Regulation of ciliary trafficking of polycystin-2 and the pathogenesis of autosomal dominant polycystic kidney disease
Autosomal dominant human hereditary disorder characteristi polycystic kidney disease （ADPKD） is one of the most common c of develop cumulated evidence has suggested that primary cili ment of bilateral multiple fluid-filled kidney cysts. Acum of renal epithelial cell plays a key role in cystogenesis....
Gespeichert in:
| Veröffentlicht in: | Zhong nan da xue xue bao. Journal of Central South University. Yi xue ban 2010-02, Vol.35 (2), p.93-99 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | chi ; eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 99 |
|---|---|
| container_issue | 2 |
| container_start_page | 93 |
| container_title | Zhong nan da xue xue bao. Journal of Central South University. Yi xue ban |
| container_volume | 35 |
| creator | Cai, Yiqiang Tang, Zhangui |
| description | Autosomal dominant human hereditary disorder characteristi polycystic kidney disease （ADPKD） is one of the most common c of develop cumulated evidence has suggested that primary cili ment of bilateral multiple fluid-filled kidney cysts. Acum of renal epithelial cell plays a key role in cystogenesis. In this article we will give an overview on the basic information about polycystic kidney disease （PKD） and summarize the recent progresses in studies of regulation of polycystin-1 and -2 trafficking to cilia. We will also discuss the possible role of trafficking defects of polycystins on the pathogenesis of ADPKD. |
| doi_str_mv | 10.3969/j.issn.1672-7347.2010.02.001 |
| format | Article |
| fullrecord | <record><control><sourceid>wanfang_jour_proqu</sourceid><recordid>TN_cdi_wanfang_journals_hnykdx201002001</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><cqvip_id>33197023</cqvip_id><wanfj_id>hnykdx201002001</wanfj_id><sourcerecordid>hnykdx201002001</sourcerecordid><originalsourceid>FETCH-LOGICAL-c1841-fd5dfdeb0de48899d4e325a191e2068975362c4fc02348ac8b2e1634a7af2f4c3</originalsourceid><addsrcrecordid>eNpFkE1LxDAQhnNQVNb9CxJE8NSaJt22OYr4BYIgei7TZNKN2yZr06r992bx6zQw88y8w0PIWcZSIQt58ZraEFyaFSVPSpGXKWdxxHjKWLZHjv76h2QZgm0Yk1KKoioPyGEkZVmw1RF5f8J26mC03lFvqLKdhWGm4wDGWLWxrt21t76b1RxG6xJOwWk6rpFuYVz7Fh0GG3YQTKMPvoeOat9bB27831N0Y7XDmWobEAIek30DXcDlT12Ql5vr56u75OHx9v7q8iFRWZVnidErbTQ2TGNeVVLqHAVfQSYz5KyoZLkSBVe5UYyLvAJVNRyzQuRQguEmV2JBzr_vfoAz4Nr61U-Di4n12s0b_blTxngU9k9uB_82YRjr3gaFXQcO_RTqUsQoXsXEBTn5IaemR11vB9tHZ_Wv1AicfgNq7V37Fh3WDaiNsR3WQkQofiu-AMLOiIw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>733622875</pqid></control><display><type>article</type><title>Regulation of ciliary trafficking of polycystin-2 and the pathogenesis of autosomal dominant polycystic kidney disease</title><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>Cai, Yiqiang ; Tang, Zhangui</creator><creatorcontrib>Cai, Yiqiang ; Tang, Zhangui</creatorcontrib><description>Autosomal dominant human hereditary disorder characteristi polycystic kidney disease （ADPKD） is one of the most common c of develop cumulated evidence has suggested that primary cili ment of bilateral multiple fluid-filled kidney cysts. Acum of renal epithelial cell plays a key role in cystogenesis. In this article we will give an overview on the basic information about polycystic kidney disease （PKD） and summarize the recent progresses in studies of regulation of polycystin-1 and -2 trafficking to cilia. We will also discuss the possible role of trafficking defects of polycystins on the pathogenesis of ADPKD.</description><identifier>ISSN: 1672-7347</identifier><identifier>DOI: 10.3969/j.issn.1672-7347.2010.02.001</identifier><identifier>PMID: 20197605</identifier><language>chi ; eng</language><publisher>China: Department of Internal Medicine, Yale University School of Medicine, New Haven CT 06510, USA%Department of Oral & Maxillofacial Surgery, Stomatological School, Central South University, Changsha 410078, China</publisher><subject>Animals ; Cilia - metabolism ; Epithelial Cells - metabolism ; Humans ; Kidney - metabolism ; Kidney - pathology ; Polycystic Kidney, Autosomal Dominant - etiology ; Polycystic Kidney, Autosomal Dominant - genetics ; Polycystic Kidney, Autosomal Dominant - metabolism ; Protein Transport ; Receptors, Cell Surface - genetics ; Receptors, Cell Surface - metabolism ; Receptors, Cell Surface - physiology ; TRPP Cation Channels - genetics ; TRPP Cation Channels - metabolism ; TRPP Cation Channels - physiology ; 临床分析 ; 多囊肾 ; 患者 ; 肾衰竭</subject><ispartof>Zhong nan da xue xue bao. Journal of Central South University. Yi xue ban, 2010-02, Vol.35 (2), p.93-99</ispartof><rights>Copyright © Wanfang Data Co. Ltd. All Rights Reserved.</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/90655A/90655A.jpg</thumbnail><link.rule.ids>315,781,785,27928,27929</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20197605$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cai, Yiqiang</creatorcontrib><creatorcontrib>Tang, Zhangui</creatorcontrib><title>Regulation of ciliary trafficking of polycystin-2 and the pathogenesis of autosomal dominant polycystic kidney disease</title><title>Zhong nan da xue xue bao. Journal of Central South University. Yi xue ban</title><addtitle>Journal of Central South University （Medical Sciences） Journal of Central South University （Medical Sciences）</addtitle><description>Autosomal dominant human hereditary disorder characteristi polycystic kidney disease （ADPKD） is one of the most common c of develop cumulated evidence has suggested that primary cili ment of bilateral multiple fluid-filled kidney cysts. Acum of renal epithelial cell plays a key role in cystogenesis. In this article we will give an overview on the basic information about polycystic kidney disease （PKD） and summarize the recent progresses in studies of regulation of polycystin-1 and -2 trafficking to cilia. We will also discuss the possible role of trafficking defects of polycystins on the pathogenesis of ADPKD.</description><subject>Animals</subject><subject>Cilia - metabolism</subject><subject>Epithelial Cells - metabolism</subject><subject>Humans</subject><subject>Kidney - metabolism</subject><subject>Kidney - pathology</subject><subject>Polycystic Kidney, Autosomal Dominant - etiology</subject><subject>Polycystic Kidney, Autosomal Dominant - genetics</subject><subject>Polycystic Kidney, Autosomal Dominant - metabolism</subject><subject>Protein Transport</subject><subject>Receptors, Cell Surface - genetics</subject><subject>Receptors, Cell Surface - metabolism</subject><subject>Receptors, Cell Surface - physiology</subject><subject>TRPP Cation Channels - genetics</subject><subject>TRPP Cation Channels - metabolism</subject><subject>TRPP Cation Channels - physiology</subject><subject>临床分析</subject><subject>多囊肾</subject><subject>患者</subject><subject>肾衰竭</subject><issn>1672-7347</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkE1LxDAQhnNQVNb9CxJE8NSaJt22OYr4BYIgei7TZNKN2yZr06r992bx6zQw88y8w0PIWcZSIQt58ZraEFyaFSVPSpGXKWdxxHjKWLZHjv76h2QZgm0Yk1KKoioPyGEkZVmw1RF5f8J26mC03lFvqLKdhWGm4wDGWLWxrt21t76b1RxG6xJOwWk6rpFuYVz7Fh0GG3YQTKMPvoeOat9bB27831N0Y7XDmWobEAIek30DXcDlT12Ql5vr56u75OHx9v7q8iFRWZVnidErbTQ2TGNeVVLqHAVfQSYz5KyoZLkSBVe5UYyLvAJVNRyzQuRQguEmV2JBzr_vfoAz4Nr61U-Di4n12s0b_blTxngU9k9uB_82YRjr3gaFXQcO_RTqUsQoXsXEBTn5IaemR11vB9tHZ_Wv1AicfgNq7V37Fh3WDaiNsR3WQkQofiu-AMLOiIw</recordid><startdate>201002</startdate><enddate>201002</enddate><creator>Cai, Yiqiang</creator><creator>Tang, Zhangui</creator><general>Department of Internal Medicine, Yale University School of Medicine, New Haven CT 06510, USA%Department of Oral & Maxillofacial Surgery, Stomatological School, Central South University, Changsha 410078, China</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>W91</scope><scope>~WA</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope><scope>2B.</scope><scope>4A8</scope><scope>92I</scope><scope>93N</scope><scope>PSX</scope><scope>TCJ</scope></search><sort><creationdate>201002</creationdate><title>Regulation of ciliary trafficking of polycystin-2 and the pathogenesis of autosomal dominant polycystic kidney disease</title><author>Cai, Yiqiang ; Tang, Zhangui</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1841-fd5dfdeb0de48899d4e325a191e2068975362c4fc02348ac8b2e1634a7af2f4c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>chi ; eng</language><creationdate>2010</creationdate><topic>Animals</topic><topic>Cilia - metabolism</topic><topic>Epithelial Cells - metabolism</topic><topic>Humans</topic><topic>Kidney - metabolism</topic><topic>Kidney - pathology</topic><topic>Polycystic Kidney, Autosomal Dominant - etiology</topic><topic>Polycystic Kidney, Autosomal Dominant - genetics</topic><topic>Polycystic Kidney, Autosomal Dominant - metabolism</topic><topic>Protein Transport</topic><topic>Receptors, Cell Surface - genetics</topic><topic>Receptors, Cell Surface - metabolism</topic><topic>Receptors, Cell Surface - physiology</topic><topic>TRPP Cation Channels - genetics</topic><topic>TRPP Cation Channels - metabolism</topic><topic>TRPP Cation Channels - physiology</topic><topic>临床分析</topic><topic>多囊肾</topic><topic>患者</topic><topic>肾衰竭</topic><toplevel>online_resources</toplevel><creatorcontrib>Cai, Yiqiang</creatorcontrib><creatorcontrib>Tang, Zhangui</creatorcontrib><collection>中文科技期刊数据库</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>中文科技期刊数据库-7.0平台</collection><collection>中文科技期刊数据库-医药卫生</collection><collection>中文科技期刊数据库- 镜像站点</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>Wanfang Data Journals - Hong Kong</collection><collection>WANFANG Data Centre</collection><collection>Wanfang Data Journals</collection><collection>万方数据期刊 - 香港版</collection><collection>China Online Journals (COJ)</collection><collection>China Online Journals (COJ)</collection><jtitle>Zhong nan da xue xue bao. Journal of Central South University. Yi xue ban</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cai, Yiqiang</au><au>Tang, Zhangui</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Regulation of ciliary trafficking of polycystin-2 and the pathogenesis of autosomal dominant polycystic kidney disease</atitle><jtitle>Zhong nan da xue xue bao. Journal of Central South University. Yi xue ban</jtitle><addtitle>Journal of Central South University （Medical Sciences） Journal of Central South University （Medical Sciences）</addtitle><date>2010-02</date><risdate>2010</risdate><volume>35</volume><issue>2</issue><spage>93</spage><epage>99</epage><pages>93-99</pages><issn>1672-7347</issn><abstract>Autosomal dominant human hereditary disorder characteristi polycystic kidney disease （ADPKD） is one of the most common c of develop cumulated evidence has suggested that primary cili ment of bilateral multiple fluid-filled kidney cysts. Acum of renal epithelial cell plays a key role in cystogenesis. In this article we will give an overview on the basic information about polycystic kidney disease （PKD） and summarize the recent progresses in studies of regulation of polycystin-1 and -2 trafficking to cilia. We will also discuss the possible role of trafficking defects of polycystins on the pathogenesis of ADPKD.</abstract><cop>China</cop><pub>Department of Internal Medicine, Yale University School of Medicine, New Haven CT 06510, USA%Department of Oral & Maxillofacial Surgery, Stomatological School, Central South University, Changsha 410078, China</pub><pmid>20197605</pmid><doi>10.3969/j.issn.1672-7347.2010.02.001</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1672-7347 |
| ispartof | Zhong nan da xue xue bao. Journal of Central South University. Yi xue ban, 2010-02, Vol.35 (2), p.93-99 |
| issn | 1672-7347 |
| language | chi ; eng |
| recordid | cdi_wanfang_journals_hnykdx201002001 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Animals Cilia - metabolism Epithelial Cells - metabolism Humans Kidney - metabolism Kidney - pathology Polycystic Kidney, Autosomal Dominant - etiology Polycystic Kidney, Autosomal Dominant - genetics Polycystic Kidney, Autosomal Dominant - metabolism Protein Transport Receptors, Cell Surface - genetics Receptors, Cell Surface - metabolism Receptors, Cell Surface - physiology TRPP Cation Channels - genetics TRPP Cation Channels - metabolism TRPP Cation Channels - physiology 临床分析 多囊肾 患者 肾衰竭 |
| title | Regulation of ciliary trafficking of polycystin-2 and the pathogenesis of autosomal dominant polycystic kidney disease |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-16T14%3A02%3A40IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-wanfang_jour_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Regulation%20of%20ciliary%20trafficking%20of%20polycystin-2%20and%20the%20pathogenesis%20of%20autosomal%20dominant%20polycystic%20kidney%20disease&rft.jtitle=Zhong%20nan%20da%20xue%20xue%20bao.%20Journal%20of%20Central%20South%20University.%20Yi%20xue%20ban&rft.au=Cai,%20Yiqiang&rft.date=2010-02&rft.volume=35&rft.issue=2&rft.spage=93&rft.epage=99&rft.pages=93-99&rft.issn=1672-7347&rft_id=info:doi/10.3969/j.issn.1672-7347.2010.02.001&rft_dat=%3Cwanfang_jour_proqu%3Ehnykdx201002001%3C/wanfang_jour_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=733622875&rft_id=info:pmid/20197605&rft_cqvip_id=33197023&rft_wanfj_id=hnykdx201002001&rfr_iscdi=true |