CD4＋CXCR5＋ T cells activate CD27＋IgG＋ B cells via IL-21 in patients with hepatitis C virus infection

BACKGROUND： Chronic hepatitis C virus （HCV） infection causes the skewing and activation of B cell subsets, but the characteristics of IgG＋ B cells in patients with chronic hepa- titis C （CHC） infection have not been thoroughly elucidated. CD4＋CXCR5＋ follicular helper T （Tfh） cells, via interleukin （...

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Veröffentlicht in:	Hepatobiliary & pancreatic diseases international 2016-02, Vol.15 (1), p.55-64
Hauptverfasser:	Kong, Fan-Yun, Feng, Bo, Zhang, Heng-Hui, Rao, Hui-Ying, Wang, Jiang-Hua, Cong, Xu, Wei, Lai
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Apoptosis B-Lymphocytes - immunology B-Lymphocytes - metabolism B7-2 Antigen - blood B7-2 Antigen - immunology Biomarkers - blood B细胞 Case-Control Studies CD4 CD4+CXCR5+ T cells CD4-CD8 Ratio CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - metabolism Cell Communication Cells, Cultured chronic hepatitis C Coculture Techniques Endocrinology & Metabolism fas Receptor - blood fas Receptor - immunology Female Flow Cytometry Gastroenterology and Hepatology Hepatitis C, Chronic - blood Hepatitis C, Chronic - diagnosis Hepatitis C, Chronic - immunology Humans IgG+ B cells IL-21 Immunoglobulin G - blood Immunoglobulin G - immunology Interleukins - blood Interleukins - immunology Lymphocyte Activation Male Middle Aged Phenotype Receptors, CXCR5 - blood Receptors, CXCR5 - immunology Signal Transduction Tumor Necrosis Factor Receptor Superfamily, Member 7 - blood Tumor Necrosis Factor Receptor Superfamily, Member 7 - immunology T细胞活化丙型肝炎病毒患者抗体病毒感染酶联免疫吸附分析
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