Oligonucleotide compositions and methods of making the same

The present disclosure provides a solid phase method of making oligonucleotides via sequential coupling cycles including at least one coupling of a dinucleotide dimer subunit to a free 3′-terminal group of a growing chain. The oligonucleotides include at least two nucleoside subunits joined by a N3′...

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1. Verfasser: Geron Corporation
Format: Patent
Sprache:eng
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