可溶性B7-H4在类风湿性关节炎中的诊断价值探讨
目的探讨可溶性B7-H4(sB7-H4)在类风湿性关节炎(RA)中的诊断价值。方法应用酶联免疫吸附试验(ELISA)检测67例RA患者,72例骨性关节炎(OA)与75例健康人血清sB7-H4、抗环瓜氨酸肽(CCP)抗体、葡萄糖6-磷酸异构酶(GPI)水平,免疫比浊法测定类风湿因子(RF)。比较分析sB7-H4在RA诊断中的应用价值。结果 RA患者血清sB7-H4水平明显高于对照组和OA组,差异有统计学意义(P<0.01);sB7-H4在RA诊断中的灵敏度高于RF、抗CCP抗体、GPI,特异性低于抗CCP抗体及GPI;sB7-H4与RF、抗CCP抗体有良好的相关性;联合检测sB7-...
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| Veröffentlicht in: | 国际检验医学杂志 2014 (15), p.1997-1999 |
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| container_title | 国际检验医学杂志 |
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| creator | 莫莉 姜健 姚炯涛 谭兴权 |
| description | 目的探讨可溶性B7-H4(sB7-H4)在类风湿性关节炎(RA)中的诊断价值。方法应用酶联免疫吸附试验(ELISA)检测67例RA患者,72例骨性关节炎(OA)与75例健康人血清sB7-H4、抗环瓜氨酸肽(CCP)抗体、葡萄糖6-磷酸异构酶(GPI)水平,免疫比浊法测定类风湿因子(RF)。比较分析sB7-H4在RA诊断中的应用价值。结果 RA患者血清sB7-H4水平明显高于对照组和OA组,差异有统计学意义(P<0.01);sB7-H4在RA诊断中的灵敏度高于RF、抗CCP抗体、GPI,特异性低于抗CCP抗体及GPI;sB7-H4与RF、抗CCP抗体有良好的相关性;联合检测sB7-H4、RF、抗CCP抗体、GPI可提高RA的诊断率。结论sB7-H4在RA诊断中具有良好的临床应用前景。 |
| doi_str_mv | 10.3969/j.issn.1673-4130.2014.15.013 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 1673-4130 |
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| language | chi |
| recordid | cdi_wanfang_journals_gwyx_lcsw201415013 |
| source | Alma/SFX Local Collection |
| subjects | 类风湿因子 类风湿性关节炎 酶联免疫吸附测定 |
| title | 可溶性B7-H4在类风湿性关节炎中的诊断价值探讨 |
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