泛素-蛋白酶体通路

泛素-蛋白酶体通路

泛素-蛋白酶体通路介导的细胞蛋白降解是一个复杂、缜密的调控过程，同时在细胞周期、基因转录及表达、抗原提呈和炎症演进等方面发挥调控作用，尤其是通过降解细胞各通路的抑制因子或／和激活因子发挥上调或下调作用；而且泛素-蛋白酶体通路的异常与诸多疾病如恶性肿瘤、神经变性疾病、遗传性疾病、炎症、心肌病的致病机制有关。对于细胞应用该通路降解靶蛋白机制的阐明，将有助于研发这些疾患的治疗方法。...

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Veröffentlicht in:Zhong nan da xue xue bao. Journal of Central South University. Yi xue ban 2004, Vol.29 (2), p.230-232
1. Verfasser: 肖炳燚 李桂源
Format: Artikel
Sprache:chi
Schlagworte:
基因转录
泛素-蛋白酶体通路
炎症
细胞周期
细胞蛋白降解
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container_title Zhong nan da xue xue bao. Journal of Central South University. Yi xue ban
container_volume 29
creator 肖炳燚 李桂源
description 泛素-蛋白酶体通路介导的细胞蛋白降解是一个复杂、缜密的调控过程，同时在细胞周期、基因转录及表达、抗原提呈和炎症演进等方面发挥调控作用，尤其是通过降解细胞各通路的抑制因子或／和激活因子发挥上调或下调作用；而且泛素-蛋白酶体通路的异常与诸多疾病如恶性肿瘤、神经变性疾病、遗传性疾病、炎症、心肌病的致病机制有关。对于细胞应用该通路降解靶蛋白机制的阐明，将有助于研发这些疾患的治疗方法。
doi_str_mv 10.3321/j.issn:1672-7347.2004.02.032
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subjects 基因转录
泛素-蛋白酶体通路
炎症
细胞周期
细胞蛋白降解
title 泛素-蛋白酶体通路
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