Silica Induced Early Fibrogenic Reaction in Lung of Mice Ameliorated by Nyctanthes arbortristis Extract
To investigate the pharmacological effect of Nyctanthes arbortrisis(NAT)leaf extract in the prevention of lung injury induced by silica particles.Method Lung injury was induced in Swiss mice through inhalation exposure to silica particles(
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| Veröffentlicht in: | Biomedical and environmental sciences 2002-09, Vol.15 (3), p.215-222 |
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| creator | Paul, Bhola Nath Prakash, Anand Kumar, Sirish Yadav, Ajay K Mani, U Saxena, Ashok K Sahu, Anand Prakash Lal, Kewal Dutta, Kalyan K |
| description | To investigate the pharmacological effect of Nyctanthes arbortrisis(NAT)leaf extract in the prevention of lung injury induced by silica particles.Method Lung injury was induced in Swiss mice through inhalation exposure to silica particles( |
| format | Article |
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India%Inhalation Toxicology Laboratory</publisher><subject>Administration, Oral ; Animals ; Bronchoalveolar Lavage Fluid ; Disease Models, Animal ; Enzyme-Linked Immunosorbent Assay ; Inhalation Exposure ; Male ; Mice ; NAT ; Oleaceae - chemistry ; Phytotherapy ; Plant Extracts - pharmacology ; Pulmonary Fibrosis - etiology ; Pulmonary Fibrosis - prevention & control ; Pulmonary Fibrosis - veterinary ; Silicon Dioxide - adverse effects ; Silicosis - prevention & control ; Silicosis - veterinary ; 提取物 ; 肺纤维化</subject><ispartof>Biomedical and environmental sciences, 2002-09, Vol.15 (3), p.215-222</ispartof><rights>Copyright © Wanfang Data Co. Ltd. All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/84046X/84046X.jpg</thumbnail><link.rule.ids>315,781,785</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12500662$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Paul, Bhola Nath</creatorcontrib><creatorcontrib>Prakash, Anand</creatorcontrib><creatorcontrib>Kumar, Sirish</creatorcontrib><creatorcontrib>Yadav, Ajay K</creatorcontrib><creatorcontrib>Mani, U</creatorcontrib><creatorcontrib>Saxena, Ashok K</creatorcontrib><creatorcontrib>Sahu, Anand Prakash</creatorcontrib><creatorcontrib>Lal, Kewal</creatorcontrib><creatorcontrib>Dutta, Kalyan K</creatorcontrib><title>Silica Induced Early Fibrogenic Reaction in Lung of Mice Ameliorated by Nyctanthes arbortristis Extract</title><title>Biomedical and environmental sciences</title><addtitle>Biomedical and Environmental Sciences</addtitle><description>To investigate the pharmacological effect of Nyctanthes arbortrisis(NAT)leaf extract in the prevention of lung injury induced by silica particles.Method Lung injury was induced in Swiss mice through inhalation exposure to silica particles(<5μ）using a Flow Past Nose Only Inhalation Chamber at the rate of-10mg/m^3 respirable mass for5h.Lung bronchoalveolar lavage(BAL)fluid collected between 48and 72hwas subjected to protein profiling by electrophoresis and cytokine evaluation by solid phase sandwich ELISA,Lung histopathology was performed to evaluate lung injury.Results Inhalation ofsilica increased the level of tumor necrosis factor-α（TNF-α），and of the 66and 63kDa peptides in the BAL fluid in comparison to sham-treated control.Pre-treatment of silica exposed mice with NAT leaf extract significantly prevented the accumulation of TNF-0633in the BAL fluid,but the 66and63kDapeptides remained unchanged.The extract was also effective in the prevention of silica-induced early fibrogenic reactions like congestion,edema and infiltration of nucleated cells in the interstitial alveolar spaces.and thickening of alveolar septa in mouse lung.Conclusion NAT leaf extract helps in bypassing silica induced initial lung injury in mice.</description><subject>Administration, Oral</subject><subject>Animals</subject><subject>Bronchoalveolar Lavage Fluid</subject><subject>Disease Models, Animal</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Inhalation Exposure</subject><subject>Male</subject><subject>Mice</subject><subject>NAT</subject><subject>Oleaceae - chemistry</subject><subject>Phytotherapy</subject><subject>Plant Extracts - pharmacology</subject><subject>Pulmonary Fibrosis - etiology</subject><subject>Pulmonary Fibrosis - prevention & control</subject><subject>Pulmonary Fibrosis - veterinary</subject><subject>Silicon Dioxide - adverse effects</subject><subject>Silicosis - prevention & control</subject><subject>Silicosis - veterinary</subject><subject>提取物</subject><subject>肺纤维化</subject><issn>0895-3988</issn><issn>2214-0190</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kF1LwzAUhoMobk7_gkTwtnDy0TS9HGPTwVTw47okadpldulMU3T_3sD06lyc5zwv7zlDU0oJz4CUcI6mIMs8Y6WUE3Q1DDsATkouL9GE0BxACDpF7ZvrnFF47evR2BovVeiOeOV06FvrncGvVpnoeo-dx5vRt7hv8JMzFs_3tnN9UDFd6SN-PpqofNzaAaug-xCDG6Ib8PInhmS4RheN6gZ78zdn6GO1fF88ZpuXh_VivskMFTRmhRI147LmlFhNCpnTQtWiASYl1XkOiqVqArjRnKUVlaVoCNeFVlpImQObofuT91v5Rvm22vVj8Cmx0nagABQYQJ6w2xN2GPXe1tUhuL0Kx-r_MQm4OwFm2_v2yyWTVuazcZ2tCiAcGGW_C1pp6g</recordid><startdate>20020901</startdate><enddate>20020901</enddate><creator>Paul, Bhola Nath</creator><creator>Prakash, Anand</creator><creator>Kumar, Sirish</creator><creator>Yadav, Ajay K</creator><creator>Mani, U</creator><creator>Saxena, Ashok K</creator><creator>Sahu, Anand Prakash</creator><creator>Lal, Kewal</creator><creator>Dutta, Kalyan K</creator><general>Industrial Toxicology Research Centre, M.G.Marg, Lucknow 226001, U.P. 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chemistry</topic><topic>Phytotherapy</topic><topic>Plant Extracts - pharmacology</topic><topic>Pulmonary Fibrosis - etiology</topic><topic>Pulmonary Fibrosis - prevention & control</topic><topic>Pulmonary Fibrosis - veterinary</topic><topic>Silicon Dioxide - adverse effects</topic><topic>Silicosis - prevention & control</topic><topic>Silicosis - veterinary</topic><topic>提取物</topic><topic>肺纤维化</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Paul, Bhola Nath</creatorcontrib><creatorcontrib>Prakash, Anand</creatorcontrib><creatorcontrib>Kumar, Sirish</creatorcontrib><creatorcontrib>Yadav, Ajay K</creatorcontrib><creatorcontrib>Mani, U</creatorcontrib><creatorcontrib>Saxena, Ashok K</creatorcontrib><creatorcontrib>Sahu, Anand Prakash</creatorcontrib><creatorcontrib>Lal, Kewal</creatorcontrib><creatorcontrib>Dutta, Kalyan K</creatorcontrib><collection>中文科技期刊数据库</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>中文科技期刊数据库-7.0平台</collection><collection>中文科技期刊数据库-医药卫生</collection><collection>中文科技期刊数据库- 镜像站点</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Wanfang Data Journals - Hong Kong</collection><collection>WANFANG Data Centre</collection><collection>Wanfang Data Journals</collection><collection>万方数据期刊 - 香港版</collection><collection>China Online Journals (COJ)</collection><collection>China Online Journals (COJ)</collection><jtitle>Biomedical and environmental sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Paul, Bhola Nath</au><au>Prakash, Anand</au><au>Kumar, Sirish</au><au>Yadav, Ajay K</au><au>Mani, U</au><au>Saxena, Ashok K</au><au>Sahu, Anand Prakash</au><au>Lal, Kewal</au><au>Dutta, Kalyan K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Silica Induced Early Fibrogenic Reaction in Lung of Mice Ameliorated by Nyctanthes arbortristis Extract</atitle><jtitle>Biomedical and environmental sciences</jtitle><addtitle>Biomedical and Environmental Sciences</addtitle><date>2002-09-01</date><risdate>2002</risdate><volume>15</volume><issue>3</issue><spage>215</spage><epage>222</epage><pages>215-222</pages><issn>0895-3988</issn><eissn>2214-0190</eissn><abstract>To investigate the pharmacological effect of Nyctanthes arbortrisis(NAT)leaf extract in the prevention of lung injury induced by silica particles.Method Lung injury was induced in Swiss mice through inhalation exposure to silica particles(<5μ）using a Flow Past Nose Only Inhalation Chamber at the rate of-10mg/m^3 respirable mass for5h.Lung bronchoalveolar lavage(BAL)fluid collected between 48and 72hwas subjected to protein profiling by electrophoresis and cytokine evaluation by solid phase sandwich ELISA,Lung histopathology was performed to evaluate lung injury.Results Inhalation ofsilica increased the level of tumor necrosis factor-α（TNF-α），and of the 66and 63kDa peptides in the BAL fluid in comparison to sham-treated control.Pre-treatment of silica exposed mice with NAT leaf extract significantly prevented the accumulation of TNF-0633in the BAL fluid,but the 66and63kDapeptides remained unchanged.The extract was also effective in the prevention of silica-induced early fibrogenic reactions like congestion,edema and infiltration of nucleated cells in the interstitial alveolar spaces.and thickening of alveolar septa in mouse lung.Conclusion NAT leaf extract helps in bypassing silica induced initial lung injury in mice.</abstract><cop>China</cop><pub>Industrial Toxicology Research Centre, M.G.Marg, Lucknow 226001, U.P. India%Inhalation Toxicology Laboratory</pub><pmid>12500662</pmid><tpages>8</tpages></addata></record> |
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| subjects | Administration, Oral Animals Bronchoalveolar Lavage Fluid Disease Models, Animal Enzyme-Linked Immunosorbent Assay Inhalation Exposure Male Mice NAT Oleaceae - chemistry Phytotherapy Plant Extracts - pharmacology Pulmonary Fibrosis - etiology Pulmonary Fibrosis - prevention & control Pulmonary Fibrosis - veterinary Silicon Dioxide - adverse effects Silicosis - prevention & control Silicosis - veterinary 提取物 肺纤维化 |
| title | Silica Induced Early Fibrogenic Reaction in Lung of Mice Ameliorated by Nyctanthes arbortristis Extract |
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