LncRNA及其作为ceRNA参与卵巢功能和相关疾病的研究进展

LncRNA及其作为ceRNA参与卵巢功能和相关疾病的研究进展

长链非编码RNA(long non-coding RNA,lncRNA)可通过转录、转录后调控及表观遗传修饰等影响基因的表达,参与调控卵巢生理功能.LncRNA还可作为竞争性内源RNA(competing endogenous RNA,ceRNA),通过竞争性结合微RNA(micro RNA,miRNA)而影响靶基因mRNA的表达,该调控方式称为lncRNA/miRNA/mRNA调控网络.LncRNA/miRNA/mRNA网络在调控卵巢生理功能和卵巢生殖功能障碍性疾病的发生、发展中起重要作用,有望成为治疗生殖障碍性疾病的新靶点和诊断指标....

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Veröffentlicht in:中南大学学报（医学版） 2021, Vol.46 (7), p.745-752
Hauptverfasser: 李玉玲, 陈婕, 罗倩倩, 谈勇
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container_end_page 752
container_issue 7
container_start_page 745
container_title 中南大学学报（医学版）
container_volume 46
creator 李玉玲
陈婕
罗倩倩
谈勇
description 长链非编码RNA(long non-coding RNA,lncRNA)可通过转录、转录后调控及表观遗传修饰等影响基因的表达,参与调控卵巢生理功能.LncRNA还可作为竞争性内源RNA(competing endogenous RNA,ceRNA),通过竞争性结合微RNA(micro RNA,miRNA)而影响靶基因mRNA的表达,该调控方式称为lncRNA/miRNA/mRNA调控网络.LncRNA/miRNA/mRNA网络在调控卵巢生理功能和卵巢生殖功能障碍性疾病的发生、发展中起重要作用,有望成为治疗生殖障碍性疾病的新靶点和诊断指标.
doi_str_mv 10.11817/j.issn.1672-7347.2021.200622
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title LncRNA及其作为ceRNA参与卵巢功能和相关疾病的研究进展
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