Effect of vitamin C combined with vitamin E on antioxidant capacity and inflammatory response in patients with hemodialysis

Effect of vitamin C combined with vitamin E on antioxidant capacity and inflammatory response in patients with hemodialysis

Objective: To study the effect of vitamin C combined with vitamin E on antioxidant capacity and inflammatory response in patients with hemodialysis. Methods: A total of 116 patients with uremia who received hemodialysis in the hospital between December 2014 and January 2017 were collected and divide...

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Veröffentlicht in:海南医科大学学报（英文版） 2017, Vol.23 (19), p.39-42
Hauptverfasser: Yi-Ming Li, Ling Zhang, Xiao-Zhen Xing, Zhi-Fang Wang, Liang Zhu, Hai-Zhen Gu, Qing-Hong Lu, Jin-Xiao Jiang
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container_issue 19
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container_title 海南医科大学学报（英文版）
container_volume 23
creator Yi-Ming Li
Ling Zhang
Xiao-Zhen Xing
Zhi-Fang Wang
Liang Zhu
Hai-Zhen Gu
Qing-Hong Lu
Jin-Xiao Jiang
description Objective: To study the effect of vitamin C combined with vitamin E on antioxidant capacity and inflammatory response in patients with hemodialysis. Methods: A total of 116 patients with uremia who received hemodialysis in the hospital between December 2014 and January 2017 were collected and divided into control group and observation group by random number table, each with 58 cases. Control group received vitamin C intervention, and observation group received vitamin C combined with vitamin E intervention. The differences in serum levels of antioxidant indexes, pro-inflammatory mediators and anti-inflammatory mediators were compared between the two groups before intervention and 6 weeks after intervention. Results: Before intervention, serum levels of antioxidant indexes, pro-inflammatory mediators and anti-inflammatory mediators were not significantly different between the two groups. After intervention, serum SOD, GSH-PX and T-AOC levels of both groups of patients were higher than those before treatment while IL-1, IL-2, IL-6, IL-8, IL-4, IL-10 and IL-13 levels were lower than those before treatment, and serum SOD, GSH-PX and T-AOC levels of observation group were higher than those of control group while IL-1, IL-2, IL-6, IL-8, IL-4, IL-10 and IL-13 levels were lower than those of control group. Conclusion: Vitamin C combined with vitamin E intervention can effectively enhance the antioxidant capacity and suppress the systemic inflammatory state in patients with hemodialysis.
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Methods: A total of 116 patients with uremia who received hemodialysis in the hospital between December 2014 and January 2017 were collected and divided into control group and observation group by random number table, each with 58 cases. Control group received vitamin C intervention, and observation group received vitamin C combined with vitamin E intervention. The differences in serum levels of antioxidant indexes, pro-inflammatory mediators and anti-inflammatory mediators were compared between the two groups before intervention and 6 weeks after intervention. Results: Before intervention, serum levels of antioxidant indexes, pro-inflammatory mediators and anti-inflammatory mediators were not significantly different between the two groups. After intervention, serum SOD, GSH-PX and T-AOC levels of both groups of patients were higher than those before treatment while IL-1, IL-2, IL-6, IL-8, IL-4, IL-10 and IL-13 levels were lower than those before treatment, and serum SOD, GSH-PX and T-AOC levels of observation group were higher than those of control group while IL-1, IL-2, IL-6, IL-8, IL-4, IL-10 and IL-13 levels were lower than those of control group. Conclusion: Vitamin C combined with vitamin E intervention can effectively enhance the antioxidant capacity and suppress the systemic inflammatory state in patients with hemodialysis.</description><identifier>ISSN: 1007-1237</identifier><language>eng</language><publisher>Nephrology Department, Huanggang Central Hospital in Hubei Province, Huanggang City, Hubei Province, 438000</publisher><ispartof>海南医科大学学报（英文版）, 2017, Vol.23 (19), p.39-42</ispartof><rights>Copyright © Wanfang Data Co. Ltd. All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.wanfangdata.com.cn/images/PeriodicalImages/hnykdxxb-e/hnykdxxb-e.jpg</thumbnail><link.rule.ids>314,776,780,4010</link.rule.ids></links><search><creatorcontrib>Yi-Ming Li</creatorcontrib><creatorcontrib>Ling Zhang</creatorcontrib><creatorcontrib>Xiao-Zhen Xing</creatorcontrib><creatorcontrib>Zhi-Fang Wang</creatorcontrib><creatorcontrib>Liang Zhu</creatorcontrib><creatorcontrib>Hai-Zhen Gu</creatorcontrib><creatorcontrib>Qing-Hong Lu</creatorcontrib><creatorcontrib>Jin-Xiao Jiang</creatorcontrib><title>Effect of vitamin C combined with vitamin E on antioxidant capacity and inflammatory response in patients with hemodialysis</title><title>海南医科大学学报（英文版）</title><description>Objective: To study the effect of vitamin C combined with vitamin E on antioxidant capacity and inflammatory response in patients with hemodialysis. Methods: A total of 116 patients with uremia who received hemodialysis in the hospital between December 2014 and January 2017 were collected and divided into control group and observation group by random number table, each with 58 cases. Control group received vitamin C intervention, and observation group received vitamin C combined with vitamin E intervention. The differences in serum levels of antioxidant indexes, pro-inflammatory mediators and anti-inflammatory mediators were compared between the two groups before intervention and 6 weeks after intervention. Results: Before intervention, serum levels of antioxidant indexes, pro-inflammatory mediators and anti-inflammatory mediators were not significantly different between the two groups. After intervention, serum SOD, GSH-PX and T-AOC levels of both groups of patients were higher than those before treatment while IL-1, IL-2, IL-6, IL-8, IL-4, IL-10 and IL-13 levels were lower than those before treatment, and serum SOD, GSH-PX and T-AOC levels of observation group were higher than those of control group while IL-1, IL-2, IL-6, IL-8, IL-4, IL-10 and IL-13 levels were lower than those of control group. 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After intervention, serum SOD, GSH-PX and T-AOC levels of both groups of patients were higher than those before treatment while IL-1, IL-2, IL-6, IL-8, IL-4, IL-10 and IL-13 levels were lower than those before treatment, and serum SOD, GSH-PX and T-AOC levels of observation group were higher than those of control group while IL-1, IL-2, IL-6, IL-8, IL-4, IL-10 and IL-13 levels were lower than those of control group. Conclusion: Vitamin C combined with vitamin E intervention can effectively enhance the antioxidant capacity and suppress the systemic inflammatory state in patients with hemodialysis.</abstract><pub>Nephrology Department, Huanggang Central Hospital in Hubei Province, Huanggang City, Hubei Province, 438000</pub></addata></record>
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title Effect of vitamin C combined with vitamin E on antioxidant capacity and inflammatory response in patients with hemodialysis
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