Searching for a Schizophrenia Susceptibility Gene in the 22q11 Region
Objective To investigate a genetic association for schizophrenia within chromosome 22ql 1 in a Chinese Han population.Methods The PCR-based restriction fragment length polymorphism (PCR-RFLP) analysis was used to detect three singlen ucleotide polymorphisms (SNPs), rs165655 (A/G base change) and rs1...
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| Veröffentlicht in: | Biomedical and environmental sciences 2005-02, Vol.18 (1), p.31-35 |
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| creator | Xie, Lin Ju, Gui-Zhi Liu, Shu-Zheng Shi, Jie-Ping Yu, Ya-Qin Wei, Jun |
| description | Objective To investigate a genetic association for schizophrenia within chromosome 22ql 1 in a Chinese Han population.Methods The PCR-based restriction fragment length polymorphism (PCR-RFLP) analysis was used to detect three singlen ucleotide polymorphisms (SNPs), rs165655 (A/G base change) and rs165815 (C/T base change) present in the ARVCF(armadillo repeat gene deletion in velocardiofacial syndrome) locus, and rs756656 (A/C base change) in the LOC128979(expressed sequence tags, EST) locus, among 100 Chinese family trios consisting of fathers, mothers and affected offspring with schizophrenia. Genotype data were analyzed by using linkage disequilibrium (LD) methods including haplotype relative risk (HRR) analysis, transmission disequilibrium test (TDT) and haplotype transmission analysis. Results The genotype frequency distributions of three SNPs were all in Hardy-Weinberg equilibrium (P＞0.05). Both the HRR and the TDT analysis showed that rs 165815 was associated with schizophrenia (22=6.447, df=- 1, P=0.011 and X^2=6.313, df=1, P=0.012, respectively),whereas the other two SNPs did not show any allelic association. The haplotype transmission analysis showed a biased transmission for the rs165655-rs165815 haplotype system (X2=17.224, df=3, P=0.0006) and for the rs756656-rs165655-rs165815 hapoltype system (X^2=20.965, df=7, P=0.0038). Conclusion Either the ARVCF gene itself or a nearby locus may confer susceptibility to schizophrenia in a Chinese Han population. |
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Genotype data were analyzed by using linkage disequilibrium (LD) methods including haplotype relative risk (HRR) analysis, transmission disequilibrium test (TDT) and haplotype transmission analysis. Results The genotype frequency distributions of three SNPs were all in Hardy-Weinberg equilibrium (P＞0.05). Both the HRR and the TDT analysis showed that rs 165815 was associated with schizophrenia (22=6.447, df=- 1, P=0.011 and X^2=6.313, df=1, P=0.012, respectively),whereas the other two SNPs did not show any allelic association. The haplotype transmission analysis showed a biased transmission for the rs165655-rs165815 haplotype system (X2=17.224, df=3, P=0.0006) and for the rs756656-rs165655-rs165815 hapoltype system (X^2=20.965, df=7, P=0.0038). Conclusion Either the ARVCF gene itself or a nearby locus may confer susceptibility to schizophrenia in a Chinese Han population.</description><identifier>ISSN: 0895-3988</identifier><identifier>EISSN: 2214-0190</identifier><identifier>PMID: 15861775</identifier><language>eng</language><publisher>China: Research Center for Genomic Medicine & MH Radiobiology Research Unit,School of Public Health,Jilin University,Changchun 130021,Jilin,China</publisher><subject>22q11染色体 ; Adult ; Armadillo Domain Proteins ; Catechol O-Methyltransferase - genetics ; Cell Adhesion Molecules - genetics ; China ; Chromosomes, Human, Pair 22 - genetics ; Female ; Genetic Predisposition to Disease ; Haplotypes ; Humans ; Male ; Phosphoproteins - genetics ; Polymorphism, Single Nucleotide ; Schizophrenia - genetics ; 易感基因 ; 精神分裂症 ; 遗传因素</subject><ispartof>Biomedical and environmental sciences, 2005-02, Vol.18 (1), p.31-35</ispartof><rights>Copyright © Wanfang Data Co. Ltd. All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/84046X/84046X.jpg</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15861775$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Xie, Lin</creatorcontrib><creatorcontrib>Ju, Gui-Zhi</creatorcontrib><creatorcontrib>Liu, Shu-Zheng</creatorcontrib><creatorcontrib>Shi, Jie-Ping</creatorcontrib><creatorcontrib>Yu, Ya-Qin</creatorcontrib><creatorcontrib>Wei, Jun</creatorcontrib><title>Searching for a Schizophrenia Susceptibility Gene in the 22q11 Region</title><title>Biomedical and environmental sciences</title><addtitle>Biomedical and Environmental Sciences</addtitle><description>Objective To investigate a genetic association for schizophrenia within chromosome 22ql 1 in a Chinese Han population.Methods The PCR-based restriction fragment length polymorphism (PCR-RFLP) analysis was used to detect three singlen ucleotide polymorphisms (SNPs), rs165655 (A/G base change) and rs165815 (C/T base change) present in the ARVCF(armadillo repeat gene deletion in velocardiofacial syndrome) locus, and rs756656 (A/C base change) in the LOC128979(expressed sequence tags, EST) locus, among 100 Chinese family trios consisting of fathers, mothers and affected offspring with schizophrenia. Genotype data were analyzed by using linkage disequilibrium (LD) methods including haplotype relative risk (HRR) analysis, transmission disequilibrium test (TDT) and haplotype transmission analysis. Results The genotype frequency distributions of three SNPs were all in Hardy-Weinberg equilibrium (P＞0.05). Both the HRR and the TDT analysis showed that rs 165815 was associated with schizophrenia (22=6.447, df=- 1, P=0.011 and X^2=6.313, df=1, P=0.012, respectively),whereas the other two SNPs did not show any allelic association. The haplotype transmission analysis showed a biased transmission for the rs165655-rs165815 haplotype system (X2=17.224, df=3, P=0.0006) and for the rs756656-rs165655-rs165815 hapoltype system (X^2=20.965, df=7, P=0.0038). Conclusion Either the ARVCF gene itself or a nearby locus may confer susceptibility to schizophrenia in a Chinese Han population.</description><subject>22q11染色体</subject><subject>Adult</subject><subject>Armadillo Domain Proteins</subject><subject>Catechol O-Methyltransferase - genetics</subject><subject>Cell Adhesion Molecules - genetics</subject><subject>China</subject><subject>Chromosomes, Human, Pair 22 - genetics</subject><subject>Female</subject><subject>Genetic Predisposition to Disease</subject><subject>Haplotypes</subject><subject>Humans</subject><subject>Male</subject><subject>Phosphoproteins - genetics</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Schizophrenia - genetics</subject><subject>易感基因</subject><subject>精神分裂症</subject><subject>遗传因素</subject><issn>0895-3988</issn><issn>2214-0190</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo10NtKw0AQBuBFFFurryBBxLvAzmazh0sptQoFwep12GwmydZ0k-aA1Kd3ofVq-OFjhvkvyJwx4DEFTS_JnCqdxolWakZuhmFHKQfN1TWZQaoESJnOyWqLpre181VUtn1kom0Iv21X9-hdSNNgsRtd7ho3HqM1eoycj8YaI8YOANEHVq71t-SqNM2Ad-e5IF8vq8_la7x5X78tnzexZSIdY4M2VbqQNi9LC6pMC8tsQgGosZBwWSCUxvC8EIKB0txKi1wUWuaKA7OYLMjjae-P8aXxVbZrp96Hi1mOA6M0pUCpCOzpxLq-PUw4jNnehT-axnhspyETUmquhQzw_gynfI9F1vVub_pj9t9PAA8nYOvWV4dQU5Yb-126BgMCySWH5A_6PGxo</recordid><startdate>20050201</startdate><enddate>20050201</enddate><creator>Xie, Lin</creator><creator>Ju, Gui-Zhi</creator><creator>Liu, Shu-Zheng</creator><creator>Shi, Jie-Ping</creator><creator>Yu, Ya-Qin</creator><creator>Wei, Jun</creator><general>Research Center for Genomic Medicine & MH Radiobiology Research Unit,School of Public Health,Jilin University,Changchun 130021,Jilin,China</general><general>Schizophrenia Association of Great Britain,Institute of Biological Psychiatry,Bangor,UK</general><general>Postdoctoral Fellow of Institute of Genetics and Cytology,School of the Sciences,Northeast Normal University,China%Research Center for Genomic Medicine & MH Radiobiology Research Unit,School of Public Health,Jilin University,Changchun 130021,Jilin,China%Research Center for Genomic Medicine & MH Radiobiology Research Unit,School of Public Health,Jilin University,Changchun 130021,Jilin,China</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>W91</scope><scope>~WA</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope><scope>2B.</scope><scope>4A8</scope><scope>92I</scope><scope>93N</scope><scope>PSX</scope><scope>TCJ</scope></search><sort><creationdate>20050201</creationdate><title>Searching for a Schizophrenia Susceptibility Gene in the 22q11 Region</title><author>Xie, Lin ; Ju, Gui-Zhi ; Liu, Shu-Zheng ; Shi, Jie-Ping ; Yu, Ya-Qin ; Wei, Jun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c265t-aec589d7cbffc18f5dc2c30110ac1347de1faa4bd6621894c7ce46d97b8412ce3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>22q11染色体</topic><topic>Adult</topic><topic>Armadillo Domain Proteins</topic><topic>Catechol O-Methyltransferase - genetics</topic><topic>Cell Adhesion Molecules - genetics</topic><topic>China</topic><topic>Chromosomes, Human, Pair 22 - genetics</topic><topic>Female</topic><topic>Genetic Predisposition to Disease</topic><topic>Haplotypes</topic><topic>Humans</topic><topic>Male</topic><topic>Phosphoproteins - genetics</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Schizophrenia - genetics</topic><topic>易感基因</topic><topic>精神分裂症</topic><topic>遗传因素</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Xie, Lin</creatorcontrib><creatorcontrib>Ju, Gui-Zhi</creatorcontrib><creatorcontrib>Liu, Shu-Zheng</creatorcontrib><creatorcontrib>Shi, Jie-Ping</creatorcontrib><creatorcontrib>Yu, Ya-Qin</creatorcontrib><creatorcontrib>Wei, Jun</creatorcontrib><collection>中文科技期刊数据库</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>中文科技期刊数据库-7.0平台</collection><collection>中文科技期刊数据库-医药卫生</collection><collection>中文科技期刊数据库- 镜像站点</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>Wanfang Data Journals - Hong Kong</collection><collection>WANFANG Data Centre</collection><collection>Wanfang Data Journals</collection><collection>万方数据期刊 - 香港版</collection><collection>China Online Journals (COJ)</collection><collection>China Online Journals (COJ)</collection><jtitle>Biomedical and environmental sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Xie, Lin</au><au>Ju, Gui-Zhi</au><au>Liu, Shu-Zheng</au><au>Shi, Jie-Ping</au><au>Yu, Ya-Qin</au><au>Wei, Jun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Searching for a Schizophrenia Susceptibility Gene in the 22q11 Region</atitle><jtitle>Biomedical and environmental sciences</jtitle><addtitle>Biomedical and Environmental Sciences</addtitle><date>2005-02-01</date><risdate>2005</risdate><volume>18</volume><issue>1</issue><spage>31</spage><epage>35</epage><pages>31-35</pages><issn>0895-3988</issn><eissn>2214-0190</eissn><abstract>Objective To investigate a genetic association for schizophrenia within chromosome 22ql 1 in a Chinese Han population.Methods The PCR-based restriction fragment length polymorphism (PCR-RFLP) analysis was used to detect three singlen ucleotide polymorphisms (SNPs), rs165655 (A/G base change) and rs165815 (C/T base change) present in the ARVCF(armadillo repeat gene deletion in velocardiofacial syndrome) locus, and rs756656 (A/C base change) in the LOC128979(expressed sequence tags, EST) locus, among 100 Chinese family trios consisting of fathers, mothers and affected offspring with schizophrenia. Genotype data were analyzed by using linkage disequilibrium (LD) methods including haplotype relative risk (HRR) analysis, transmission disequilibrium test (TDT) and haplotype transmission analysis. Results The genotype frequency distributions of three SNPs were all in Hardy-Weinberg equilibrium (P＞0.05). Both the HRR and the TDT analysis showed that rs 165815 was associated with schizophrenia (22=6.447, df=- 1, P=0.011 and X^2=6.313, df=1, P=0.012, respectively),whereas the other two SNPs did not show any allelic association. The haplotype transmission analysis showed a biased transmission for the rs165655-rs165815 haplotype system (X2=17.224, df=3, P=0.0006) and for the rs756656-rs165655-rs165815 hapoltype system (X^2=20.965, df=7, P=0.0038). Conclusion Either the ARVCF gene itself or a nearby locus may confer susceptibility to schizophrenia in a Chinese Han population.</abstract><cop>China</cop><pub>Research Center for Genomic Medicine & MH Radiobiology Research Unit,School of Public Health,Jilin University,Changchun 130021,Jilin,China</pub><pmid>15861775</pmid><tpages>5</tpages></addata></record> |
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| subjects | 22q11染色体 Adult Armadillo Domain Proteins Catechol O-Methyltransferase - genetics Cell Adhesion Molecules - genetics China Chromosomes, Human, Pair 22 - genetics Female Genetic Predisposition to Disease Haplotypes Humans Male Phosphoproteins - genetics Polymorphism, Single Nucleotide Schizophrenia - genetics 易感基因 精神分裂症 遗传因素 |
| title | Searching for a Schizophrenia Susceptibility Gene in the 22q11 Region |
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