SERUM CONCENTRATIONS OF HYALURONIC ACID, PROCOLLAGEN TYPE Ⅲ NH2-TERMINAL PEPTIDE, AND LAMININ IN PATIENTS WITH CHRONIC CONGESTIVE HEART FAILURE
Objective To explore the role of serum fibrotic indices including hyaluronic acid （HA）, procollagen type Ⅲ NH2-terminal peptide （PCIIIP）, and laminin （LN） in assessing the severity of myocardial fibrosis in chronic congestive heart failure （CHF）. Methods Serum levels of HA, PCIIIP, and LN in 39 pati...
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| Veröffentlicht in: | Chinese medical sciences journal 2006-09, Vol.21 (3), p.175-178 |
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| creator | Li, Gang Yan, Qing-bo Wei, Liang-ming |
| description | Objective To explore the role of serum fibrotic indices including hyaluronic acid （HA）, procollagen type Ⅲ NH2-terminal peptide （PCIIIP）, and laminin （LN） in assessing the severity of myocardial fibrosis in chronic congestive heart failure （CHF）.
Methods Serum levels of HA, PCIIIP, and LN in 39 patients with CHF E [14 with New York Heart Association （NYHA） functional class II, 21 with class Ⅲ, 4 with class Ⅳ] and in 46 patients with NYHA functional class I were assessed by radioimmunoassay.
Results The serum concentrations of HA, PCMP, and LN were 359.75 ± 84.59 μg/L, 77.88 ± 24. 67 μg/L, 86. 73 ± 23.90 μg/L in CHF group, and 211.60 ±54. 80 μg/L, 64.82 ±23.99 μg/L, 82. 26 ±23.98 μg/L in NYHA functional class Ⅰ group, respectively. The HA level was significantly higher in CHF patients as compared with NYHA functional class Ⅰ group （ P 〈 0.05 ）. However, no difference was found in the levels of PCIIIP and LN between CHF group and NYHA functional class Ⅰ group. The serum HA concentration was negatively correlated with left ventricular ejection fraction （ r = - 0.71, P 〈 0.05 ）.
Conclusion Serum HA level may act as an indicator for myocardial fibrosis. |
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Methods Serum levels of HA, PCIIIP, and LN in 39 patients with CHF E [14 with New York Heart Association （NYHA） functional class II, 21 with class Ⅲ, 4 with class Ⅳ] and in 46 patients with NYHA functional class I were assessed by radioimmunoassay.
Results The serum concentrations of HA, PCMP, and LN were 359.75 ± 84.59 μg/L, 77.88 ± 24. 67 μg/L, 86. 73 ± 23.90 μg/L in CHF group, and 211.60 ±54. 80 μg/L, 64.82 ±23.99 μg/L, 82. 26 ±23.98 μg/L in NYHA functional class Ⅰ group, respectively. The HA level was significantly higher in CHF patients as compared with NYHA functional class Ⅰ group （ P 〈 0.05 ）. However, no difference was found in the levels of PCIIIP and LN between CHF group and NYHA functional class Ⅰ group. The serum HA concentration was negatively correlated with left ventricular ejection fraction （ r = - 0.71, P 〈 0.05 ）.
Conclusion Serum HA level may act as an indicator for myocardial fibrosis.</description><identifier>ISSN: 1001-9294</identifier><identifier>PMID: 17086740</identifier><language>eng</language><publisher>China: Division of Cardiology,Department of Geriatrics,the First Affiliated Hospital,Chongqing University of Medical Sciences,Chongqing 400016%Department of Nuclear Medicine,the Second Affiliated Hospital,Chongqing University of Medical Sciences,Chongqing 400010</publisher><subject>Aged ; Aged, 80 and over ; Biomarkers - blood ; Collagen Type III - blood ; Female ; Fibrosis - blood ; Heart Failure - blood ; Humans ; Hyaluronic Acid - blood ; Laminin - blood ; Male ; Middle Aged ; Myocardium - pathology ; Severity of Illness Index ; 慢性充血性心力衰竭 ; 浓聚物 ; 缩氨酸 ; 胶原蛋白</subject><ispartof>Chinese medical sciences journal, 2006-09, Vol.21 (3), p.175-178</ispartof><rights>Copyright © Wanfang Data Co. Ltd. All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/86798X/86798X.jpg</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17086740$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Gang</creatorcontrib><creatorcontrib>Yan, Qing-bo</creatorcontrib><creatorcontrib>Wei, Liang-ming</creatorcontrib><title>SERUM CONCENTRATIONS OF HYALURONIC ACID, PROCOLLAGEN TYPE Ⅲ NH2-TERMINAL PEPTIDE, AND LAMININ IN PATIENTS WITH CHRONIC CONGESTIVE HEART FAILURE</title><title>Chinese medical sciences journal</title><addtitle>Chinese Medical Sciences Journal</addtitle><description>Objective To explore the role of serum fibrotic indices including hyaluronic acid （HA）, procollagen type Ⅲ NH2-terminal peptide （PCIIIP）, and laminin （LN） in assessing the severity of myocardial fibrosis in chronic congestive heart failure （CHF）.
Methods Serum levels of HA, PCIIIP, and LN in 39 patients with CHF E [14 with New York Heart Association （NYHA） functional class II, 21 with class Ⅲ, 4 with class Ⅳ] and in 46 patients with NYHA functional class I were assessed by radioimmunoassay.
Results The serum concentrations of HA, PCMP, and LN were 359.75 ± 84.59 μg/L, 77.88 ± 24. 67 μg/L, 86. 73 ± 23.90 μg/L in CHF group, and 211.60 ±54. 80 μg/L, 64.82 ±23.99 μg/L, 82. 26 ±23.98 μg/L in NYHA functional class Ⅰ group, respectively. The HA level was significantly higher in CHF patients as compared with NYHA functional class Ⅰ group （ P 〈 0.05 ）. However, no difference was found in the levels of PCIIIP and LN between CHF group and NYHA functional class Ⅰ group. The serum HA concentration was negatively correlated with left ventricular ejection fraction （ r = - 0.71, P 〈 0.05 ）.
Conclusion Serum HA level may act as an indicator for myocardial fibrosis.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biomarkers - blood</subject><subject>Collagen Type III - blood</subject><subject>Female</subject><subject>Fibrosis - blood</subject><subject>Heart Failure - blood</subject><subject>Humans</subject><subject>Hyaluronic Acid - blood</subject><subject>Laminin - blood</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Myocardium - pathology</subject><subject>Severity of Illness Index</subject><subject>慢性充血性心力衰竭</subject><subject>浓聚物</subject><subject>缩氨酸</subject><subject>胶原蛋白</subject><issn>1001-9294</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kN9KwzAUh3uh-Gf6ChK80BsLSdqmzWXosjVQ09JlilclzVLd3Lq5OsQH8AF8BR_NJzEyhQMHDt_5fpxz4J0gCJFPMQ2PvdO-X0AICUrCI-8YxTAhcQhPvM8Jr6a3IC1kyqWqmBKFnIBiBLIHlk-rQooUsFQMb0BZFWmR52zMJVAPJQffH19AZthXvLoVkuWg5KUSQ34DmByCnLmhkMBV6axOPgH3QmUgzfZWFznmEyXuOMg4qxQYMeES-Zl32Oplb8__-sCbjrhKMz8vxiJluW8QCqhvIEYYGR1HISKGunNgm1gaIh3TmYmIaWGjZxGMY0iDMAohIU2SBNaROJo1OBh413vvm-5a3T3Wi_Vu27nE2qz6RW2x-xYMoNseeFd7crNdv-xs_1qv5r2xy6Xu7HrX1yRBKA7pr_LiD9w1KzurN9v5Sm_f6_93O-ByD5indff4MnepjTbP7Xxpa4wTSgJCgh8XO3lS</recordid><startdate>200609</startdate><enddate>200609</enddate><creator>Li, Gang</creator><creator>Yan, Qing-bo</creator><creator>Wei, Liang-ming</creator><general>Division of Cardiology,Department of Geriatrics,the First Affiliated Hospital,Chongqing University of Medical Sciences,Chongqing 400016%Department of Nuclear Medicine,the Second Affiliated Hospital,Chongqing University of Medical Sciences,Chongqing 400010</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>W91</scope><scope>~WA</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope><scope>2B.</scope><scope>4A8</scope><scope>92I</scope><scope>93N</scope><scope>PSX</scope><scope>TCJ</scope></search><sort><creationdate>200609</creationdate><title>SERUM CONCENTRATIONS OF HYALURONIC ACID, PROCOLLAGEN TYPE Ⅲ NH2-TERMINAL PEPTIDE, AND LAMININ IN PATIENTS WITH CHRONIC CONGESTIVE HEART FAILURE</title><author>Li, Gang ; Yan, Qing-bo ; Wei, Liang-ming</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1139-c02121ca75416c98670f8e941a79dc56cf0bad5077093454066b883e98625db23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biomarkers - blood</topic><topic>Collagen Type III - blood</topic><topic>Female</topic><topic>Fibrosis - blood</topic><topic>Heart Failure - blood</topic><topic>Humans</topic><topic>Hyaluronic Acid - blood</topic><topic>Laminin - blood</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Myocardium - pathology</topic><topic>Severity of Illness Index</topic><topic>慢性充血性心力衰竭</topic><topic>浓聚物</topic><topic>缩氨酸</topic><topic>胶原蛋白</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Gang</creatorcontrib><creatorcontrib>Yan, Qing-bo</creatorcontrib><creatorcontrib>Wei, Liang-ming</creatorcontrib><collection>中文科技期刊数据库</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>中文科技期刊数据库-7.0平台</collection><collection>中文科技期刊数据库-医药卫生</collection><collection>中文科技期刊数据库- 镜像站点</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>Wanfang Data Journals - Hong Kong</collection><collection>WANFANG Data Centre</collection><collection>Wanfang Data Journals</collection><collection>万方数据期刊 - 香港版</collection><collection>China Online Journals (COJ)</collection><collection>China Online Journals (COJ)</collection><jtitle>Chinese medical sciences journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Gang</au><au>Yan, Qing-bo</au><au>Wei, Liang-ming</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>SERUM CONCENTRATIONS OF HYALURONIC ACID, PROCOLLAGEN TYPE Ⅲ NH2-TERMINAL PEPTIDE, AND LAMININ IN PATIENTS WITH CHRONIC CONGESTIVE HEART FAILURE</atitle><jtitle>Chinese medical sciences journal</jtitle><addtitle>Chinese Medical Sciences Journal</addtitle><date>2006-09</date><risdate>2006</risdate><volume>21</volume><issue>3</issue><spage>175</spage><epage>178</epage><pages>175-178</pages><issn>1001-9294</issn><abstract>Objective To explore the role of serum fibrotic indices including hyaluronic acid （HA）, procollagen type Ⅲ NH2-terminal peptide （PCIIIP）, and laminin （LN） in assessing the severity of myocardial fibrosis in chronic congestive heart failure （CHF）.
Methods Serum levels of HA, PCIIIP, and LN in 39 patients with CHF E [14 with New York Heart Association （NYHA） functional class II, 21 with class Ⅲ, 4 with class Ⅳ] and in 46 patients with NYHA functional class I were assessed by radioimmunoassay.
Results The serum concentrations of HA, PCMP, and LN were 359.75 ± 84.59 μg/L, 77.88 ± 24. 67 μg/L, 86. 73 ± 23.90 μg/L in CHF group, and 211.60 ±54. 80 μg/L, 64.82 ±23.99 μg/L, 82. 26 ±23.98 μg/L in NYHA functional class Ⅰ group, respectively. The HA level was significantly higher in CHF patients as compared with NYHA functional class Ⅰ group （ P 〈 0.05 ）. However, no difference was found in the levels of PCIIIP and LN between CHF group and NYHA functional class Ⅰ group. The serum HA concentration was negatively correlated with left ventricular ejection fraction （ r = - 0.71, P 〈 0.05 ）.
Conclusion Serum HA level may act as an indicator for myocardial fibrosis.</abstract><cop>China</cop><pub>Division of Cardiology,Department of Geriatrics,the First Affiliated Hospital,Chongqing University of Medical Sciences,Chongqing 400016%Department of Nuclear Medicine,the Second Affiliated Hospital,Chongqing University of Medical Sciences,Chongqing 400010</pub><pmid>17086740</pmid><tpages>4</tpages></addata></record> |
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| subjects | Aged Aged, 80 and over Biomarkers - blood Collagen Type III - blood Female Fibrosis - blood Heart Failure - blood Humans Hyaluronic Acid - blood Laminin - blood Male Middle Aged Myocardium - pathology Severity of Illness Index 慢性充血性心力衰竭 浓聚物 缩氨酸 胶原蛋白 |
| title | SERUM CONCENTRATIONS OF HYALURONIC ACID, PROCOLLAGEN TYPE Ⅲ NH2-TERMINAL PEPTIDE, AND LAMININ IN PATIENTS WITH CHRONIC CONGESTIVE HEART FAILURE |
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