Aβ显像剂99Tcm-MAMA-DMABP的合成及生物分布
O6; 制备了新的Aβ斑块显像剂99Tcm-酰胺基氨基二硫醇(MAMA)-4-氨基-4′-二甲氨基联苯(DMABP),并研究了其在正常小鼠体内的生物分布.实验结果表明,99Tcm-MAMA-DMABP具有较高的初始脑摄取,较快的正常脑组织清除,尾静脉注射后2 min的脑摄取达0.88%/g,2 min与60 min的脑摄取率比值为2.8....
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| Veröffentlicht in: | 核化学与放射化学 2006, Vol.28 (3), p.157-162 |
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| container_title | 核化学与放射化学 |
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| creator | 王武尚 陈祥纪 刘伯里 |
| description | O6; 制备了新的Aβ斑块显像剂99Tcm-酰胺基氨基二硫醇(MAMA)-4-氨基-4′-二甲氨基联苯(DMABP),并研究了其在正常小鼠体内的生物分布.实验结果表明,99Tcm-MAMA-DMABP具有较高的初始脑摄取,较快的正常脑组织清除,尾静脉注射后2 min的脑摄取达0.88%/g,2 min与60 min的脑摄取率比值为2.8. |
| doi_str_mv | 10.3969/j.issn.0253-9950.2006.03.005 |
| format | Article |
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| title | Aβ显像剂99Tcm-MAMA-DMABP的合成及生物分布 |
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