Emodin alleviates intestinal mucosal injury in rats with severe acute pancreatitis via the caspase-1 inhibition
Severe acute pancreatitis (SAP) is a potentially lethal disease characterized by sudden onset, rapid progression,multiple organ failure and high mortality rate.[1-3] The underlying pathogenesis remains incompletely elucidated. As main anatomic and functional barrier, gut mucosa impairment is conside...
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| Veröffentlicht in: | Hepatobiliary & pancreatic diseases international 2017-08, Vol.16 (4), p.431-436 |
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| description | Severe acute pancreatitis (SAP) is a potentially lethal disease characterized by sudden onset, rapid progression,multiple organ failure and high mortality rate.[1-3] The underlying pathogenesis remains incompletely elucidated. As main anatomic and functional barrier, gut mucosa impairment is considered one of the major pathologies in SAP,[4, 5] which will increase intestinal permeability, bacteria translocation as well as release of endotoxin, inflammatory mediators and cytokines(IL-1β, IL-18).[6]Caspase-1 (IL-1β-converting enzyme/ICE) is a common intracellular cysteine protease that converts the precursors of IL-1β and IL-18 into active cytokines.[7, 8]Blockade of caspase-1 suppresses inflammatory mediator expressions, such as IL-1β and IL-18, which will alleviate inflammation cascade reaction and ameliorate the overall severity and mortality of patients with SAP.[9, 10] |
| doi_str_mv | 10.1016/S1499-3872(17)60041-9 |
| format | Article |
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As main anatomic and functional barrier, gut mucosa impairment is considered one of the major pathologies in SAP,[4, 5] which will increase intestinal permeability, bacteria translocation as well as release of endotoxin, inflammatory mediators and cytokines(IL-1β, IL-18).[6]Caspase-1 (IL-1β-converting enzyme/ICE) is a common intracellular cysteine protease that converts the precursors of IL-1β and IL-18 into active cytokines.[7, 8]Blockade of caspase-1 suppresses inflammatory mediator expressions, such as IL-1β and IL-18, which will alleviate inflammation cascade reaction and ameliorate the overall severity and mortality of patients with SAP.[9, 10]</description><identifier>ISSN: 1499-3872</identifier><identifier>DOI: 10.1016/S1499-3872(17)60041-9</identifier><identifier>PMID: 28823375</identifier><language>eng</language><publisher>Singapore: Elsevier B.V</publisher><subject>acute ; Acute Disease ; Animals ; Caspase 1 - genetics ; Caspase 1 - metabolism ; Caspase Inhibitors - pharmacology ; caspase-1 inhibitor ; Disease Models, Animal ; emodin ; Emodin - pharmacology ; Inflammation Mediators - blood ; inhibitor ; Interleukin-18 - blood ; Interleukin-1beta - blood ; intestinal mucosa ; Intestinal Mucosa - drug effects ; Intestinal Mucosa - enzymology ; Intestinal Mucosa - ultrastructure ; Male ; mucosa;emodin;caspase-1 ; Pancreas - drug effects ; Pancreas - metabolism ; Pancreas - ultrastructure ; Pancreatitis - chemically induced ; Pancreatitis - drug therapy ; Pancreatitis - enzymology ; Pancreatitis - pathology ; pancreatitis;intestinal ; Rats, Sprague-Dawley ; severe ; severe acute pancreatitis ; Severity of Illness Index ; Signal Transduction - drug effects ; Taurocholic Acid</subject><ispartof>Hepatobiliary & pancreatic diseases international, 2017-08, Vol.16 (4), p.431-436</ispartof><rights>2017 The Editorial Board of Hepatobiliary & Pancreatic Diseases International</rights><rights>Copyright © 2017 The Editorial Board of Hepatobiliary & Pancreatic Diseases International. Published by Elsevier B.V. All rights reserved.</rights><rights>Copyright © Wanfang Data Co. Ltd. All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c481t-ef991cae7616ea02168757d3fa7efcddc5db4c7229054b9ed86ed50213a950f03</citedby><cites>FETCH-LOGICAL-c481t-ef991cae7616ea02168757d3fa7efcddc5db4c7229054b9ed86ed50213a950f03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/89801X/89801X.jpg</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1499387217600419$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28823375$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ning, Jian-Wen</creatorcontrib><creatorcontrib>Zhang, Yan</creatorcontrib><creatorcontrib>Yu, Mo-Sang</creatorcontrib><creatorcontrib>Gu, Meng-Li</creatorcontrib><creatorcontrib>Xu, Jia</creatorcontrib><creatorcontrib>Usman, Ali</creatorcontrib><creatorcontrib>Ji, Feng</creatorcontrib><title>Emodin alleviates intestinal mucosal injury in rats with severe acute pancreatitis via the caspase-1 inhibition</title><title>Hepatobiliary & pancreatic diseases international</title><addtitle>Hepatobiliary & Pancreatic Diseases International</addtitle><description>Severe acute pancreatitis (SAP) is a potentially lethal disease characterized by sudden onset, rapid progression,multiple organ failure and high mortality rate.[1-3] The underlying pathogenesis remains incompletely elucidated. As main anatomic and functional barrier, gut mucosa impairment is considered one of the major pathologies in SAP,[4, 5] which will increase intestinal permeability, bacteria translocation as well as release of endotoxin, inflammatory mediators and cytokines(IL-1β, IL-18).[6]Caspase-1 (IL-1β-converting enzyme/ICE) is a common intracellular cysteine protease that converts the precursors of IL-1β and IL-18 into active cytokines.[7, 8]Blockade of caspase-1 suppresses inflammatory mediator expressions, such as IL-1β and IL-18, which will alleviate inflammation cascade reaction and ameliorate the overall severity and mortality of patients with SAP.[9, 10]</description><subject>acute</subject><subject>Acute Disease</subject><subject>Animals</subject><subject>Caspase 1 - genetics</subject><subject>Caspase 1 - metabolism</subject><subject>Caspase Inhibitors - pharmacology</subject><subject>caspase-1 inhibitor</subject><subject>Disease Models, Animal</subject><subject>emodin</subject><subject>Emodin - pharmacology</subject><subject>Inflammation Mediators - blood</subject><subject>inhibitor</subject><subject>Interleukin-18 - blood</subject><subject>Interleukin-1beta - blood</subject><subject>intestinal mucosa</subject><subject>Intestinal Mucosa - drug effects</subject><subject>Intestinal Mucosa - enzymology</subject><subject>Intestinal Mucosa - ultrastructure</subject><subject>Male</subject><subject>mucosa;emodin;caspase-1</subject><subject>Pancreas - drug effects</subject><subject>Pancreas - metabolism</subject><subject>Pancreas - ultrastructure</subject><subject>Pancreatitis - chemically induced</subject><subject>Pancreatitis - drug therapy</subject><subject>Pancreatitis - enzymology</subject><subject>Pancreatitis - pathology</subject><subject>pancreatitis;intestinal</subject><subject>Rats, Sprague-Dawley</subject><subject>severe</subject><subject>severe acute pancreatitis</subject><subject>Severity of Illness Index</subject><subject>Signal Transduction - drug effects</subject><subject>Taurocholic Acid</subject><issn>1499-3872</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUFv3CAQhX1olaRJf0IrpF5SVW7BGDCnKorSpFKkHNKeEYbxLisbNoA32v31ZbObXHvhSfDNPGZeVX0i-DvBhP94JK2UNe1Ec0nEV45xS2r5rjp7uz6tPqS0wrjpOsZPqtOiDaWCnVXhZgrWeaTHETZOZ0jI-XJm5_WIptmEVNT51Ry3RVDUOaFnl5cowQYiIG3mDGitvYmgs8suodIH5SUgo9NaJ6hJKVy6vrwFf1G9H_SY4ONRz6u_v27-XN_V9w-3v6-v7mvTdiTXMEhJjAbBCQeNG8I7wYSlgxYwGGsNs31rRNNIzNpegu04WFY4qiXDA6bn1bdD32ftB-0XahXmWEZKarFa2G2_26ldg4nALSas0JcHeh3D01ymV5NLBsZRewhzUkRSLCnv-B5lB9TEkFKEQa2jm3TcKoLVPg31kobar10RoV7SULLUfT5azP0E9q3qNYoC_DwAUNaycRBVMg68AesimKxscP-1-HL82jL4xZMrU7-6CFzCF0J0nP4DfS2pWQ</recordid><startdate>20170815</startdate><enddate>20170815</enddate><creator>Ning, Jian-Wen</creator><creator>Zhang, Yan</creator><creator>Yu, Mo-Sang</creator><creator>Gu, Meng-Li</creator><creator>Xu, Jia</creator><creator>Usman, Ali</creator><creator>Ji, Feng</creator><general>Elsevier B.V</general><general>Division of Emergency, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China%Division of Gastroenterology, Yixing People's Hospital, Yixing 214200, China%Division of Gastroenterology, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>W91</scope><scope>~WA</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>2B.</scope><scope>4A8</scope><scope>92I</scope><scope>93N</scope><scope>PSX</scope><scope>TCJ</scope></search><sort><creationdate>20170815</creationdate><title>Emodin alleviates intestinal mucosal injury in rats with severe acute pancreatitis via the caspase-1 inhibition</title><author>Ning, Jian-Wen ; Zhang, Yan ; Yu, Mo-Sang ; Gu, Meng-Li ; Xu, Jia ; Usman, Ali ; Ji, Feng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c481t-ef991cae7616ea02168757d3fa7efcddc5db4c7229054b9ed86ed50213a950f03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>acute</topic><topic>Acute Disease</topic><topic>Animals</topic><topic>Caspase 1 - genetics</topic><topic>Caspase 1 - metabolism</topic><topic>Caspase Inhibitors - pharmacology</topic><topic>caspase-1 inhibitor</topic><topic>Disease Models, Animal</topic><topic>emodin</topic><topic>Emodin - pharmacology</topic><topic>Inflammation Mediators - blood</topic><topic>inhibitor</topic><topic>Interleukin-18 - blood</topic><topic>Interleukin-1beta - blood</topic><topic>intestinal mucosa</topic><topic>Intestinal Mucosa - drug effects</topic><topic>Intestinal Mucosa - enzymology</topic><topic>Intestinal Mucosa - ultrastructure</topic><topic>Male</topic><topic>mucosa;emodin;caspase-1</topic><topic>Pancreas - drug effects</topic><topic>Pancreas - metabolism</topic><topic>Pancreas - ultrastructure</topic><topic>Pancreatitis - chemically induced</topic><topic>Pancreatitis - drug therapy</topic><topic>Pancreatitis - enzymology</topic><topic>Pancreatitis - pathology</topic><topic>pancreatitis;intestinal</topic><topic>Rats, Sprague-Dawley</topic><topic>severe</topic><topic>severe acute pancreatitis</topic><topic>Severity of Illness Index</topic><topic>Signal Transduction - drug effects</topic><topic>Taurocholic Acid</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ning, Jian-Wen</creatorcontrib><creatorcontrib>Zhang, Yan</creatorcontrib><creatorcontrib>Yu, Mo-Sang</creatorcontrib><creatorcontrib>Gu, Meng-Li</creatorcontrib><creatorcontrib>Xu, Jia</creatorcontrib><creatorcontrib>Usman, Ali</creatorcontrib><creatorcontrib>Ji, Feng</creatorcontrib><collection>中文科技期刊数据库</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>中文科技期刊数据库-7.0平台</collection><collection>中文科技期刊数据库-医药卫生</collection><collection>中文科技期刊数据库- 镜像站点</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Wanfang Data Journals - Hong Kong</collection><collection>WANFANG Data Centre</collection><collection>Wanfang Data Journals</collection><collection>万方数据期刊 - 香港版</collection><collection>China Online Journals (COJ)</collection><collection>China Online Journals (COJ)</collection><jtitle>Hepatobiliary & pancreatic diseases international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ning, Jian-Wen</au><au>Zhang, Yan</au><au>Yu, Mo-Sang</au><au>Gu, Meng-Li</au><au>Xu, Jia</au><au>Usman, Ali</au><au>Ji, Feng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Emodin alleviates intestinal mucosal injury in rats with severe acute pancreatitis via the caspase-1 inhibition</atitle><jtitle>Hepatobiliary & pancreatic diseases international</jtitle><addtitle>Hepatobiliary & Pancreatic Diseases International</addtitle><date>2017-08-15</date><risdate>2017</risdate><volume>16</volume><issue>4</issue><spage>431</spage><epage>436</epage><pages>431-436</pages><issn>1499-3872</issn><abstract>Severe acute pancreatitis (SAP) is a potentially lethal disease characterized by sudden onset, rapid progression,multiple organ failure and high mortality rate.[1-3] The underlying pathogenesis remains incompletely elucidated. As main anatomic and functional barrier, gut mucosa impairment is considered one of the major pathologies in SAP,[4, 5] which will increase intestinal permeability, bacteria translocation as well as release of endotoxin, inflammatory mediators and cytokines(IL-1β, IL-18).[6]Caspase-1 (IL-1β-converting enzyme/ICE) is a common intracellular cysteine protease that converts the precursors of IL-1β and IL-18 into active cytokines.[7, 8]Blockade of caspase-1 suppresses inflammatory mediator expressions, such as IL-1β and IL-18, which will alleviate inflammation cascade reaction and ameliorate the overall severity and mortality of patients with SAP.[9, 10]</abstract><cop>Singapore</cop><pub>Elsevier B.V</pub><pmid>28823375</pmid><doi>10.1016/S1499-3872(17)60041-9</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Hepatobiliary & pancreatic diseases international, 2017-08, Vol.16 (4), p.431-436 |
| issn | 1499-3872 |
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| source | MEDLINE; Elsevier ScienceDirect Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | acute Acute Disease Animals Caspase 1 - genetics Caspase 1 - metabolism Caspase Inhibitors - pharmacology caspase-1 inhibitor Disease Models, Animal emodin Emodin - pharmacology Inflammation Mediators - blood inhibitor Interleukin-18 - blood Interleukin-1beta - blood intestinal mucosa Intestinal Mucosa - drug effects Intestinal Mucosa - enzymology Intestinal Mucosa - ultrastructure Male mucosa emodin caspase-1 Pancreas - drug effects Pancreas - metabolism Pancreas - ultrastructure Pancreatitis - chemically induced Pancreatitis - drug therapy Pancreatitis - enzymology Pancreatitis - pathology pancreatitis intestinal Rats, Sprague-Dawley severe severe acute pancreatitis Severity of Illness Index Signal Transduction - drug effects Taurocholic Acid |
| title | Emodin alleviates intestinal mucosal injury in rats with severe acute pancreatitis via the caspase-1 inhibition |
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