Involvement of the circular RNA/microRNA/glucose-6-phosphate dehydrogenase axis in the pathological mechanism of hepatocellular carcinoma

Involvement of the circular RNA/microRNA/glucose-6-phosphate dehydrogenase axis in the pathological mechanism of hepatocellular carcinoma

Hepatocellular carcinoma (HCC) is the third most common cause of cancer-related death worldwide with high mortality. The incidence of HCC is increasing in China. Abnormal activation of glucose-6-phosphate dehydrogenase (G6PD) exists in all malignant tumors, including HCC, and is closely related to t...

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Veröffentlicht in:Hepatobiliary & pancreatic diseases international 2021-12, Vol.20 (6), p.530-534
Hauptverfasser: Wang, Ying, Zhou, Xin-Yi, Lu, Xiang-Yun, Chen, Ke-Da, Yao, Hang-Ping
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Glucose-6-phosphate dehydrogenase
Hepatocellular carcinoma
Non-coding RNA
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container_end_page 534
container_issue 6
container_start_page 530
container_title Hepatobiliary & pancreatic diseases international
container_volume 20
creator Wang, Ying
Zhou, Xin-Yi
Lu, Xiang-Yun
Chen, Ke-Da
Yao, Hang-Ping
description Hepatocellular carcinoma (HCC) is the third most common cause of cancer-related death worldwide with high mortality. The incidence of HCC is increasing in China. Abnormal activation of glucose-6-phosphate dehydrogenase (G6PD) exists in all malignant tumors, including HCC, and is closely related to the development of HCC. In addition, the differential expression of non-coding RNAs is closely related to the development of HCC. This systematic review focuses on the relationship between G6PD, HCC, and non-coding RNA, which form the basis for the circRNA/miRNA/G6PD axis in HCC. The circular RNA (circRNA)/microRNA (miRNA)/G6PD axis is involved in development of HCC. We proposed that non-coding RNA molecules of the circRNA/miRNA/G6PD axis may be novel biomarkers for the pathological diagnosis, prognosis, and targeted therapy of HCC.
doi_str_mv 10.1016/j.hbpd.2021.08.013
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subjects Glucose-6-phosphate dehydrogenase
Hepatocellular carcinoma
Non-coding RNA
title Involvement of the circular RNA/microRNA/glucose-6-phosphate dehydrogenase axis in the pathological mechanism of hepatocellular carcinoma
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