环孢素和舒莱单一或联合应用对大鼠同种异体心脏移植抗排斥的作用

目的：观察环孢素A和舒莱单一或联合用药对大鼠同种异体心脏移植的作用，评价联合用药的药效。方法：不同剂量环孢素A和舒莱单一或联合用于大鼠心脏移植，术后观察移植心存活时间，取移植心行病理组织学检查，检测血清IL-2和IL-4水平．结果：单一及联合用药均能延长移植心的存活时间，而且移植心存活时间越长．其发生排斥反应的程度就越轻，在急性排斥时血清IL-2水平明显升高，而移植心长期存活者IL-4水平明显升高。结论：环孢素A和舒莱可有效地抑制同种异体的移植排斥反应，联合应用有明显的协同作用。...

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Veröffentlicht in:	Zhong nan da xue xue bao. Journal of Central South University. Yi xue ban 2005, Vol.30 (5), p.549-552
1. Verfasser:	熊海波夏穗生黄祖发叶启发温浩
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Sprache:	chi
Schlagworte:	免疫耐受协同作用大鼠心脏移植排斥反应环孢素A 舒莱
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container_title	Zhong nan da xue xue bao. Journal of Central South University. Yi xue ban
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creator	熊海波夏穗生黄祖发叶启发温浩
description	目的：观察环孢素A和舒莱单一或联合用药对大鼠同种异体心脏移植的作用，评价联合用药的药效。方法：不同剂量环孢素A和舒莱单一或联合用于大鼠心脏移植，术后观察移植心存活时间，取移植心行病理组织学检查，检测血清IL-2和IL-4水平．结果：单一及联合用药均能延长移植心的存活时间，而且移植心存活时间越长．其发生排斥反应的程度就越轻，在急性排斥时血清IL-2水平明显升高，而移植心长期存活者IL-4水平明显升高。结论：环孢素A和舒莱可有效地抑制同种异体的移植排斥反应，联合应用有明显的协同作用。
doi_str_mv	10.3321/j.issn:1672-7347.2005.05.012
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Yi xue ban</title><addtitle>Journal of Central South University (Medical Sciences) Journal of Central South University (Medical Sciences)</addtitle><description>目的：观察环孢素A和舒莱单一或联合用药对大鼠同种异体心脏移植的作用，评价联合用药的药效。方法：不同剂量环孢素A和舒莱单一或联合用于大鼠心脏移植，术后观察移植心存活时间，取移植心行病理组织学检查，检测血清IL-2和IL-4水平．结果：单一及联合用药均能延长移植心的存活时间，而且移植心存活时间越长．其发生排斥反应的程度就越轻，在急性排斥时血清IL-2水平明显升高，而移植心长期存活者IL-4水平明显升高。结论：环孢素A和舒莱可有效地抑制同种异体的移植排斥反应，联合应用有明显的协同作用。</description><subject>免疫耐受</subject><subject>协同作用</subject><subject>大鼠</subject><subject>心脏移植</subject><subject>排斥反应</subject><subject>环孢素A</subject><subject>舒莱</subject><issn>1672-7347</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><recordid>eNpjYFAxNNAzNjYy1M_SyywuzrMyNDM30jU3NjHXMzIwMNUDIUMjFgZOuDgHA29xcWaSgYGlpaWxmYU5J0PU8771T9cuer5lwdNJPS86Jr3o2_i0d-qTHQ3POqa9aJzydELH011Tnk9Z8XT9zqdLlr_cs-DphJ7ny3uf7ml6snfy0_3NL1r6ny_f_WxJ77Ou6c_6Jj2btvT5rJYne-cAtfAwsKYl5hSn8kJpboYQN9cQZw9dH393T2dHH91kU0sjXRMDY1OTNFPTFBML4yRLoIhRskVaqqF5cmpikmWyuVGiSaKxobEFkE5LTjMyNk9JTk4xNQKSyYZmyUlpKcbcDOoQY8sT89IS89Ljs_JLi_KAFsZn5FVmp1SAggIIDY2AKpUgKpMz8vPSCzOBapMSk7PTMnNS440MgAFpYGJiDACVsIJ9</recordid><startdate>2005</startdate><enddate>2005</enddate><creator>熊海波夏穗生黄祖发叶启发温浩</creator><general>中南大学湘雅三医院器官移植研究院,长沙,410013%华中科技大学同济医学院器官移植研究所,武汉,430030%新疆医科大学第一附属医院普外科,乌鲁木齐,830054</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>W91</scope><scope>~WA</scope><scope>2B.</scope><scope>4A8</scope><scope>92I</scope><scope>93N</scope><scope>PSX</scope><scope>TCJ</scope></search><sort><creationdate>2005</creationdate><title>环孢素和舒莱单一或联合应用对大鼠同种异体心脏移植抗排斥的作用</title><author>熊海波夏穗生黄祖发叶启发温浩</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c592-40354f55d483b95922c8fe17ceab9c72a4a31382a4fcf237dccd52dccc16cbfd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>chi</language><creationdate>2005</creationdate><topic>免疫耐受</topic><topic>协同作用</topic><topic>大鼠</topic><topic>心脏移植</topic><topic>排斥反应</topic><topic>环孢素A</topic><topic>舒莱</topic><toplevel>online_resources</toplevel><creatorcontrib>熊海波夏穗生黄祖发叶启发温浩</creatorcontrib><collection>维普_期刊</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>维普中文期刊数据库</collection><collection>中文科技期刊数据库-医药卫生</collection><collection>中文科技期刊数据库- 镜像站点</collection><collection>Wanfang Data Journals - Hong Kong</collection><collection>WANFANG Data Centre</collection><collection>Wanfang Data Journals</collection><collection>万方数据期刊 - 香港版</collection><collection>China Online Journals (COJ)</collection><collection>China Online Journals (COJ)</collection><jtitle>Zhong nan da xue xue bao. Journal of Central South University. Yi xue ban</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>熊海波夏穗生黄祖发叶启发温浩</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>环孢素和舒莱单一或联合应用对大鼠同种异体心脏移植抗排斥的作用</atitle><jtitle>Zhong nan da xue xue bao. Journal of Central South University. Yi xue ban</jtitle><addtitle>Journal of Central South University (Medical Sciences) Journal of Central South University (Medical Sciences)</addtitle><date>2005</date><risdate>2005</risdate><volume>30</volume><issue>5</issue><spage>549</spage><epage>552</epage><pages>549-552</pages><issn>1672-7347</issn><abstract>目的：观察环孢素A和舒莱单一或联合用药对大鼠同种异体心脏移植的作用，评价联合用药的药效。方法：不同剂量环孢素A和舒莱单一或联合用于大鼠心脏移植，术后观察移植心存活时间，取移植心行病理组织学检查，检测血清IL-2和IL-4水平．结果：单一及联合用药均能延长移植心的存活时间，而且移植心存活时间越长．其发生排斥反应的程度就越轻，在急性排斥时血清IL-2水平明显升高，而移植心长期存活者IL-4水平明显升高。结论：环孢素A和舒莱可有效地抑制同种异体的移植排斥反应，联合应用有明显的协同作用。</abstract><pub>中南大学湘雅三医院器官移植研究院,长沙,410013%华中科技大学同济医学院器官移植研究所,武汉,430030%新疆医科大学第一附属医院普外科,乌鲁木齐,830054</pub><doi>10.3321/j.issn:1672-7347.2005.05.012</doi><tpages>4</tpages></addata></record>
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subjects	免疫耐受协同作用大鼠心脏移植排斥反应环孢素A 舒莱
title	环孢素和舒莱单一或联合应用对大鼠同种异体心脏移植抗排斥的作用
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