Acute-phase protein synthesis: a key feature of innate immune functions of the liver
The expression of acute-phase proteins (APP’s) maintains homeostasis and tissue repair, but also represents a central component of the organism’s defense strategy, especially in the context of innate immunity. Accordingly, an inflammatory response is accompanied by significant changes in the serum p...
Gespeichert in:
| Veröffentlicht in: | Biological chemistry 2021-08, Vol.402 (9), p.1129-1145 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1145 |
|---|---|
| container_issue | 9 |
| container_start_page | 1129 |
| container_title | Biological chemistry |
| container_volume | 402 |
| creator | Ehlting, Christian Wolf, Stephanie D. Bode, Johannes G. |
| description | The expression of acute-phase proteins (APP’s) maintains homeostasis and tissue repair, but also represents a central component of the organism’s defense strategy, especially in the context of innate immunity. Accordingly, an inflammatory response is accompanied by significant changes in the serum protein composition, an aspect that is also used diagnostically. As the main site of APP synthesis the liver is constantly exposed to antigens or pathogens via blood flow, but also to systemic inflammatory signals originating either from the splanchnic area or from the circulation. Under both homeostatic and acute-phase response (APR) conditions the composition of APP’s is determined by the pattern of regulatory mediators derived from the systemic circulation or from local cell populations, especially liver macrophages. The key regulators mentioned here most frequently are IL-1β, IL-6 and TNF-α. In addition to a variety of molecular mediators described mainly on the basis of
studies, recent data emphasize the
relevance of cellular key effectors as well as molecular key mediators and protein modifications for the regulation and function of APP’s. These are aspects, on which the present review is primarily focused. |
| doi_str_mv | 10.1515/hsz-2021-0209 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_walte</sourceid><recordid>TN_cdi_walterdegruyter_journals_10_1515_hsz_2021_020940291129</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2732546416</sourcerecordid><originalsourceid>FETCH-LOGICAL-c414t-7263ce3cea6510ea36e3fa53f037b815ee111b002214b9499c758dff51569e3</originalsourceid><addsrcrecordid>eNqNkUuLFDEUhYMozji6dCsBN4JEc_OqKsHF0PiCARfOvkhV39gZq1JtHkr7603Z7QjiQgjkQr5zOeeEkMfAX4AG_XKXfjDBBTAueHeHnIOSDVMS9N1fMzDTSH5GHqR0wzlvuZL3yZlUUkglunNyfTmWjGy_swnpPi4ZfaDpEPIOk0-vqKVf8EAd2lwi0sVRH4LNSP08l4DUlTBmv4S0PlUNnfw3jA_JPWenhI9O9wX59PbN9eY9u_r47sPm8oqNClRmjTByxHqs0cDRSoPSWS0dl83QgkYEgIFzIUANneq6sdHt1rka23QoL8iz49Zq-2vBlPvZpxGnyQZcSuqF1ka2muuuok__Qm-WEkP11otGCq2MAlMpdqTGuKQU0fX76GcbDz3wfi27r2X3a9n9Wnbln5y2lmHG7S39u90KtEfgOw6LS6PHMOItVr_DtNVj29YJYOOzXavcLCXkKn3-_9JKvz7RdsoYt_g5lkMd_sT8ZwLFRQdQjf4E5wyt1A</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2732546416</pqid></control><display><type>article</type><title>Acute-phase protein synthesis: a key feature of innate immune functions of the liver</title><source>MEDLINE</source><source>Web of Science - Science Citation Index Expanded - 2021<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" /></source><source>De Gruyter journals</source><creator>Ehlting, Christian ; Wolf, Stephanie D. ; Bode, Johannes G.</creator><creatorcontrib>Ehlting, Christian ; Wolf, Stephanie D. ; Bode, Johannes G.</creatorcontrib><description>The expression of acute-phase proteins (APP’s) maintains homeostasis and tissue repair, but also represents a central component of the organism’s defense strategy, especially in the context of innate immunity. Accordingly, an inflammatory response is accompanied by significant changes in the serum protein composition, an aspect that is also used diagnostically. As the main site of APP synthesis the liver is constantly exposed to antigens or pathogens via blood flow, but also to systemic inflammatory signals originating either from the splanchnic area or from the circulation. Under both homeostatic and acute-phase response (APR) conditions the composition of APP’s is determined by the pattern of regulatory mediators derived from the systemic circulation or from local cell populations, especially liver macrophages. The key regulators mentioned here most frequently are IL-1β, IL-6 and TNF-α. In addition to a variety of molecular mediators described mainly on the basis of
studies, recent data emphasize the
relevance of cellular key effectors as well as molecular key mediators and protein modifications for the regulation and function of APP’s. These are aspects, on which the present review is primarily focused.</description><identifier>ISSN: 1431-6730</identifier><identifier>ISSN: 1437-4315</identifier><identifier>EISSN: 1437-4315</identifier><identifier>DOI: 10.1515/hsz-2021-0209</identifier><identifier>PMID: 34323429</identifier><language>eng</language><publisher>BERLIN: De Gruyter</publisher><subject>Acute phase proteins ; Acute-Phase Proteins - immunology ; Acute-Phase Proteins - metabolism ; acute-phase response ; alpha-1-acid-glycoprotein ; alpha-2-macroglobulin ; Amyloid precursor protein ; Animals ; Antigens ; Biochemistry & Molecular Biology ; Blood flow ; Composition ; hepatocyte ; Hepatocytes ; Homeostasis ; Humans ; IL-1β ; Immunity, Innate ; In vivo methods and tests ; Inflammation ; Inflammatory response ; Innate immunity ; Interleukin 6 ; Life Sciences & Biomedicine ; Liver ; Liver - immunology ; Liver - metabolism ; Macrophages ; Protein biosynthesis ; Protein composition ; Protein synthesis ; Proteins ; Science & Technology ; serum amyloid A ; Serum proteins ; Tumor necrosis factor-α</subject><ispartof>Biological chemistry, 2021-08, Vol.402 (9), p.1129-1145</ispartof><rights>2021 Christian Ehlting et al., published by De Gruyter, Berlin/Boston.</rights><rights>2021. This work is published under http://creativecommons.org/licenses/by/4.0 (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>42</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000685568800011</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c414t-7263ce3cea6510ea36e3fa53f037b815ee111b002214b9499c758dff51569e3</citedby><cites>FETCH-LOGICAL-c414t-7263ce3cea6510ea36e3fa53f037b815ee111b002214b9499c758dff51569e3</cites><orcidid>0000-0003-0103-1856 ; 0000-0002-7141-0694</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.degruyter.com/document/doi/10.1515/hsz-2021-0209/pdf$$EPDF$$P50$$Gwalterdegruyter$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.degruyter.com/document/doi/10.1515/hsz-2021-0209/html$$EHTML$$P50$$Gwalterdegruyter$$Hfree_for_read</linktohtml><link.rule.ids>315,781,785,27929,27930,39263,66759,68543</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34323429$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ehlting, Christian</creatorcontrib><creatorcontrib>Wolf, Stephanie D.</creatorcontrib><creatorcontrib>Bode, Johannes G.</creatorcontrib><title>Acute-phase protein synthesis: a key feature of innate immune functions of the liver</title><title>Biological chemistry</title><addtitle>BIOL CHEM</addtitle><addtitle>Biol Chem</addtitle><description>The expression of acute-phase proteins (APP’s) maintains homeostasis and tissue repair, but also represents a central component of the organism’s defense strategy, especially in the context of innate immunity. Accordingly, an inflammatory response is accompanied by significant changes in the serum protein composition, an aspect that is also used diagnostically. As the main site of APP synthesis the liver is constantly exposed to antigens or pathogens via blood flow, but also to systemic inflammatory signals originating either from the splanchnic area or from the circulation. Under both homeostatic and acute-phase response (APR) conditions the composition of APP’s is determined by the pattern of regulatory mediators derived from the systemic circulation or from local cell populations, especially liver macrophages. The key regulators mentioned here most frequently are IL-1β, IL-6 and TNF-α. In addition to a variety of molecular mediators described mainly on the basis of
studies, recent data emphasize the
relevance of cellular key effectors as well as molecular key mediators and protein modifications for the regulation and function of APP’s. These are aspects, on which the present review is primarily focused.</description><subject>Acute phase proteins</subject><subject>Acute-Phase Proteins - immunology</subject><subject>Acute-Phase Proteins - metabolism</subject><subject>acute-phase response</subject><subject>alpha-1-acid-glycoprotein</subject><subject>alpha-2-macroglobulin</subject><subject>Amyloid precursor protein</subject><subject>Animals</subject><subject>Antigens</subject><subject>Biochemistry & Molecular Biology</subject><subject>Blood flow</subject><subject>Composition</subject><subject>hepatocyte</subject><subject>Hepatocytes</subject><subject>Homeostasis</subject><subject>Humans</subject><subject>IL-1β</subject><subject>Immunity, Innate</subject><subject>In vivo methods and tests</subject><subject>Inflammation</subject><subject>Inflammatory response</subject><subject>Innate immunity</subject><subject>Interleukin 6</subject><subject>Life Sciences & Biomedicine</subject><subject>Liver</subject><subject>Liver - immunology</subject><subject>Liver - metabolism</subject><subject>Macrophages</subject><subject>Protein biosynthesis</subject><subject>Protein composition</subject><subject>Protein synthesis</subject><subject>Proteins</subject><subject>Science & Technology</subject><subject>serum amyloid A</subject><subject>Serum proteins</subject><subject>Tumor necrosis factor-α</subject><issn>1431-6730</issn><issn>1437-4315</issn><issn>1437-4315</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>HGBXW</sourceid><sourceid>EIF</sourceid><recordid>eNqNkUuLFDEUhYMozji6dCsBN4JEc_OqKsHF0PiCARfOvkhV39gZq1JtHkr7603Z7QjiQgjkQr5zOeeEkMfAX4AG_XKXfjDBBTAueHeHnIOSDVMS9N1fMzDTSH5GHqR0wzlvuZL3yZlUUkglunNyfTmWjGy_swnpPi4ZfaDpEPIOk0-vqKVf8EAd2lwi0sVRH4LNSP08l4DUlTBmv4S0PlUNnfw3jA_JPWenhI9O9wX59PbN9eY9u_r47sPm8oqNClRmjTByxHqs0cDRSoPSWS0dl83QgkYEgIFzIUANneq6sdHt1rka23QoL8iz49Zq-2vBlPvZpxGnyQZcSuqF1ka2muuuok__Qm-WEkP11otGCq2MAlMpdqTGuKQU0fX76GcbDz3wfi27r2X3a9n9Wnbln5y2lmHG7S39u90KtEfgOw6LS6PHMOItVr_DtNVj29YJYOOzXavcLCXkKn3-_9JKvz7RdsoYt_g5lkMd_sT8ZwLFRQdQjf4E5wyt1A</recordid><startdate>20210826</startdate><enddate>20210826</enddate><creator>Ehlting, Christian</creator><creator>Wolf, Stephanie D.</creator><creator>Bode, Johannes G.</creator><general>De Gruyter</general><general>Walter De Gruyter</general><general>Walter de Gruyter GmbH</general><scope>BLEPL</scope><scope>DTL</scope><scope>HGBXW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7QP</scope><scope>7QR</scope><scope>7T5</scope><scope>7T7</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-0103-1856</orcidid><orcidid>https://orcid.org/0000-0002-7141-0694</orcidid></search><sort><creationdate>20210826</creationdate><title>Acute-phase protein synthesis: a key feature of innate immune functions of the liver</title><author>Ehlting, Christian ; Wolf, Stephanie D. ; Bode, Johannes G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c414t-7263ce3cea6510ea36e3fa53f037b815ee111b002214b9499c758dff51569e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Acute phase proteins</topic><topic>Acute-Phase Proteins - immunology</topic><topic>Acute-Phase Proteins - metabolism</topic><topic>acute-phase response</topic><topic>alpha-1-acid-glycoprotein</topic><topic>alpha-2-macroglobulin</topic><topic>Amyloid precursor protein</topic><topic>Animals</topic><topic>Antigens</topic><topic>Biochemistry & Molecular Biology</topic><topic>Blood flow</topic><topic>Composition</topic><topic>hepatocyte</topic><topic>Hepatocytes</topic><topic>Homeostasis</topic><topic>Humans</topic><topic>IL-1β</topic><topic>Immunity, Innate</topic><topic>In vivo methods and tests</topic><topic>Inflammation</topic><topic>Inflammatory response</topic><topic>Innate immunity</topic><topic>Interleukin 6</topic><topic>Life Sciences & Biomedicine</topic><topic>Liver</topic><topic>Liver - immunology</topic><topic>Liver - metabolism</topic><topic>Macrophages</topic><topic>Protein biosynthesis</topic><topic>Protein composition</topic><topic>Protein synthesis</topic><topic>Proteins</topic><topic>Science & Technology</topic><topic>serum amyloid A</topic><topic>Serum proteins</topic><topic>Tumor necrosis factor-α</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ehlting, Christian</creatorcontrib><creatorcontrib>Wolf, Stephanie D.</creatorcontrib><creatorcontrib>Bode, Johannes G.</creatorcontrib><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>Web of Science - Science Citation Index Expanded - 2021</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Biological chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ehlting, Christian</au><au>Wolf, Stephanie D.</au><au>Bode, Johannes G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Acute-phase protein synthesis: a key feature of innate immune functions of the liver</atitle><jtitle>Biological chemistry</jtitle><stitle>BIOL CHEM</stitle><addtitle>Biol Chem</addtitle><date>2021-08-26</date><risdate>2021</risdate><volume>402</volume><issue>9</issue><spage>1129</spage><epage>1145</epage><pages>1129-1145</pages><issn>1431-6730</issn><issn>1437-4315</issn><eissn>1437-4315</eissn><abstract>The expression of acute-phase proteins (APP’s) maintains homeostasis and tissue repair, but also represents a central component of the organism’s defense strategy, especially in the context of innate immunity. Accordingly, an inflammatory response is accompanied by significant changes in the serum protein composition, an aspect that is also used diagnostically. As the main site of APP synthesis the liver is constantly exposed to antigens or pathogens via blood flow, but also to systemic inflammatory signals originating either from the splanchnic area or from the circulation. Under both homeostatic and acute-phase response (APR) conditions the composition of APP’s is determined by the pattern of regulatory mediators derived from the systemic circulation or from local cell populations, especially liver macrophages. The key regulators mentioned here most frequently are IL-1β, IL-6 and TNF-α. In addition to a variety of molecular mediators described mainly on the basis of
studies, recent data emphasize the
relevance of cellular key effectors as well as molecular key mediators and protein modifications for the regulation and function of APP’s. These are aspects, on which the present review is primarily focused.</abstract><cop>BERLIN</cop><pub>De Gruyter</pub><pmid>34323429</pmid><doi>10.1515/hsz-2021-0209</doi><tpages>017</tpages><orcidid>https://orcid.org/0000-0003-0103-1856</orcidid><orcidid>https://orcid.org/0000-0002-7141-0694</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1431-6730 |
| ispartof | Biological chemistry, 2021-08, Vol.402 (9), p.1129-1145 |
| issn | 1431-6730 1437-4315 1437-4315 |
| language | eng |
| recordid | cdi_walterdegruyter_journals_10_1515_hsz_2021_020940291129 |
| source | MEDLINE; Web of Science - Science Citation Index Expanded - 2021<img src="https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg" />; De Gruyter journals |
| subjects | Acute phase proteins Acute-Phase Proteins - immunology Acute-Phase Proteins - metabolism acute-phase response alpha-1-acid-glycoprotein alpha-2-macroglobulin Amyloid precursor protein Animals Antigens Biochemistry & Molecular Biology Blood flow Composition hepatocyte Hepatocytes Homeostasis Humans IL-1β Immunity, Innate In vivo methods and tests Inflammation Inflammatory response Innate immunity Interleukin 6 Life Sciences & Biomedicine Liver Liver - immunology Liver - metabolism Macrophages Protein biosynthesis Protein composition Protein synthesis Proteins Science & Technology serum amyloid A Serum proteins Tumor necrosis factor-α |
| title | Acute-phase protein synthesis: a key feature of innate immune functions of the liver |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-11T13%3A15%3A04IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_walte&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Acute-phase%20protein%20synthesis:%20a%20key%20feature%20of%20innate%20immune%20functions%20of%20the%20liver&rft.jtitle=Biological%20chemistry&rft.au=Ehlting,%20Christian&rft.date=2021-08-26&rft.volume=402&rft.issue=9&rft.spage=1129&rft.epage=1145&rft.pages=1129-1145&rft.issn=1431-6730&rft.eissn=1437-4315&rft_id=info:doi/10.1515/hsz-2021-0209&rft_dat=%3Cproquest_walte%3E2732546416%3C/proquest_walte%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2732546416&rft_id=info:pmid/34323429&rfr_iscdi=true |