Prevalence and Risk Factors of Primary Drug-Resistant Tuberculosis in China
Objective To investigate the prevalence of primary drug-resistant tuberculosis（TB） and associated risk factors in China. We also explored factors contributing to the transmission of multidrug-resistant tuberculosis（MDR-TB）. Methods A total of 2794 representative, Mycobacterium tuberculosis isolates...
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| Veröffentlicht in: | Biomedical and environmental sciences 2016-02, Vol.29 (2), p.91-98 |
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| creator | WANG, Sheng Fen Yang, ZHOU Yu, PANG Hui Wen, ZHENG Yan Lin, ZHAO |
| description | Objective To investigate the prevalence of primary drug-resistant tuberculosis（TB） and associated risk factors in China. We also explored factors contributing to the transmission of multidrug-resistant tuberculosis（MDR-TB）. Methods A total of 2794 representative, Mycobacterium tuberculosis isolates from treatment-naive patients were subjected to drug susceptibility testing, and risk factors for drug-resistant TB were analyzed. We also analyzed MDR-TB strain sublineages, drug-resistance-conferring mutations, and risk factors associated with clustered primary MDR strains. Results Among 2794 Mycobacterium tuberculosis isolates from treatment-naive patients, the prevalence of any resistance to first-line drugs was 33.2% and the prevalence of MDR-TB was 5.7%. We did not find any risk factors significantly associated with resistance to first-line drugs. The 93 primary MDR-TB isolates were classified into six sublineages, of which, 75（80.6%） isolates were the RD105-deleted Beijing lineage. The largest sublineage included 65（69.9%） isolates with concurrent deletions of RD105, RD207, and RD181. Twenty-nine（31.2%） primary MDR strains grouped in clusters; MDR isolates in clusters were more likely to have S531 L rpoB mutation. Conclusion This study indicates that primary drug-resistant TB and MDR-TB strains are prevalent in China, and multiple measures should be taken to address drug-resistant TB. |
| doi_str_mv | 10.3967/bes2016.010 |
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We also explored factors contributing to the transmission of multidrug-resistant tuberculosis（MDR-TB）. Methods A total of 2794 representative, Mycobacterium tuberculosis isolates from treatment-naive patients were subjected to drug susceptibility testing, and risk factors for drug-resistant TB were analyzed. We also analyzed MDR-TB strain sublineages, drug-resistance-conferring mutations, and risk factors associated with clustered primary MDR strains. Results Among 2794 Mycobacterium tuberculosis isolates from treatment-naive patients, the prevalence of any resistance to first-line drugs was 33.2% and the prevalence of MDR-TB was 5.7%. We did not find any risk factors significantly associated with resistance to first-line drugs. The 93 primary MDR-TB isolates were classified into six sublineages, of which, 75（80.6%） isolates were the RD105-deleted Beijing lineage. The largest sublineage included 65（69.9%） isolates with concurrent deletions of RD105, RD207, and RD181. Twenty-nine（31.2%） primary MDR strains grouped in clusters; MDR isolates in clusters were more likely to have S531 L rpoB mutation. Conclusion This study indicates that primary drug-resistant TB and MDR-TB strains are prevalent in China, and multiple measures should be taken to address drug-resistant TB.</description><identifier>ISSN: 0895-3988</identifier><identifier>EISSN: 2214-0190</identifier><identifier>DOI: 10.3967/bes2016.010</identifier><identifier>PMID: 27003166</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; China - epidemiology ; Drug Resistance, Multiple, Bacterial - genetics ; Female ; Humans ; Male ; Middle Aged ; Multi-drug resistant tuberculosis ; Mycobacterium tuberculosis ; Prevalence ; Primary drug resistance ; Risk Factors ; Tuberculosis, Multidrug-Resistant - epidemiology ; Tuberculosis, Multidrug-Resistant - transmission ; Young Adult ; 危险因素 ; 原发性 ; 患病率 ; 流行情况 ; 结核分枝杆菌 ; 耐药菌株 ; 肺结核 ; 药物敏感性试验</subject><ispartof>Biomedical and environmental sciences, 2016-02, Vol.29 (2), p.91-98</ispartof><rights>2016 The Editorial Board of Biomedical and Environmental Sciences</rights><rights>Copyright © 2016 The Editorial Board of Biomedical and Environmental Sciences. Published by China CDC. All rights reserved.</rights><rights>Copyright © Wanfang Data Co. Ltd. All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c355t-bddcc761473d67f8180cc680286008562dbfffbaa8947afb2e61d391c2f541c13</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/84046X/84046X.jpg</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0895398816300204$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27003166$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>WANG, Sheng Fen</creatorcontrib><creatorcontrib>Yang, ZHOU</creatorcontrib><creatorcontrib>Yu, PANG</creatorcontrib><creatorcontrib>Hui Wen, ZHENG</creatorcontrib><creatorcontrib>Yan Lin, ZHAO</creatorcontrib><title>Prevalence and Risk Factors of Primary Drug-Resistant Tuberculosis in China</title><title>Biomedical and environmental sciences</title><addtitle>Biomedical and Environmental Sciences</addtitle><description>Objective To investigate the prevalence of primary drug-resistant tuberculosis（TB） and associated risk factors in China. We also explored factors contributing to the transmission of multidrug-resistant tuberculosis（MDR-TB）. Methods A total of 2794 representative, Mycobacterium tuberculosis isolates from treatment-naive patients were subjected to drug susceptibility testing, and risk factors for drug-resistant TB were analyzed. We also analyzed MDR-TB strain sublineages, drug-resistance-conferring mutations, and risk factors associated with clustered primary MDR strains. Results Among 2794 Mycobacterium tuberculosis isolates from treatment-naive patients, the prevalence of any resistance to first-line drugs was 33.2% and the prevalence of MDR-TB was 5.7%. We did not find any risk factors significantly associated with resistance to first-line drugs. The 93 primary MDR-TB isolates were classified into six sublineages, of which, 75（80.6%） isolates were the RD105-deleted Beijing lineage. The largest sublineage included 65（69.9%） isolates with concurrent deletions of RD105, RD207, and RD181. Twenty-nine（31.2%） primary MDR strains grouped in clusters; MDR isolates in clusters were more likely to have S531 L rpoB mutation. Conclusion This study indicates that primary drug-resistant TB and MDR-TB strains are prevalent in China, and multiple measures should be taken to address drug-resistant TB.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>China - epidemiology</subject><subject>Drug Resistance, Multiple, Bacterial - genetics</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Multi-drug resistant tuberculosis</subject><subject>Mycobacterium tuberculosis</subject><subject>Prevalence</subject><subject>Primary drug resistance</subject><subject>Risk Factors</subject><subject>Tuberculosis, Multidrug-Resistant - epidemiology</subject><subject>Tuberculosis, Multidrug-Resistant - transmission</subject><subject>Young Adult</subject><subject>危险因素</subject><subject>原发性</subject><subject>患病率</subject><subject>流行情况</subject><subject>结核分枝杆菌</subject><subject>耐药菌株</subject><subject>肺结核</subject><subject>药物敏感性试验</subject><issn>0895-3988</issn><issn>2214-0190</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kc1P3DAQxa2qqCzQU--VVfXAJTC2E8c-Vlu2rYoEQtuz5fhj1zTrgJ2A-O_xKrunkUa_NzPvDUJfCFwxydvrzmUKhF8BgQ9oQSmpKyASPqIFCNlUTApxis5yfgSoiazFJ3RKWwBGOF-gv_fJvejeReOwjhY_hPwfr7QZh5Tx4PF9Cjud3vDPNG2qB5dDHnUc8XrqXDJTP5QGDhEvtyHqC3TidZ_d50M9R_9WN-vl7-r27tef5Y_byrCmGavOWmNaTuqWWd56QQQYwwVQwQFEw6ntvPed1kLWrfYddZxYJomhvqmJIewcfZ_nvuroddyox2FKsWxUhyiAAtCCXc7YUxqeJ5dHtQvZuL7X0Q1TVqRtG84akLKgXw_o1O2cVU-za3XMqQDNDLji6yW4pLIJ-9BsSM6Myg5BEVD7fxyPUOUfRfdt1pntEDfPoRx7nM15cc6AMfYOGQGFYg</recordid><startdate>20160201</startdate><enddate>20160201</enddate><creator>WANG, Sheng Fen</creator><creator>Yang, ZHOU</creator><creator>Yu, PANG</creator><creator>Hui Wen, ZHENG</creator><creator>Yan Lin, ZHAO</creator><general>Elsevier B.V</general><general>National Center for Tuberculosis Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206,China</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>W91</scope><scope>~WA</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope><scope>2B.</scope><scope>4A8</scope><scope>92I</scope><scope>93N</scope><scope>PSX</scope><scope>TCJ</scope></search><sort><creationdate>20160201</creationdate><title>Prevalence and Risk Factors of Primary Drug-Resistant Tuberculosis in China</title><author>WANG, Sheng Fen ; Yang, ZHOU ; Yu, PANG ; Hui Wen, ZHENG ; Yan Lin, ZHAO</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c355t-bddcc761473d67f8180cc680286008562dbfffbaa8947afb2e61d391c2f541c13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>China - epidemiology</topic><topic>Drug Resistance, Multiple, Bacterial - genetics</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Multi-drug resistant tuberculosis</topic><topic>Mycobacterium tuberculosis</topic><topic>Prevalence</topic><topic>Primary drug resistance</topic><topic>Risk Factors</topic><topic>Tuberculosis, Multidrug-Resistant - epidemiology</topic><topic>Tuberculosis, Multidrug-Resistant - transmission</topic><topic>Young Adult</topic><topic>危险因素</topic><topic>原发性</topic><topic>患病率</topic><topic>流行情况</topic><topic>结核分枝杆菌</topic><topic>耐药菌株</topic><topic>肺结核</topic><topic>药物敏感性试验</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>WANG, Sheng Fen</creatorcontrib><creatorcontrib>Yang, ZHOU</creatorcontrib><creatorcontrib>Yu, PANG</creatorcontrib><creatorcontrib>Hui Wen, ZHENG</creatorcontrib><creatorcontrib>Yan Lin, ZHAO</creatorcontrib><collection>中文科技期刊数据库</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>中文科技期刊数据库-7.0平台</collection><collection>中文科技期刊数据库-医药卫生</collection><collection>中文科技期刊数据库- 镜像站点</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>Wanfang Data Journals - Hong Kong</collection><collection>WANFANG Data Centre</collection><collection>Wanfang Data Journals</collection><collection>万方数据期刊 - 香港版</collection><collection>China Online Journals (COJ)</collection><collection>China Online Journals (COJ)</collection><jtitle>Biomedical and environmental sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>WANG, Sheng Fen</au><au>Yang, ZHOU</au><au>Yu, PANG</au><au>Hui Wen, ZHENG</au><au>Yan Lin, ZHAO</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prevalence and Risk Factors of Primary Drug-Resistant Tuberculosis in China</atitle><jtitle>Biomedical and environmental sciences</jtitle><addtitle>Biomedical and Environmental Sciences</addtitle><date>2016-02-01</date><risdate>2016</risdate><volume>29</volume><issue>2</issue><spage>91</spage><epage>98</epage><pages>91-98</pages><issn>0895-3988</issn><eissn>2214-0190</eissn><abstract>Objective To investigate the prevalence of primary drug-resistant tuberculosis（TB） and associated risk factors in China. We also explored factors contributing to the transmission of multidrug-resistant tuberculosis（MDR-TB）. Methods A total of 2794 representative, Mycobacterium tuberculosis isolates from treatment-naive patients were subjected to drug susceptibility testing, and risk factors for drug-resistant TB were analyzed. We also analyzed MDR-TB strain sublineages, drug-resistance-conferring mutations, and risk factors associated with clustered primary MDR strains. Results Among 2794 Mycobacterium tuberculosis isolates from treatment-naive patients, the prevalence of any resistance to first-line drugs was 33.2% and the prevalence of MDR-TB was 5.7%. We did not find any risk factors significantly associated with resistance to first-line drugs. The 93 primary MDR-TB isolates were classified into six sublineages, of which, 75（80.6%） isolates were the RD105-deleted Beijing lineage. The largest sublineage included 65（69.9%） isolates with concurrent deletions of RD105, RD207, and RD181. Twenty-nine（31.2%） primary MDR strains grouped in clusters; MDR isolates in clusters were more likely to have S531 L rpoB mutation. Conclusion This study indicates that primary drug-resistant TB and MDR-TB strains are prevalent in China, and multiple measures should be taken to address drug-resistant TB.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>27003166</pmid><doi>10.3967/bes2016.010</doi><tpages>8</tpages></addata></record> |
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| subjects | Adolescent Adult Aged Aged, 80 and over China - epidemiology Drug Resistance, Multiple, Bacterial - genetics Female Humans Male Middle Aged Multi-drug resistant tuberculosis Mycobacterium tuberculosis Prevalence Primary drug resistance Risk Factors Tuberculosis, Multidrug-Resistant - epidemiology Tuberculosis, Multidrug-Resistant - transmission Young Adult 危险因素 原发性 患病率 流行情况 结核分枝杆菌 耐药菌株 肺结核 药物敏感性试验 |
| title | Prevalence and Risk Factors of Primary Drug-Resistant Tuberculosis in China |
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