Circulating myeloid-derived suppressor cells in patients with pancreatic cancer
BACKGROUND： Myeloid-derived suppressor cells （MDSCs） are heterogeneous cell types that suppress T-cell responses in cancer patients and animal models, some MDSC subpopulations are increased in patients with pancreatic cancer. The present study was to investigate a specific subset of MDSCs in patient...
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| Veröffentlicht in: | Hepatobiliary & pancreatic diseases international 2016-02, Vol.15 (1), p.099-105 |
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| creator | Xu, Xiao-Dong Hu, Jun Wang, Min Peng, Feng Tian, Rui Guo, Xing-Jun Xie, Yu Qin, Ren-Yi |
| description | BACKGROUND： Myeloid-derived suppressor cells （MDSCs） are heterogeneous cell types that suppress T-cell responses in cancer patients and animal models, some MDSC subpopulations are increased in patients with pancreatic cancer. The present study was to investigate a specific subset of MDSCs in patients with pancreatic cancer and the mechanism of MDSCs increase in these patients. METHODS： Myeloid cells from whole blood were collected from 37 patients with pancreatic cancer, 17 with cholangiocarcinoma, and 47 healthy controls. Four pancreatic cancer cell lines were co- cultured with normal peripheral blood mononudear cells （PBMCs） to test the effect of tumor cells on the conversion of PBMCs to MDSCs. Levels of granulocyte-macrophage colony-stimulating factor （GM-CSF） and arginase activity in the plasma of cancer patients were analyzed by enzyme-linked immunosorbent assay. RESULTS： CD14＋/CD11b＋/HLA-DR MDSCs were increased in patients with pancreatic or bile duct cancer compared with those in healthy controls, and this increase was correlated with clinical cancer stage. Pancreatic cancer cell lines induced PBMCs to MDSCs in a dose-dependent manner. GM-CSF and arginase activity levels were significantly increased in the se rum of patients with pancreatic cancer. CONCLUSIONS： MDSCs were tumor related： tumor cells induced PBMCs to MDSCs in a dose-dependent manner and circulating CD14＋/CD11b＋/HLA-DR- MDSCs in pancreatic cancer patients were positively correlated with tumor burden. MDSCs might be useful markers for pancreatic cancer detection and progression. |
| doi_str_mv | 10.1016/S1499-3872(15)60413-1 |
| format | Article |
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The present study was to investigate a specific subset of MDSCs in patients with pancreatic cancer and the mechanism of MDSCs increase in these patients. METHODS： Myeloid cells from whole blood were collected from 37 patients with pancreatic cancer, 17 with cholangiocarcinoma, and 47 healthy controls. Four pancreatic cancer cell lines were co- cultured with normal peripheral blood mononudear cells （PBMCs） to test the effect of tumor cells on the conversion of PBMCs to MDSCs. Levels of granulocyte-macrophage colony-stimulating factor （GM-CSF） and arginase activity in the plasma of cancer patients were analyzed by enzyme-linked immunosorbent assay. RESULTS： CD14＋/CD11b＋/HLA-DR MDSCs were increased in patients with pancreatic or bile duct cancer compared with those in healthy controls, and this increase was correlated with clinical cancer stage. Pancreatic cancer cell lines induced PBMCs to MDSCs in a dose-dependent manner. GM-CSF and arginase activity levels were significantly increased in the se rum of patients with pancreatic cancer. CONCLUSIONS： MDSCs were tumor related： tumor cells induced PBMCs to MDSCs in a dose-dependent manner and circulating CD14＋/CD11b＋/HLA-DR- MDSCs in pancreatic cancer patients were positively correlated with tumor burden. MDSCs might be useful markers for pancreatic cancer detection and progression.</description><identifier>ISSN: 1499-3872</identifier><identifier>DOI: 10.1016/S1499-3872(15)60413-1</identifier><identifier>PMID: 26818550</identifier><language>eng</language><publisher>Singapore: Elsevier B.V</publisher><subject>Aged ; arginase ; Arginase - blood ; Bile Duct Neoplasms - blood ; Bile Duct Neoplasms - immunology ; Bile Duct Neoplasms - pathology ; Biomarkers, Tumor - blood ; Case-Control Studies ; CD11b Antigen - blood ; Cell Line, Tumor ; Cholangiocarcinoma - blood ; Cholangiocarcinoma - immunology ; Cholangiocarcinoma - pathology ; Coculture Techniques ; Endocrinology & Metabolism ; Female ; Gastroenterology and Hepatology ; GM-CSF ; granulocyte-macrophage colony-stimulating factor ; Granulocyte-Macrophage Colony-Stimulating Factor - blood ; HLA-DR Antigens - blood ; Humans ; Leukocytes, Mononuclear - immunology ; Leukocytes, Mononuclear - metabolism ; Lipopolysaccharide Receptors - blood ; Male ; Middle Aged ; Myeloid Cells - immunology ; Myeloid Cells - metabolism ; myeloid-derived suppressor cells ; pancreatic cancer ; Pancreatic Neoplasms - blood ; Pancreatic Neoplasms - immunology ; Pancreatic Neoplasms - pathology ; Tumor Burden ; Tumor Escape ; 外周血单个核细胞 ; 循环 ; 癌症患者 ; 粒细胞-巨噬细胞集落刺激因子 ; 细胞类型 ; 胰腺癌 ; 酶联免疫吸附测定法</subject><ispartof>Hepatobiliary & pancreatic diseases international, 2016-02, Vol.15 (1), p.099-105</ispartof><rights>The Editorial Board of Hepatobiliary & Pancreatic Diseases International</rights><rights>2016 The Editorial Board of Hepatobiliary & Pancreatic Diseases International</rights><rights>Copyright © Wanfang Data Co. Ltd. All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c535t-ada252896cf4c90882bd27575584b81e4859f6c731828cd3b261870e405860fa3</citedby><cites>FETCH-LOGICAL-c535t-ada252896cf4c90882bd27575584b81e4859f6c731828cd3b261870e405860fa3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/89801X/89801X.jpg</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1499387215604131$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26818550$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Xu, Xiao-Dong</creatorcontrib><creatorcontrib>Hu, Jun</creatorcontrib><creatorcontrib>Wang, Min</creatorcontrib><creatorcontrib>Peng, Feng</creatorcontrib><creatorcontrib>Tian, Rui</creatorcontrib><creatorcontrib>Guo, Xing-Jun</creatorcontrib><creatorcontrib>Xie, Yu</creatorcontrib><creatorcontrib>Qin, Ren-Yi</creatorcontrib><title>Circulating myeloid-derived suppressor cells in patients with pancreatic cancer</title><title>Hepatobiliary & pancreatic diseases international</title><addtitle>Hepatobiliary ＆ Pancreatic Diseases International</addtitle><description>BACKGROUND： Myeloid-derived suppressor cells （MDSCs） are heterogeneous cell types that suppress T-cell responses in cancer patients and animal models, some MDSC subpopulations are increased in patients with pancreatic cancer. The present study was to investigate a specific subset of MDSCs in patients with pancreatic cancer and the mechanism of MDSCs increase in these patients. METHODS： Myeloid cells from whole blood were collected from 37 patients with pancreatic cancer, 17 with cholangiocarcinoma, and 47 healthy controls. Four pancreatic cancer cell lines were co- cultured with normal peripheral blood mononudear cells （PBMCs） to test the effect of tumor cells on the conversion of PBMCs to MDSCs. Levels of granulocyte-macrophage colony-stimulating factor （GM-CSF） and arginase activity in the plasma of cancer patients were analyzed by enzyme-linked immunosorbent assay. RESULTS： CD14＋/CD11b＋/HLA-DR MDSCs were increased in patients with pancreatic or bile duct cancer compared with those in healthy controls, and this increase was correlated with clinical cancer stage. Pancreatic cancer cell lines induced PBMCs to MDSCs in a dose-dependent manner. GM-CSF and arginase activity levels were significantly increased in the se rum of patients with pancreatic cancer. CONCLUSIONS： MDSCs were tumor related： tumor cells induced PBMCs to MDSCs in a dose-dependent manner and circulating CD14＋/CD11b＋/HLA-DR- MDSCs in pancreatic cancer patients were positively correlated with tumor burden. MDSCs might be useful markers for pancreatic cancer detection and progression.</description><subject>Aged</subject><subject>arginase</subject><subject>Arginase - blood</subject><subject>Bile Duct Neoplasms - blood</subject><subject>Bile Duct Neoplasms - immunology</subject><subject>Bile Duct Neoplasms - pathology</subject><subject>Biomarkers, Tumor - blood</subject><subject>Case-Control Studies</subject><subject>CD11b Antigen - blood</subject><subject>Cell Line, Tumor</subject><subject>Cholangiocarcinoma - blood</subject><subject>Cholangiocarcinoma - immunology</subject><subject>Cholangiocarcinoma - pathology</subject><subject>Coculture Techniques</subject><subject>Endocrinology & Metabolism</subject><subject>Female</subject><subject>Gastroenterology and Hepatology</subject><subject>GM-CSF</subject><subject>granulocyte-macrophage colony-stimulating factor</subject><subject>Granulocyte-Macrophage Colony-Stimulating Factor - blood</subject><subject>HLA-DR Antigens - blood</subject><subject>Humans</subject><subject>Leukocytes, Mononuclear - immunology</subject><subject>Leukocytes, Mononuclear - metabolism</subject><subject>Lipopolysaccharide Receptors - blood</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Myeloid Cells - immunology</subject><subject>Myeloid Cells - metabolism</subject><subject>myeloid-derived suppressor cells</subject><subject>pancreatic cancer</subject><subject>Pancreatic Neoplasms - blood</subject><subject>Pancreatic Neoplasms - immunology</subject><subject>Pancreatic Neoplasms - pathology</subject><subject>Tumor Burden</subject><subject>Tumor Escape</subject><subject>外周血单个核细胞</subject><subject>循环</subject><subject>癌症患者</subject><subject>粒细胞-巨噬细胞集落刺激因子</subject><subject>细胞类型</subject><subject>胰腺癌</subject><subject>酶联免疫吸附测定法</subject><issn>1499-3872</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtv1DAURrMAtaXlJ4AiVkVVih_xIxsqNKJQqVIXwNpy7JvUQ8ZJ7aTVzK_HmQyzYMPK9tXxd32Ps-wdRtcYYf7pBy6rqqBSkEvMPnJUYlrgV9nZsXyavYlxjRCRkvGT7JRwiSVj6Cx7WLlgpk6Pzrf5Zgtd72xhIbhnsHmchiFAjH3IDXRdzJ3Ph4SCH2P-4sbHdPImQCqZ3KQthIvsdaO7CG8P63n26_brz9X34v7h293qy31hGGVjoa0mjMiKm6Y0FZKS1JYIJhiTZS0xlJJVDTeCYkmksbQmHEuBoERMctRoep5dLbkv2jfat2rdT8Gnjqpdt3Zb73ZqR5IblASJRF8u9BD6pwniqDYuziNpD_0UFRYclxzRkieULagJfYwBGjUEt9FhqzBSs221t61mrQoztbetcLr3_tBiqjdgj7f-qk7AzQJA0vLsIKhokkkD1gUwo7K9-2-Lz_8kmM55Z3T3G7YQjwawikShJWTOwGyfMAd8OMz22Pv2KX358ZmcC0EZ44L-AeIbsK0</recordid><startdate>20160201</startdate><enddate>20160201</enddate><creator>Xu, Xiao-Dong</creator><creator>Hu, Jun</creator><creator>Wang, Min</creator><creator>Peng, Feng</creator><creator>Tian, Rui</creator><creator>Guo, Xing-Jun</creator><creator>Xie, Yu</creator><creator>Qin, Ren-Yi</creator><general>Elsevier B.V</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>W91</scope><scope>~WA</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>2B.</scope><scope>4A8</scope><scope>92I</scope><scope>93N</scope><scope>PSX</scope><scope>TCJ</scope></search><sort><creationdate>20160201</creationdate><title>Circulating myeloid-derived suppressor cells in patients with pancreatic cancer</title><author>Xu, Xiao-Dong ; Hu, Jun ; Wang, Min ; Peng, Feng ; Tian, Rui ; Guo, Xing-Jun ; Xie, Yu ; Qin, Ren-Yi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c535t-ada252896cf4c90882bd27575584b81e4859f6c731828cd3b261870e405860fa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Aged</topic><topic>arginase</topic><topic>Arginase - blood</topic><topic>Bile Duct Neoplasms - blood</topic><topic>Bile Duct Neoplasms - immunology</topic><topic>Bile Duct Neoplasms - pathology</topic><topic>Biomarkers, Tumor - blood</topic><topic>Case-Control Studies</topic><topic>CD11b Antigen - blood</topic><topic>Cell Line, Tumor</topic><topic>Cholangiocarcinoma - blood</topic><topic>Cholangiocarcinoma - immunology</topic><topic>Cholangiocarcinoma - pathology</topic><topic>Coculture Techniques</topic><topic>Endocrinology & Metabolism</topic><topic>Female</topic><topic>Gastroenterology and Hepatology</topic><topic>GM-CSF</topic><topic>granulocyte-macrophage colony-stimulating factor</topic><topic>Granulocyte-Macrophage Colony-Stimulating Factor - blood</topic><topic>HLA-DR Antigens - blood</topic><topic>Humans</topic><topic>Leukocytes, Mononuclear - immunology</topic><topic>Leukocytes, Mononuclear - metabolism</topic><topic>Lipopolysaccharide Receptors - blood</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Myeloid Cells - immunology</topic><topic>Myeloid Cells - metabolism</topic><topic>myeloid-derived suppressor cells</topic><topic>pancreatic cancer</topic><topic>Pancreatic Neoplasms - blood</topic><topic>Pancreatic Neoplasms - immunology</topic><topic>Pancreatic Neoplasms - pathology</topic><topic>Tumor Burden</topic><topic>Tumor Escape</topic><topic>外周血单个核细胞</topic><topic>循环</topic><topic>癌症患者</topic><topic>粒细胞-巨噬细胞集落刺激因子</topic><topic>细胞类型</topic><topic>胰腺癌</topic><topic>酶联免疫吸附测定法</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Xu, Xiao-Dong</creatorcontrib><creatorcontrib>Hu, Jun</creatorcontrib><creatorcontrib>Wang, Min</creatorcontrib><creatorcontrib>Peng, Feng</creatorcontrib><creatorcontrib>Tian, Rui</creatorcontrib><creatorcontrib>Guo, Xing-Jun</creatorcontrib><creatorcontrib>Xie, Yu</creatorcontrib><creatorcontrib>Qin, Ren-Yi</creatorcontrib><collection>中文科技期刊数据库</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>中文科技期刊数据库-7.0平台</collection><collection>中文科技期刊数据库-医药卫生</collection><collection>中文科技期刊数据库- 镜像站点</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Wanfang Data Journals - Hong Kong</collection><collection>WANFANG Data Centre</collection><collection>Wanfang Data Journals</collection><collection>万方数据期刊 - 香港版</collection><collection>China Online Journals (COJ)</collection><collection>China Online Journals (COJ)</collection><jtitle>Hepatobiliary & pancreatic diseases international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Xu, Xiao-Dong</au><au>Hu, Jun</au><au>Wang, Min</au><au>Peng, Feng</au><au>Tian, Rui</au><au>Guo, Xing-Jun</au><au>Xie, Yu</au><au>Qin, Ren-Yi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Circulating myeloid-derived suppressor cells in patients with pancreatic cancer</atitle><jtitle>Hepatobiliary & pancreatic diseases international</jtitle><addtitle>Hepatobiliary ＆ Pancreatic Diseases International</addtitle><date>2016-02-01</date><risdate>2016</risdate><volume>15</volume><issue>1</issue><spage>099</spage><epage>105</epage><pages>099-105</pages><issn>1499-3872</issn><abstract>BACKGROUND： Myeloid-derived suppressor cells （MDSCs） are heterogeneous cell types that suppress T-cell responses in cancer patients and animal models, some MDSC subpopulations are increased in patients with pancreatic cancer. The present study was to investigate a specific subset of MDSCs in patients with pancreatic cancer and the mechanism of MDSCs increase in these patients. METHODS： Myeloid cells from whole blood were collected from 37 patients with pancreatic cancer, 17 with cholangiocarcinoma, and 47 healthy controls. Four pancreatic cancer cell lines were co- cultured with normal peripheral blood mononudear cells （PBMCs） to test the effect of tumor cells on the conversion of PBMCs to MDSCs. Levels of granulocyte-macrophage colony-stimulating factor （GM-CSF） and arginase activity in the plasma of cancer patients were analyzed by enzyme-linked immunosorbent assay. RESULTS： CD14＋/CD11b＋/HLA-DR MDSCs were increased in patients with pancreatic or bile duct cancer compared with those in healthy controls, and this increase was correlated with clinical cancer stage. Pancreatic cancer cell lines induced PBMCs to MDSCs in a dose-dependent manner. GM-CSF and arginase activity levels were significantly increased in the se rum of patients with pancreatic cancer. CONCLUSIONS： MDSCs were tumor related： tumor cells induced PBMCs to MDSCs in a dose-dependent manner and circulating CD14＋/CD11b＋/HLA-DR- MDSCs in pancreatic cancer patients were positively correlated with tumor burden. MDSCs might be useful markers for pancreatic cancer detection and progression.</abstract><cop>Singapore</cop><pub>Elsevier B.V</pub><pmid>26818550</pmid><doi>10.1016/S1499-3872(15)60413-1</doi><tpages>7</tpages></addata></record> |
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| subjects | Aged arginase Arginase - blood Bile Duct Neoplasms - blood Bile Duct Neoplasms - immunology Bile Duct Neoplasms - pathology Biomarkers, Tumor - blood Case-Control Studies CD11b Antigen - blood Cell Line, Tumor Cholangiocarcinoma - blood Cholangiocarcinoma - immunology Cholangiocarcinoma - pathology Coculture Techniques Endocrinology & Metabolism Female Gastroenterology and Hepatology GM-CSF granulocyte-macrophage colony-stimulating factor Granulocyte-Macrophage Colony-Stimulating Factor - blood HLA-DR Antigens - blood Humans Leukocytes, Mononuclear - immunology Leukocytes, Mononuclear - metabolism Lipopolysaccharide Receptors - blood Male Middle Aged Myeloid Cells - immunology Myeloid Cells - metabolism myeloid-derived suppressor cells pancreatic cancer Pancreatic Neoplasms - blood Pancreatic Neoplasms - immunology Pancreatic Neoplasms - pathology Tumor Burden Tumor Escape 外周血单个核细胞 循环 癌症患者 粒细胞-巨噬细胞集落刺激因子 细胞类型 胰腺癌 酶联免疫吸附测定法 |
| title | Circulating myeloid-derived suppressor cells in patients with pancreatic cancer |
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