Methods of treating disease by metabolic control of T-cell differentiation

HHProvided herein are methods for treating an individual for a disease (e.g., an autoimmune disease or a cancer) using an active agent which affects metabolism of α-ketoglutarate (α-KG) and/or 2-hydroxyglutarate (2-HG) in differentiating T cells. In some embodiments, a Got1 inhibitor is used to gene...

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1. Verfasser:	The J. David Gladstone Institutes, a testamentary trust established under the Will of J. David Gladstone
Format:	Patent
Sprache:	eng
Online-Zugang:	Volltext bestellen
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