Advances in Translational Medicine of Liver Regeneration-Associated Regulatory Factors

The liver is an important organ that has strong regeneration and defensive ability in human body. The cell types participating in liver regeneration have close association with the severity of liver injury. When the liver is in mild injury, it mainly repairs the injury through the cellular proliferation of liver parenchyma, whereas when the liver is in severe injury complicated with liver cell aplasia, the liver tissues will launch stem cell proliferative responses. Liver cells and stem cells have different responses to injury, so there may be specific regulation of signal routines and factors. Translational medicine mainly guides clinical practice through basic research, which not only promotes the development of modern medicine, but also is the strong impetus that promotes the development of modern medicine. The application of translational medicine has greatly improved the therapeutic efifcacy of liver surgery, liver cancer and liver transplantation around the world. This study mainly reviewed the advances in translational medicine of liver regeneration-associated regulatory factors, hoping to provide references for the clinical diagnosis and treatment of liver diseases.