Hepatitis B Immunoprophylactic Failure and Characteristics of the Hepatitis B Virus Gene in Mother-Infant Pairs in Parts of China
Objective To determine the hepatitis B immunoprophylactic failure rate in infants born to hepatitis B virus （HBV） infected mothers and to characterize HBV genes. Methods HBV-serological testing was conducted for pregnant women and infants. The complete genomes of 30 HBV isolates were sequenced, and...
Gespeichert in:
| Veröffentlicht in: | Biomedical and environmental sciences 2016-11, Vol.29 (11), p.790-801 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 801 |
|---|---|
| container_issue | 11 |
| container_start_page | 790 |
| container_title | Biomedical and environmental sciences |
| container_volume | 29 |
| creator | YIN, Wen Jiao SHEN, Li Ping WANG, Fu Zhen ZHANG, Guo Min ZHENG, Hui WANG, Feng LIU, Tie Zhu MENG, Qing Ling YI, Yao CUI, Fu Qiang BI, Sheng Li |
| description | Objective To determine the hepatitis B immunoprophylactic failure rate in infants born to hepatitis B virus （HBV） infected mothers and to characterize HBV genes. Methods HBV-serological testing was conducted for pregnant women and infants. The complete genomes of 30 HBV isolates were sequenced, and genetic characteristics were analyzed using MEGA 5 software. Results The immunoprophylactic failure rate for infants who had completed the scheduled hepatitis B vaccination program was 5.76% （32/556）. High sequence homology （99.8%-100%） was observed in 8 of the 10 mother-infant pairs. We identified 19 subgenotype C2 strains, 9 subgenotype B2 strains, and 2 subgenotype Cl strains. Three serotypes were detected： adr （19/30）, adw （9/30）, and ayw （2/30）. The frequency of amino acid mutation of the ＇a＇ determinant region was 16.67% （5/30）, including that of Q129H, F134Y,S136Y, and G145E. We detected 67 amino acid mutations in the basal core promoter, precore, and core regions of the genome. Conclusion The immunoprophylactic failure rate in infants born to HBV-infected mothers is low in the regions of China examined during this study. Moreover, HBV mutation in the ＇a＇ determinant region could not account for immunoprophylactic failure for all infants. |
| doi_str_mv | 10.3967/bes2016.106 |
| format | Article |
| fullrecord | <record><control><sourceid>wanfang_jour_proqu</sourceid><recordid>TN_cdi_wanfang_journals_bes201611003</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><cqvip_id>670926492</cqvip_id><wanfj_id>bes201611003</wanfj_id><els_id>S089539881630126X</els_id><sourcerecordid>bes201611003</sourcerecordid><originalsourceid>FETCH-LOGICAL-c313t-5d704c8f0a4cb19768a76b421d17491e699cd1d32a34121f733d18f832208d893</originalsourceid><addsrcrecordid>eNpNUcFu3CAQRVWrZrvtqfcKVT304oQBbMOxWTXJSqmSQ5MrYgHHRDbeAG6VY_48bHdX6gnNzHtv3jwQ-gzklMmmPdu4RAk0p0CaN2hBKfCKgCRv0YIIWVdMCnGCPqT0SAgHycV7dEJbKQUT9QK9XLmtzj77hM_xehznMG3jtO2fB22yN_hC-2GODutg8arXsXRd9KmMEp46nHuH_1e493FO-NIFh33Av6Yyj9U6dDpkfKt9TLv2rY75H3vV-6A_onedHpL7dHiX6O7i5-_VVXV9c7le_biuDAOWq9q2hBvREc3NBmTbCN02G07BQssluEZKY8EyqhkHCl3LmAXRCUYpEVZItkTf9rp_9c7Pg3qc5hjKRnUIEIAQVmDf97ASw9PsUlajT8YNgw5umpMCUQMjrC2mlujLATpvRmfVNvpRx2d1TLcA6j3Albv-eBdVMt4F46yPzmRlJ6-AqN0vHk2Uuim8r3ue6afw8OSL2aN20xJJGy4pewWERpeW</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1851303731</pqid></control><display><type>article</type><title>Hepatitis B Immunoprophylactic Failure and Characteristics of the Hepatitis B Virus Gene in Mother-Infant Pairs in Parts of China</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Access via ScienceDirect (Elsevier)</source><source>Alma/SFX Local Collection</source><creator>YIN, Wen Jiao ; SHEN, Li Ping ; WANG, Fu Zhen ; ZHANG, Guo Min ; ZHENG, Hui ; WANG, Feng ; LIU, Tie Zhu ; MENG, Qing Ling ; YI, Yao ; CUI, Fu Qiang ; BI, Sheng Li</creator><creatorcontrib>YIN, Wen Jiao ; SHEN, Li Ping ; WANG, Fu Zhen ; ZHANG, Guo Min ; ZHENG, Hui ; WANG, Feng ; LIU, Tie Zhu ; MENG, Qing Ling ; YI, Yao ; CUI, Fu Qiang ; BI, Sheng Li</creatorcontrib><description>Objective To determine the hepatitis B immunoprophylactic failure rate in infants born to hepatitis B virus （HBV） infected mothers and to characterize HBV genes. Methods HBV-serological testing was conducted for pregnant women and infants. The complete genomes of 30 HBV isolates were sequenced, and genetic characteristics were analyzed using MEGA 5 software. Results The immunoprophylactic failure rate for infants who had completed the scheduled hepatitis B vaccination program was 5.76% （32/556）. High sequence homology （99.8%-100%） was observed in 8 of the 10 mother-infant pairs. We identified 19 subgenotype C2 strains, 9 subgenotype B2 strains, and 2 subgenotype Cl strains. Three serotypes were detected： adr （19/30）, adw （9/30）, and ayw （2/30）. The frequency of amino acid mutation of the ＇a＇ determinant region was 16.67% （5/30）, including that of Q129H, F134Y,S136Y, and G145E. We detected 67 amino acid mutations in the basal core promoter, precore, and core regions of the genome. Conclusion The immunoprophylactic failure rate in infants born to HBV-infected mothers is low in the regions of China examined during this study. Moreover, HBV mutation in the ＇a＇ determinant region could not account for immunoprophylactic failure for all infants.</description><identifier>ISSN: 0895-3988</identifier><identifier>EISSN: 2214-0190</identifier><identifier>DOI: 10.3967/bes2016.106</identifier><identifier>PMID: 27998385</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Adult ; Animals ; China - epidemiology ; CHO Cells ; Cricetinae ; Cricetulus ; Female ; Gene characteristics ; Hepatitis B - congenital ; Hepatitis B - epidemiology ; Hepatitis B - prevention & control ; Hepatitis B - transmission ; Hepatitis B Vaccines - therapeutic use ; Hepatitis B virus - genetics ; Humans ; Immune escape ; Infant, Newborn ; Infectious Disease Transmission, Vertical ; Mother-to-infant transmission ; Mutation ; Phylogeny ; Pregnancy ; Scheduled vaccination ; Treatment Failure ; Young Adult ; ‘a’ determinant mutation ; 中国地区 ; 乙型肝炎病毒 ; 乙肝 ; 免疫预防 ; 基因组测序 ; 病毒基因 ; 病毒感染 ; 血清学检测</subject><ispartof>Biomedical and environmental sciences, 2016-11, Vol.29 (11), p.790-801</ispartof><rights>2016 The Editorial Board of Biomedical and Environmental Sciences</rights><rights>Copyright © 2016 The Editorial Board of Biomedical and Environmental Sciences. Published by China CDC. All rights reserved.</rights><rights>Copyright © Wanfang Data Co. Ltd. All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/84046X/84046X.jpg</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.3967/bes2016.106$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27928,27929,45999</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27998385$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>YIN, Wen Jiao</creatorcontrib><creatorcontrib>SHEN, Li Ping</creatorcontrib><creatorcontrib>WANG, Fu Zhen</creatorcontrib><creatorcontrib>ZHANG, Guo Min</creatorcontrib><creatorcontrib>ZHENG, Hui</creatorcontrib><creatorcontrib>WANG, Feng</creatorcontrib><creatorcontrib>LIU, Tie Zhu</creatorcontrib><creatorcontrib>MENG, Qing Ling</creatorcontrib><creatorcontrib>YI, Yao</creatorcontrib><creatorcontrib>CUI, Fu Qiang</creatorcontrib><creatorcontrib>BI, Sheng Li</creatorcontrib><title>Hepatitis B Immunoprophylactic Failure and Characteristics of the Hepatitis B Virus Gene in Mother-Infant Pairs in Parts of China</title><title>Biomedical and environmental sciences</title><addtitle>Biomedical and Environmental Sciences</addtitle><description>Objective To determine the hepatitis B immunoprophylactic failure rate in infants born to hepatitis B virus （HBV） infected mothers and to characterize HBV genes. Methods HBV-serological testing was conducted for pregnant women and infants. The complete genomes of 30 HBV isolates were sequenced, and genetic characteristics were analyzed using MEGA 5 software. Results The immunoprophylactic failure rate for infants who had completed the scheduled hepatitis B vaccination program was 5.76% （32/556）. High sequence homology （99.8%-100%） was observed in 8 of the 10 mother-infant pairs. We identified 19 subgenotype C2 strains, 9 subgenotype B2 strains, and 2 subgenotype Cl strains. Three serotypes were detected： adr （19/30）, adw （9/30）, and ayw （2/30）. The frequency of amino acid mutation of the ＇a＇ determinant region was 16.67% （5/30）, including that of Q129H, F134Y,S136Y, and G145E. We detected 67 amino acid mutations in the basal core promoter, precore, and core regions of the genome. Conclusion The immunoprophylactic failure rate in infants born to HBV-infected mothers is low in the regions of China examined during this study. Moreover, HBV mutation in the ＇a＇ determinant region could not account for immunoprophylactic failure for all infants.</description><subject>Adult</subject><subject>Animals</subject><subject>China - epidemiology</subject><subject>CHO Cells</subject><subject>Cricetinae</subject><subject>Cricetulus</subject><subject>Female</subject><subject>Gene characteristics</subject><subject>Hepatitis B - congenital</subject><subject>Hepatitis B - epidemiology</subject><subject>Hepatitis B - prevention & control</subject><subject>Hepatitis B - transmission</subject><subject>Hepatitis B Vaccines - therapeutic use</subject><subject>Hepatitis B virus - genetics</subject><subject>Humans</subject><subject>Immune escape</subject><subject>Infant, Newborn</subject><subject>Infectious Disease Transmission, Vertical</subject><subject>Mother-to-infant transmission</subject><subject>Mutation</subject><subject>Phylogeny</subject><subject>Pregnancy</subject><subject>Scheduled vaccination</subject><subject>Treatment Failure</subject><subject>Young Adult</subject><subject>‘a’ determinant mutation</subject><subject>中国地区</subject><subject>乙型肝炎病毒</subject><subject>乙肝</subject><subject>免疫预防</subject><subject>基因组测序</subject><subject>病毒基因</subject><subject>病毒感染</subject><subject>血清学检测</subject><issn>0895-3988</issn><issn>2214-0190</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNUcFu3CAQRVWrZrvtqfcKVT304oQBbMOxWTXJSqmSQ5MrYgHHRDbeAG6VY_48bHdX6gnNzHtv3jwQ-gzklMmmPdu4RAk0p0CaN2hBKfCKgCRv0YIIWVdMCnGCPqT0SAgHycV7dEJbKQUT9QK9XLmtzj77hM_xehznMG3jtO2fB22yN_hC-2GODutg8arXsXRd9KmMEp46nHuH_1e493FO-NIFh33Av6Yyj9U6dDpkfKt9TLv2rY75H3vV-6A_onedHpL7dHiX6O7i5-_VVXV9c7le_biuDAOWq9q2hBvREc3NBmTbCN02G07BQssluEZKY8EyqhkHCl3LmAXRCUYpEVZItkTf9rp_9c7Pg3qc5hjKRnUIEIAQVmDf97ASw9PsUlajT8YNgw5umpMCUQMjrC2mlujLATpvRmfVNvpRx2d1TLcA6j3Albv-eBdVMt4F46yPzmRlJ6-AqN0vHk2Uuim8r3ue6afw8OSL2aN20xJJGy4pewWERpeW</recordid><startdate>20161101</startdate><enddate>20161101</enddate><creator>YIN, Wen Jiao</creator><creator>SHEN, Li Ping</creator><creator>WANG, Fu Zhen</creator><creator>ZHANG, Guo Min</creator><creator>ZHENG, Hui</creator><creator>WANG, Feng</creator><creator>LIU, Tie Zhu</creator><creator>MENG, Qing Ling</creator><creator>YI, Yao</creator><creator>CUI, Fu Qiang</creator><creator>BI, Sheng Li</creator><general>Elsevier B.V</general><general>National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China%Department of Immunization Planning Program, Chinese Center for Disease Control and Prevention, Beijing 102206, China</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>W91</scope><scope>~WA</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope><scope>2B.</scope><scope>4A8</scope><scope>92I</scope><scope>93N</scope><scope>PSX</scope><scope>TCJ</scope></search><sort><creationdate>20161101</creationdate><title>Hepatitis B Immunoprophylactic Failure and Characteristics of the Hepatitis B Virus Gene in Mother-Infant Pairs in Parts of China</title><author>YIN, Wen Jiao ; SHEN, Li Ping ; WANG, Fu Zhen ; ZHANG, Guo Min ; ZHENG, Hui ; WANG, Feng ; LIU, Tie Zhu ; MENG, Qing Ling ; YI, Yao ; CUI, Fu Qiang ; BI, Sheng Li</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c313t-5d704c8f0a4cb19768a76b421d17491e699cd1d32a34121f733d18f832208d893</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adult</topic><topic>Animals</topic><topic>China - epidemiology</topic><topic>CHO Cells</topic><topic>Cricetinae</topic><topic>Cricetulus</topic><topic>Female</topic><topic>Gene characteristics</topic><topic>Hepatitis B - congenital</topic><topic>Hepatitis B - epidemiology</topic><topic>Hepatitis B - prevention & control</topic><topic>Hepatitis B - transmission</topic><topic>Hepatitis B Vaccines - therapeutic use</topic><topic>Hepatitis B virus - genetics</topic><topic>Humans</topic><topic>Immune escape</topic><topic>Infant, Newborn</topic><topic>Infectious Disease Transmission, Vertical</topic><topic>Mother-to-infant transmission</topic><topic>Mutation</topic><topic>Phylogeny</topic><topic>Pregnancy</topic><topic>Scheduled vaccination</topic><topic>Treatment Failure</topic><topic>Young Adult</topic><topic>‘a’ determinant mutation</topic><topic>中国地区</topic><topic>乙型肝炎病毒</topic><topic>乙肝</topic><topic>免疫预防</topic><topic>基因组测序</topic><topic>病毒基因</topic><topic>病毒感染</topic><topic>血清学检测</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>YIN, Wen Jiao</creatorcontrib><creatorcontrib>SHEN, Li Ping</creatorcontrib><creatorcontrib>WANG, Fu Zhen</creatorcontrib><creatorcontrib>ZHANG, Guo Min</creatorcontrib><creatorcontrib>ZHENG, Hui</creatorcontrib><creatorcontrib>WANG, Feng</creatorcontrib><creatorcontrib>LIU, Tie Zhu</creatorcontrib><creatorcontrib>MENG, Qing Ling</creatorcontrib><creatorcontrib>YI, Yao</creatorcontrib><creatorcontrib>CUI, Fu Qiang</creatorcontrib><creatorcontrib>BI, Sheng Li</creatorcontrib><collection>中文科技期刊数据库</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>中文科技期刊数据库-7.0平台</collection><collection>中文科技期刊数据库-医药卫生</collection><collection>中文科技期刊数据库- 镜像站点</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>Wanfang Data Journals - Hong Kong</collection><collection>WANFANG Data Centre</collection><collection>Wanfang Data Journals</collection><collection>万方数据期刊 - 香港版</collection><collection>China Online Journals (COJ)</collection><collection>China Online Journals (COJ)</collection><jtitle>Biomedical and environmental sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>YIN, Wen Jiao</au><au>SHEN, Li Ping</au><au>WANG, Fu Zhen</au><au>ZHANG, Guo Min</au><au>ZHENG, Hui</au><au>WANG, Feng</au><au>LIU, Tie Zhu</au><au>MENG, Qing Ling</au><au>YI, Yao</au><au>CUI, Fu Qiang</au><au>BI, Sheng Li</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hepatitis B Immunoprophylactic Failure and Characteristics of the Hepatitis B Virus Gene in Mother-Infant Pairs in Parts of China</atitle><jtitle>Biomedical and environmental sciences</jtitle><addtitle>Biomedical and Environmental Sciences</addtitle><date>2016-11-01</date><risdate>2016</risdate><volume>29</volume><issue>11</issue><spage>790</spage><epage>801</epage><pages>790-801</pages><issn>0895-3988</issn><eissn>2214-0190</eissn><abstract>Objective To determine the hepatitis B immunoprophylactic failure rate in infants born to hepatitis B virus （HBV） infected mothers and to characterize HBV genes. Methods HBV-serological testing was conducted for pregnant women and infants. The complete genomes of 30 HBV isolates were sequenced, and genetic characteristics were analyzed using MEGA 5 software. Results The immunoprophylactic failure rate for infants who had completed the scheduled hepatitis B vaccination program was 5.76% （32/556）. High sequence homology （99.8%-100%） was observed in 8 of the 10 mother-infant pairs. We identified 19 subgenotype C2 strains, 9 subgenotype B2 strains, and 2 subgenotype Cl strains. Three serotypes were detected： adr （19/30）, adw （9/30）, and ayw （2/30）. The frequency of amino acid mutation of the ＇a＇ determinant region was 16.67% （5/30）, including that of Q129H, F134Y,S136Y, and G145E. We detected 67 amino acid mutations in the basal core promoter, precore, and core regions of the genome. Conclusion The immunoprophylactic failure rate in infants born to HBV-infected mothers is low in the regions of China examined during this study. Moreover, HBV mutation in the ＇a＇ determinant region could not account for immunoprophylactic failure for all infants.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>27998385</pmid><doi>10.3967/bes2016.106</doi><tpages>12</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0895-3988 |
| ispartof | Biomedical and environmental sciences, 2016-11, Vol.29 (11), p.790-801 |
| issn | 0895-3988 2214-0190 |
| language | eng |
| recordid | cdi_wanfang_journals_bes201611003 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Access via ScienceDirect (Elsevier); Alma/SFX Local Collection |
| subjects | Adult Animals China - epidemiology CHO Cells Cricetinae Cricetulus Female Gene characteristics Hepatitis B - congenital Hepatitis B - epidemiology Hepatitis B - prevention & control Hepatitis B - transmission Hepatitis B Vaccines - therapeutic use Hepatitis B virus - genetics Humans Immune escape Infant, Newborn Infectious Disease Transmission, Vertical Mother-to-infant transmission Mutation Phylogeny Pregnancy Scheduled vaccination Treatment Failure Young Adult ‘a’ determinant mutation 中国地区 乙型肝炎病毒 乙肝 免疫预防 基因组测序 病毒基因 病毒感染 血清学检测 |
| title | Hepatitis B Immunoprophylactic Failure and Characteristics of the Hepatitis B Virus Gene in Mother-Infant Pairs in Parts of China |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-17T05%3A41%3A13IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-wanfang_jour_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Hepatitis%20B%20Immunoprophylactic%20Failure%20and%20Characteristics%20of%20the%20Hepatitis%20B%20Virus%20Gene%20in%20Mother-Infant%20Pairs%20in%20Parts%20of%20China&rft.jtitle=Biomedical%20and%20environmental%20sciences&rft.au=YIN,%20Wen%20Jiao&rft.date=2016-11-01&rft.volume=29&rft.issue=11&rft.spage=790&rft.epage=801&rft.pages=790-801&rft.issn=0895-3988&rft.eissn=2214-0190&rft_id=info:doi/10.3967/bes2016.106&rft_dat=%3Cwanfang_jour_proqu%3Ebes201611003%3C/wanfang_jour_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1851303731&rft_id=info:pmid/27998385&rft_cqvip_id=670926492&rft_wanfj_id=bes201611003&rft_els_id=S089539881630126X&rfr_iscdi=true |