64 patients with rectal cancer who underwent minimally invasive surgery under transanal anastomosis from January 2017 to December 2018 in our hospital were selected as the observation group and the retrospective analysis of clinical data was conducted. Another 64 patients who underwent traditional laparotomy at the same time in our hospital were selected as the control group. Pain stress, gastrointestinal hormones, vascular endothelial function, and tumor marker changes were compared between the two groups. Results There were no significant differences in pain stress index, gastrointestinal hormone, vascular endothelial function index and tumor marker level between the two groups before operation (P&gt;0.05). After operation, the levels of SP, BK and PGE2 in the two groups were higher than those before surgery (P&lt;0.05), and the levels of GAS, MTL, VIP, VEGF, MMP-9, ET-1, CEA, CA724, CA125 and CA19-9 were higher with preoperative reduction of P&lt;0.05. The levels of SP, BK, PGE2, VEGF, MMP-9, ET-1, CEA, CA724, CA125 and CA19-9 in the observation group after operation were lower than those in the control group (P&lt;0.05), and the GAS, MTL and VIP levels were significantly higher than the control group (P&lt;0.05). Conclusion Minimally invasive surgery under transanal anoscope can reduce the pain stress of patients with rectal cancer, and the influence of gastrointestinal hormones is slight. It can effectively reduce the vascular endothelial function index and tumor marker level, help the immune function recovery of patients, and promote postoperative rehabilitation of patients.</abstract><pub>Department of General Surgery, Kaizhou People's Hospital, Chongqing 405400, China%Department of Anorectal Surgery, Kaizhou Anorectal Hospital, Chongqing 405400, China</pub></addata></record>
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title Effect of minimally invasive surgery under anus and colonoscopy on pain stress, gastrointestinal hormones and vascular endothelial function in patients with rectal cancer
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