Effects of octreotide combined with gabexate on related cytokines in patients with severe acute pancreatitis

Effects of octreotide combined with gabexate on related cytokines in patients with severe acute pancreatitis

Objective:To study the effects of octreotide combined with gabexate on related cytokines in patients with severe acute pancreatitis (SAP).Methods:A total of 92 patients with SAP from January 2014 to December 2017 in our hospital were enrolled in this study. According to random number table method, t...

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Veröffentlicht in:海南医科大学学报（英文版） 2018, Vol.24 (16), p.38-41
Hauptverfasser: Xiao-Ming Huang, Yan Zhou, Qiu-Peng Feng, Min-Xue Yao, Ying-Xin Wang
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container_title 海南医科大学学报（英文版）
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creator Xiao-Ming Huang
Yan Zhou
Qiu-Peng Feng
Min-Xue Yao
Ying-Xin Wang
description Objective:To study the effects of octreotide combined with gabexate on related cytokines in patients with severe acute pancreatitis (SAP).Methods:A total of 92 patients with SAP from January 2014 to December 2017 in our hospital were enrolled in this study. According to random number table method, the patients were divided into the control group and the treatment group, each groups has 46 patients. The control group were treated with octreotide, the treatment group were treated with octreotide combined with gabexate. To compare the serum B7-H3, PCT, sICAM-1, NF-κB, sTREM-1, BAFF, SAA, NGAL, ghrelin, hs-CRP, MDA and SOD of the two groups before and after treatment.Results: The serum B7-H3, PCT, sICAM-1, NF-κB, sTREM-1, BAFF, SAA, NGAL, ghrelin, hs-CRP, MDA and SOD of the two groups before treatment have no no significantly differences. The serum B7-H3, PCT, sICAM-1, NF-κB, sTREM-1, BAFF, SAA, NGAL, ghrelin, hs-CRP, MDA of the two groups after treatment were significantly lower than before treatment, the serum SOD of the two groups after treatment were significantly better than before treatment, and that of the treatment group were significantly better than the control group after treatment.Conclusion: Octreotide combined with gabexate for patients with SAP can reduce the serum B7-H3, PCT, sICAM-1, NF-κB, sTREM-1, BAFF, SAA, NGAL, ghrelin, hs-CRP, MDA levels, improve serum SOD levels, and it was worthy clinical application.
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According to random number table method, the patients were divided into the control group and the treatment group, each groups has 46 patients. The control group were treated with octreotide, the treatment group were treated with octreotide combined with gabexate. To compare the serum B7-H3, PCT, sICAM-1, NF-κB, sTREM-1, BAFF, SAA, NGAL, ghrelin, hs-CRP, MDA and SOD of the two groups before and after treatment.Results: The serum B7-H3, PCT, sICAM-1, NF-κB, sTREM-1, BAFF, SAA, NGAL, ghrelin, hs-CRP, MDA and SOD of the two groups before treatment have no no significantly differences. The serum B7-H3, PCT, sICAM-1, NF-κB, sTREM-1, BAFF, SAA, NGAL, ghrelin, hs-CRP, MDA of the two groups after treatment were significantly lower than before treatment, the serum SOD of the two groups after treatment were significantly better than before treatment, and that of the treatment group were significantly better than the control group after treatment.Conclusion: Octreotide combined with gabexate for patients with SAP can reduce the serum B7-H3, PCT, sICAM-1, NF-κB, sTREM-1, BAFF, SAA, NGAL, ghrelin, hs-CRP, MDA levels, improve serum SOD levels, and it was worthy clinical application.</description><identifier>ISSN: 1007-1237</identifier><language>eng</language><publisher>Emergency Medicine Department, First people's Hospital of Kunshan, Kunshan 215300 China</publisher><ispartof>海南医科大学学报（英文版）, 2018, Vol.24 (16), p.38-41</ispartof><rights>Copyright © Wanfang Data Co. Ltd. All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.wanfangdata.com.cn/images/PeriodicalImages/hnykdxxb-e/hnykdxxb-e.jpg</thumbnail><link.rule.ids>314,780,784,4024</link.rule.ids></links><search><creatorcontrib>Xiao-Ming Huang</creatorcontrib><creatorcontrib>Yan Zhou</creatorcontrib><creatorcontrib>Qiu-Peng Feng</creatorcontrib><creatorcontrib>Min-Xue Yao</creatorcontrib><creatorcontrib>Ying-Xin Wang</creatorcontrib><title>Effects of octreotide combined with gabexate on related cytokines in patients with severe acute pancreatitis</title><title>海南医科大学学报（英文版）</title><description>Objective:To study the effects of octreotide combined with gabexate on related cytokines in patients with severe acute pancreatitis (SAP).Methods:A total of 92 patients with SAP from January 2014 to December 2017 in our hospital were enrolled in this study. According to random number table method, the patients were divided into the control group and the treatment group, each groups has 46 patients. The control group were treated with octreotide, the treatment group were treated with octreotide combined with gabexate. To compare the serum B7-H3, PCT, sICAM-1, NF-κB, sTREM-1, BAFF, SAA, NGAL, ghrelin, hs-CRP, MDA and SOD of the two groups before and after treatment.Results: The serum B7-H3, PCT, sICAM-1, NF-κB, sTREM-1, BAFF, SAA, NGAL, ghrelin, hs-CRP, MDA and SOD of the two groups before treatment have no no significantly differences. The serum B7-H3, PCT, sICAM-1, NF-κB, sTREM-1, BAFF, SAA, NGAL, ghrelin, hs-CRP, MDA of the two groups after treatment were significantly lower than before treatment, the serum SOD of the two groups after treatment were significantly better than before treatment, and that of the treatment group were significantly better than the control group after treatment.Conclusion: Octreotide combined with gabexate for patients with SAP can reduce the serum B7-H3, PCT, sICAM-1, NF-κB, sTREM-1, BAFF, SAA, NGAL, ghrelin, hs-CRP, MDA levels, improve serum SOD levels, and it was worthy clinical application.</description><issn>1007-1237</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNqVjE0KwjAUhLNQULR3eHsREoume1E8gPuSnxeNrS8liVpvbxAv4GoGvm9mwuaCc7kWm1rOWJWS13wrallL2cxZf3AOTU4QHASTI4bsLYIJd-0JLbx8vsJFaRxVRggEEfvSLJh3Dl1REniCQWWPVF6-esInRgRlHmUyKDIRC88-LdnUqT5h9csFWx0P5_1p_VLkFF3aW3hEKqS90ruz46hb3HDRiB0XvP7P_gBWmVEh</recordid><startdate>2018</startdate><enddate>2018</enddate><creator>Xiao-Ming Huang</creator><creator>Yan Zhou</creator><creator>Qiu-Peng Feng</creator><creator>Min-Xue Yao</creator><creator>Ying-Xin Wang</creator><general>Emergency Medicine Department, First people's Hospital of Kunshan, Kunshan 215300 China</general><scope>2B.</scope><scope>4A8</scope><scope>92I</scope><scope>93N</scope><scope>PSX</scope><scope>TCJ</scope></search><sort><creationdate>2018</creationdate><title>Effects of octreotide combined with gabexate on related cytokines in patients with severe acute pancreatitis</title><author>Xiao-Ming Huang ; Yan Zhou ; Qiu-Peng Feng ; Min-Xue Yao ; Ying-Xin Wang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-wanfang_journals_hnykdxxb_e2018160103</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Xiao-Ming Huang</creatorcontrib><creatorcontrib>Yan Zhou</creatorcontrib><creatorcontrib>Qiu-Peng Feng</creatorcontrib><creatorcontrib>Min-Xue Yao</creatorcontrib><creatorcontrib>Ying-Xin Wang</creatorcontrib><collection>Wanfang Data Journals - Hong Kong</collection><collection>WANFANG Data Centre</collection><collection>Wanfang Data Journals</collection><collection>万方数据期刊 - 香港版</collection><collection>China Online Journals (COJ)</collection><collection>China Online Journals (COJ)</collection><jtitle>海南医科大学学报（英文版）</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Xiao-Ming Huang</au><au>Yan Zhou</au><au>Qiu-Peng Feng</au><au>Min-Xue Yao</au><au>Ying-Xin Wang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of octreotide combined with gabexate on related cytokines in patients with severe acute pancreatitis</atitle><jtitle>海南医科大学学报（英文版）</jtitle><date>2018</date><risdate>2018</risdate><volume>24</volume><issue>16</issue><spage>38</spage><epage>41</epage><pages>38-41</pages><issn>1007-1237</issn><abstract>Objective:To study the effects of octreotide combined with gabexate on related cytokines in patients with severe acute pancreatitis (SAP).Methods:A total of 92 patients with SAP from January 2014 to December 2017 in our hospital were enrolled in this study. According to random number table method, the patients were divided into the control group and the treatment group, each groups has 46 patients. The control group were treated with octreotide, the treatment group were treated with octreotide combined with gabexate. To compare the serum B7-H3, PCT, sICAM-1, NF-κB, sTREM-1, BAFF, SAA, NGAL, ghrelin, hs-CRP, MDA and SOD of the two groups before and after treatment.Results: The serum B7-H3, PCT, sICAM-1, NF-κB, sTREM-1, BAFF, SAA, NGAL, ghrelin, hs-CRP, MDA and SOD of the two groups before treatment have no no significantly differences. The serum B7-H3, PCT, sICAM-1, NF-κB, sTREM-1, BAFF, SAA, NGAL, ghrelin, hs-CRP, MDA of the two groups after treatment were significantly lower than before treatment, the serum SOD of the two groups after treatment were significantly better than before treatment, and that of the treatment group were significantly better than the control group after treatment.Conclusion: Octreotide combined with gabexate for patients with SAP can reduce the serum B7-H3, PCT, sICAM-1, NF-κB, sTREM-1, BAFF, SAA, NGAL, ghrelin, hs-CRP, MDA levels, improve serum SOD levels, and it was worthy clinical application.</abstract><pub>Emergency Medicine Department, First people's Hospital of Kunshan, Kunshan 215300 China</pub></addata></record>
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title Effects of octreotide combined with gabexate on related cytokines in patients with severe acute pancreatitis
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