DIAGNOSTIC VALUE OF SERUM INSULIN—LIKE GROWTH FACTOR BINDING PROTEIN—3 IN CHILDREN WITH OR WITHOUT GROWTH HORMONE DEFICIENCY
Objective:To study the value of serum insulin-like growth factor binding protein-3 (IGFBP-3) levels in differential diagnosis of growth hormone deficiency(GHD).Methods:To measure serum IGFBP-3 levels by RIA in normal children and adolescents,GHD children and short-stature children without (GHD).Meth...
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| Veröffentlicht in: | Chinese medical sciences journal 2002-09, Vol.17 (3), p.160-163 |
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| description | Objective:To study the value of serum insulin-like growth factor binding protein-3 (IGFBP-3) levels in differential diagnosis of growth hormone deficiency(GHD).Methods:To measure serum IGFBP-3 levels by RIA in normal children and adolescents,GHD children and short-stature children without (GHD).Methods:To measure serum IGFBP-3 levels by RIA in normal children and adolescents,GHD children and short-stature children without GHD.Results.Serum level of IGFBP-3 in 129 children with untreated GHD and with no pubertal development was 1.6±0.9mg/L,which was less than that in normal group of the same age,but overlapped with the normal children in Tanner stage I.After six-month treatment with recombinant human growth hormone(rhGH),serum level of IGFBP-3 in 59 GHD significantly increased from 1.3±0.7mg/L to 2.7±0.9mg/L,accompanied by an increase of body heights,growth velocities and serum level of IGF-1.Serum level of IGFBP-3 in 55 shortstature children without GHD was 3.3±2.2mg/L,which was not significantly different from that in normal group.Conclusion:Serum IGFBP-3 level can reflect the status of GH secretion in children with GHD and is a useful marker for differential diagnosis of GHD. |
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All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/86798X/86798X.jpg</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12901539$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>覃舒文 史轶蘩 等</creatorcontrib><title>DIAGNOSTIC VALUE OF SERUM INSULIN—LIKE GROWTH FACTOR BINDING PROTEIN—3 IN CHILDREN WITH OR WITHOUT GROWTH HORMONE DEFICIENCY</title><title>Chinese medical sciences journal</title><addtitle>Chinese Medical Sciences Journal</addtitle><description>Objective:To study the value of serum insulin-like growth factor binding protein-3 (IGFBP-3) levels in differential diagnosis of growth hormone deficiency(GHD).Methods:To measure serum IGFBP-3 levels by RIA in normal children and adolescents,GHD children and short-stature children without (GHD).Methods:To measure serum IGFBP-3 levels by RIA in normal children and adolescents,GHD children and short-stature children without GHD.Results.Serum level of IGFBP-3 in 129 children with untreated GHD and with no pubertal development was 1.6±0.9mg/L,which was less than that in normal group of the same age,but overlapped with the normal children in Tanner stage I.After six-month treatment with recombinant human growth hormone(rhGH),serum level of IGFBP-3 in 59 GHD significantly increased from 1.3±0.7mg/L to 2.7±0.9mg/L,accompanied by an increase of body heights,growth velocities and serum level of IGF-1.Serum level of IGFBP-3 in 55 shortstature children without GHD was 3.3±2.2mg/L,which was not significantly different from that in normal group.Conclusion:Serum IGFBP-3 level can reflect the status of GH secretion in children with GHD and is a useful marker for differential diagnosis of GHD.</description><subject>Adolescent</subject><subject>Biomarkers - blood</subject><subject>Body Height - drug effects</subject><subject>Child</subject><subject>Diagnosis, Differential</subject><subject>Female</subject><subject>Human Growth Hormone - deficiency</subject><subject>Human Growth Hormone - therapeutic use</subject><subject>Humans</subject><subject>Insulin-Like Growth Factor Binding Protein 3 - blood</subject><subject>Insulin-Like Growth Factor I - metabolism</subject><subject>Male</subject><subject>Recombinant Proteins - therapeutic use</subject><subject>生长激素缺乏</subject><subject>胰岛素类生长因子结合蛋白－3</subject><issn>1001-9294</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo10E9PgzAYBnAOGjenX8HUi56WtKVQekQoWyOjhoGLJ1Kg6ObG_iAx3vYh_IR-EtFtp-fye94nec-MPoIQDRlmpGdcNs0CQmgjh1wYPYQZRJbJ-sbeF-4oktNEeODZDVMOZACmPE4nQETTNBTRz_47FI8cjGI5S8YgcL1ExuBBRL6IRuAplgn_R2ZXAN5YhH7MIzATne3cX8o0ObXHMp7IiAOfB8ITPPJerozzSi0bfX3MgZEGPPHGw1COhOeGwwI5kA4rpEhul0TbGjMzd0qmiWVVChc0tytsl06hTItWhFKFc6pyRHOqCbIhdcqygubAuD_c_VR1perXbLFud3W3mBWrZpFpDCGGJoS0k3cHudmtt61uPrLVvCn0cqlqvW6bjGKH2RbBHbw5wjZf6TLb7OYrtfvKTt_twO0BFG_r-nU771ZzVbxX86XOKHEwo8z8BSXQd7c</recordid><startdate>200209</startdate><enddate>200209</enddate><creator>覃舒文 史轶蘩 等</creator><general>Department of Endocrinology, PUMC Hospital, CAMS and PUMC, Beijing 100730</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>W91</scope><scope>~WA</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope><scope>2B.</scope><scope>4A8</scope><scope>92I</scope><scope>93N</scope><scope>PSX</scope><scope>TCJ</scope></search><sort><creationdate>200209</creationdate><title>DIAGNOSTIC VALUE OF SERUM INSULIN—LIKE GROWTH FACTOR BINDING PROTEIN—3 IN CHILDREN WITH OR WITHOUT GROWTH HORMONE DEFICIENCY</title><author>覃舒文 史轶蘩 等</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1807-f1a4b6d4e6e293b8d9e455fa2c7b6f26d8ca357f477a2b7ab17b7e416078ddf03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adolescent</topic><topic>Biomarkers - blood</topic><topic>Body Height - drug effects</topic><topic>Child</topic><topic>Diagnosis, Differential</topic><topic>Female</topic><topic>Human Growth Hormone - deficiency</topic><topic>Human Growth Hormone - therapeutic use</topic><topic>Humans</topic><topic>Insulin-Like Growth Factor Binding Protein 3 - blood</topic><topic>Insulin-Like Growth Factor I - metabolism</topic><topic>Male</topic><topic>Recombinant Proteins - therapeutic use</topic><topic>生长激素缺乏</topic><topic>胰岛素类生长因子结合蛋白－3</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>覃舒文 史轶蘩 等</creatorcontrib><collection>中文科技期刊数据库</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>中文科技期刊数据库-7.0平台</collection><collection>中文科技期刊数据库-医药卫生</collection><collection>中文科技期刊数据库- 镜像站点</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>Wanfang Data Journals - Hong Kong</collection><collection>WANFANG Data Centre</collection><collection>Wanfang Data Journals</collection><collection>万方数据期刊 - 香港版</collection><collection>China Online Journals (COJ)</collection><collection>China Online Journals (COJ)</collection><jtitle>Chinese medical sciences journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>覃舒文 史轶蘩 等</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>DIAGNOSTIC VALUE OF SERUM INSULIN—LIKE GROWTH FACTOR BINDING PROTEIN—3 IN CHILDREN WITH OR WITHOUT GROWTH HORMONE DEFICIENCY</atitle><jtitle>Chinese medical sciences journal</jtitle><addtitle>Chinese Medical Sciences Journal</addtitle><date>2002-09</date><risdate>2002</risdate><volume>17</volume><issue>3</issue><spage>160</spage><epage>163</epage><pages>160-163</pages><issn>1001-9294</issn><abstract>Objective:To study the value of serum insulin-like growth factor binding protein-3 (IGFBP-3) levels in differential diagnosis of growth hormone deficiency(GHD).Methods:To measure serum IGFBP-3 levels by RIA in normal children and adolescents,GHD children and short-stature children without (GHD).Methods:To measure serum IGFBP-3 levels by RIA in normal children and adolescents,GHD children and short-stature children without GHD.Results.Serum level of IGFBP-3 in 129 children with untreated GHD and with no pubertal development was 1.6±0.9mg/L,which was less than that in normal group of the same age,but overlapped with the normal children in Tanner stage I.After six-month treatment with recombinant human growth hormone(rhGH),serum level of IGFBP-3 in 59 GHD significantly increased from 1.3±0.7mg/L to 2.7±0.9mg/L,accompanied by an increase of body heights,growth velocities and serum level of IGF-1.Serum level of IGFBP-3 in 55 shortstature children without GHD was 3.3±2.2mg/L,which was not significantly different from that in normal group.Conclusion:Serum IGFBP-3 level can reflect the status of GH secretion in children with GHD and is a useful marker for differential diagnosis of GHD.</abstract><cop>China</cop><pub>Department of Endocrinology, PUMC Hospital, CAMS and PUMC, Beijing 100730</pub><pmid>12901539</pmid><tpages>4</tpages></addata></record> |
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| subjects | Adolescent Biomarkers - blood Body Height - drug effects Child Diagnosis, Differential Female Human Growth Hormone - deficiency Human Growth Hormone - therapeutic use Humans Insulin-Like Growth Factor Binding Protein 3 - blood Insulin-Like Growth Factor I - metabolism Male Recombinant Proteins - therapeutic use 生长激素缺乏 胰岛素类生长因子结合蛋白－3 |
| title | DIAGNOSTIC VALUE OF SERUM INSULIN—LIKE GROWTH FACTOR BINDING PROTEIN—3 IN CHILDREN WITH OR WITHOUT GROWTH HORMONE DEFICIENCY |
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