Incomplete radiofrequency ablation promotes the development of CD133+ cancer stem cells in hepatocellular carcinoma cell line HepG2 via inducing SOX9 expression

Cancer stem cells (CSCs) accelerate the growth of hepatocellular carcinoma (HCC) residual after incomplete radiofrequency ablation (In-RFA). The present study aimed to detect the effects of In-RFA on stemness transcription factors (STFs) expression which are important for the production and function...

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Veröffentlicht in:	Hepatobiliary & pancreatic diseases international 2018-10, Vol.17 (5), p.416-422
Hauptverfasser:	Yuan, Chun-Wang, Wang, Zhen-Chang, Liu, Kai, Liu, Dong-Jie
Format:	Artikel
Sprache:	eng
Schlagworte:	AC133 Antigen - genetics Animals Cancer stem cells Carcinogenesis - genetics Carcinoma, Hepatocellular - pathology Carcinoma, Hepatocellular - surgery Cell Line, Tumor Cell Proliferation Cell Survival - genetics Enzyme-Linked Immunosorbent Assay Flow Cytometry - methods Gene Expression Regulation, Neoplastic - genetics Hep G2 Cells Hepatocellular carcinoma HepG2 Humans Immunoblotting - methods In Vitro Techniques Liver Neoplasms - pathology Liver Neoplasms - surgery Mice Mice, Knockout Neoplastic Stem Cells Polymerase Chain Reaction - methods Radiofrequency ablation Radiofrequency Ablation - methods RNA, Messenger - analysis Sensitivity and Specificity Signal Transduction SOX9 Transcription Factor - genetics Up-Regulation
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