Effect of exercise rehabilitation combined with trimetazidine on endothelial function, inflammatory response and blood lipid metabolism in patients with coronary heart disease after PCI
Objective:To study the effect of exercise rehabilitation combined with trimetazidine on endothelial function, inflammatory response and blood lipid metabolism in patients with coronary heart disease after percutaneous coronary intervention (PCI).Methods: The patients with stable angina pectoris who...
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| Veröffentlicht in: | 海南医科大学学报（英文版） 2019, Vol.25 (2), p.28-32 |
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| creator | Li-Li Wang Yu-Mei He A-Ning Zhang |
| description | Objective:To study the effect of exercise rehabilitation combined with trimetazidine on endothelial function, inflammatory response and blood lipid metabolism in patients with coronary heart disease after percutaneous coronary intervention (PCI).Methods: The patients with stable angina pectoris who received PCI in our hospital between July 2015 and November 2017 were chosen and randomly divided into the observation group who received postoperative exercise rehabilitation combined with trimetazidine and the control group who received conventional intervention combined with trimetazidine. The reactive hyperemia index (RHI) as well as serum contents of endothelial markers, inflammatory cytokines and blood lipid indexes were determined before intervention and after intervention for 3 months.Results:After intervention for 3 months, the RHI levels as well as serum NO, HDL-C and Omentin-1 contents of both groups significantly increased while serum ET-1, vWF, M-CSF, IL-6, IL-8, RANTES, LDL-C and Chemerin contents significantly decreased; the RHI level as well as serum NO, HDL-C and Omentin-1 contents of the observation group was significantly higher than those of the control group while serum ET-1, vWF, M-CSF, IL-6, IL-8, RANTES, LDL-C and Chemerin contents were significantly lower than those of the control group.Conclusion:Exercise rehabilitation combined with trimetazidine can improve the endothelial function, inhibit the inflammatory response and regulate the blood lipid metabolism in patients with coronary heart disease after PCI. |
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The reactive hyperemia index (RHI) as well as serum contents of endothelial markers, inflammatory cytokines and blood lipid indexes were determined before intervention and after intervention for 3 months.Results:After intervention for 3 months, the RHI levels as well as serum NO, HDL-C and Omentin-1 contents of both groups significantly increased while serum ET-1, vWF, M-CSF, IL-6, IL-8, RANTES, LDL-C and Chemerin contents significantly decreased; the RHI level as well as serum NO, HDL-C and Omentin-1 contents of the observation group was significantly higher than those of the control group while serum ET-1, vWF, M-CSF, IL-6, IL-8, RANTES, LDL-C and Chemerin contents were significantly lower than those of the control group.Conclusion:Exercise rehabilitation combined with trimetazidine can improve the endothelial function, inhibit the inflammatory response and regulate the blood lipid metabolism in patients with coronary heart disease after PCI.</description><identifier>ISSN: 1007-1237</identifier><language>eng</language><publisher>Department of General Medicine, Dongguan Branch, Yan'an University Affiliated Hospital, Yan'an, Shaanxi Province, 716000%Neurology Department, Dongguan Branch, Yan'an University Affiliated Hospital, Yan'an, Shaanxi Province, 716000</publisher><ispartof>海南医科大学学报（英文版）, 2019, Vol.25 (2), p.28-32</ispartof><rights>Copyright © Wanfang Data Co. Ltd. All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.wanfangdata.com.cn/images/PeriodicalImages/hnykdxxb-e/hnykdxxb-e.jpg</thumbnail><link.rule.ids>314,780,784,4024</link.rule.ids></links><search><creatorcontrib>Li-Li Wang</creatorcontrib><creatorcontrib>Yu-Mei He</creatorcontrib><creatorcontrib>A-Ning Zhang</creatorcontrib><title>Effect of exercise rehabilitation combined with trimetazidine on endothelial function, inflammatory response and blood lipid metabolism in patients with coronary heart disease after PCI</title><title>海南医科大学学报（英文版）</title><description>Objective:To study the effect of exercise rehabilitation combined with trimetazidine on endothelial function, inflammatory response and blood lipid metabolism in patients with coronary heart disease after percutaneous coronary intervention (PCI).Methods: The patients with stable angina pectoris who received PCI in our hospital between July 2015 and November 2017 were chosen and randomly divided into the observation group who received postoperative exercise rehabilitation combined with trimetazidine and the control group who received conventional intervention combined with trimetazidine. The reactive hyperemia index (RHI) as well as serum contents of endothelial markers, inflammatory cytokines and blood lipid indexes were determined before intervention and after intervention for 3 months.Results:After intervention for 3 months, the RHI levels as well as serum NO, HDL-C and Omentin-1 contents of both groups significantly increased while serum ET-1, vWF, M-CSF, IL-6, IL-8, RANTES, LDL-C and Chemerin contents significantly decreased; the RHI level as well as serum NO, HDL-C and Omentin-1 contents of the observation group was significantly higher than those of the control group while serum ET-1, vWF, M-CSF, IL-6, IL-8, RANTES, LDL-C and Chemerin contents were significantly lower than those of the control group.Conclusion:Exercise rehabilitation combined with trimetazidine can improve the endothelial function, inhibit the inflammatory response and regulate the blood lipid metabolism in patients with coronary heart disease after PCI.</description><issn>1007-1237</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNqVkE1OxDAMhbsAiRHMHbyHkfojVFiPBsGOBfvKaRxiSO0qyWg63IzbkQouwMqSn9_3nnxRbZq67ndN2_VX1TYlNvV90_Vd3z9squ-DczRmUAe0UBw5EUTyaDhwxswqMOpkWMjCibOHHHmijF9syw6KTGI1ewqMAdxRxtVzBywu4DRh1nguwDSrFDKKBRNULQSe2cJKMho4TcUAc8kjyek3aNSogsXtCWMGW5rhinCZIrzuX26qS4ch0fZvXle3T4e3_fPuhOJQ3ocPPUYpyuDl_GmXxQzU1s1j3ZZvdP-7_gGaxm5b</recordid><startdate>2019</startdate><enddate>2019</enddate><creator>Li-Li Wang</creator><creator>Yu-Mei He</creator><creator>A-Ning Zhang</creator><general>Department of General Medicine, Dongguan Branch, Yan'an University Affiliated Hospital, Yan'an, Shaanxi Province, 716000%Neurology Department, Dongguan Branch, Yan'an University Affiliated Hospital, Yan'an, Shaanxi Province, 716000</general><scope>2B.</scope><scope>4A8</scope><scope>92I</scope><scope>93N</scope><scope>PSX</scope><scope>TCJ</scope></search><sort><creationdate>2019</creationdate><title>Effect of exercise rehabilitation combined with trimetazidine on endothelial function, inflammatory response and blood lipid metabolism in patients with coronary heart disease after PCI</title><author>Li-Li Wang ; Yu-Mei He ; A-Ning Zhang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-wanfang_journals_hnykdxxb_e2019020073</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li-Li Wang</creatorcontrib><creatorcontrib>Yu-Mei He</creatorcontrib><creatorcontrib>A-Ning Zhang</creatorcontrib><collection>Wanfang Data Journals - Hong Kong</collection><collection>WANFANG Data Centre</collection><collection>Wanfang Data Journals</collection><collection>万方数据期刊 - 香港版</collection><collection>China Online Journals (COJ)</collection><collection>China Online Journals (COJ)</collection><jtitle>海南医科大学学报（英文版）</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li-Li Wang</au><au>Yu-Mei He</au><au>A-Ning Zhang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of exercise rehabilitation combined with trimetazidine on endothelial function, inflammatory response and blood lipid metabolism in patients with coronary heart disease after PCI</atitle><jtitle>海南医科大学学报（英文版）</jtitle><date>2019</date><risdate>2019</risdate><volume>25</volume><issue>2</issue><spage>28</spage><epage>32</epage><pages>28-32</pages><issn>1007-1237</issn><abstract>Objective:To study the effect of exercise rehabilitation combined with trimetazidine on endothelial function, inflammatory response and blood lipid metabolism in patients with coronary heart disease after percutaneous coronary intervention (PCI).Methods: The patients with stable angina pectoris who received PCI in our hospital between July 2015 and November 2017 were chosen and randomly divided into the observation group who received postoperative exercise rehabilitation combined with trimetazidine and the control group who received conventional intervention combined with trimetazidine. The reactive hyperemia index (RHI) as well as serum contents of endothelial markers, inflammatory cytokines and blood lipid indexes were determined before intervention and after intervention for 3 months.Results:After intervention for 3 months, the RHI levels as well as serum NO, HDL-C and Omentin-1 contents of both groups significantly increased while serum ET-1, vWF, M-CSF, IL-6, IL-8, RANTES, LDL-C and Chemerin contents significantly decreased; the RHI level as well as serum NO, HDL-C and Omentin-1 contents of the observation group was significantly higher than those of the control group while serum ET-1, vWF, M-CSF, IL-6, IL-8, RANTES, LDL-C and Chemerin contents were significantly lower than those of the control group.Conclusion:Exercise rehabilitation combined with trimetazidine can improve the endothelial function, inhibit the inflammatory response and regulate the blood lipid metabolism in patients with coronary heart disease after PCI.</abstract><pub>Department of General Medicine, Dongguan Branch, Yan'an University Affiliated Hospital, Yan'an, Shaanxi Province, 716000%Neurology Department, Dongguan Branch, Yan'an University Affiliated Hospital, Yan'an, Shaanxi Province, 716000</pub></addata></record> |
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| identifier | ISSN: 1007-1237 |
| ispartof | 海南医科大学学报（英文版）, 2019, Vol.25 (2), p.28-32 |
| issn | 1007-1237 |
| language | eng |
| recordid | cdi_wanfang_journals_hnykdxxb_e201902007 |
| source | Alma/SFX Local Collection |
| title | Effect of exercise rehabilitation combined with trimetazidine on endothelial function, inflammatory response and blood lipid metabolism in patients with coronary heart disease after PCI |
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