Prostacyclin directed differentiation of cardiomyocytes from human embryonic stem cells

Prostacyclin directed differentiation of cardiomyocytes from human embryonic stem cells

The present invention relates to the induction of differentiation in stem cells to cardiomyocytes and factors such as prostaglandin alone or in combination with other factors including essential minerals selected from the group including transferrin and selenium, small molecules selected from the gr...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Davidson, Bruce Paul, Graichen, Ralph Eberhard, Zweigerdt, Robert, Xu, Xiuqin, Mummery, Christine Lindsay, Sun, William
Format: Patent
Sprache:eng
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page
container_issue
container_start_page
container_title
container_volume
creator Davidson, Bruce Paul
Graichen, Ralph Eberhard
Zweigerdt, Robert
Xu, Xiuqin
Mummery, Christine Lindsay
Sun, William
description The present invention relates to the induction of differentiation in stem cells to cardiomyocytes and factors such as prostaglandin alone or in combination with other factors including essential minerals selected from the group including transferrin and selenium, small molecules selected from the group including a p38 MAPK inhibitor such as SB203580 and protein growth factors of the FGF, IGF and BMP families such as but not limited to IGF1, FGF2, BMP2, BMP4 and BMP6. and insulin that influence the process of differentiation to cardiomyocytes. Media that is appropriate for the induction of differentiation of cardiomyocytes from stem cells is also provided wherein the media contains these factors. The use of cardiomyocytes and cardiac progenitors produced by the directed differentiation in transplantation and screening for cardiac compounds is also provided.
format Patent
fullrecord <record><control><sourceid>uspatents_EFH</sourceid><recordid>TN_cdi_uspatents_grants_08318489</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>08318489</sourcerecordid><originalsourceid>FETCH-uspatents_grants_083184893</originalsourceid><addsrcrecordid>eNqNjDEKAkEMAK-xEPUP-YCgnMVZi2JpIVhKzGZ1YXcjSa7Y33uCD7CaKYaZd7eLijlSo5wqhKRMzmGSGFm5ekJPUkEiEGpIUppQczaIKgVeY8EKXB7apCYCcy5AnLMtu1nEbLz6cdHB6Xg9nNejvdGnsd2fil9shn477IZ9_0fyAbCCO_0</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>Prostacyclin directed differentiation of cardiomyocytes from human embryonic stem cells</title><source>USPTO Issued Patents</source><creator>Davidson, Bruce Paul ; Graichen, Ralph Eberhard ; Zweigerdt, Robert ; Xu, Xiuqin ; Mummery, Christine Lindsay ; Sun, William</creator><creatorcontrib>Davidson, Bruce Paul ; Graichen, Ralph Eberhard ; Zweigerdt, Robert ; Xu, Xiuqin ; Mummery, Christine Lindsay ; Sun, William</creatorcontrib><description>The present invention relates to the induction of differentiation in stem cells to cardiomyocytes and factors such as prostaglandin alone or in combination with other factors including essential minerals selected from the group including transferrin and selenium, small molecules selected from the group including a p38 MAPK inhibitor such as SB203580 and protein growth factors of the FGF, IGF and BMP families such as but not limited to IGF1, FGF2, BMP2, BMP4 and BMP6. and insulin that influence the process of differentiation to cardiomyocytes. Media that is appropriate for the induction of differentiation of cardiomyocytes from stem cells is also provided wherein the media contains these factors. The use of cardiomyocytes and cardiac progenitors produced by the directed differentiation in transplantation and screening for cardiac compounds is also provided.</description><language>eng</language><creationdate>2012</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/8318489$$EPDF$$P50$$Guspatents$$Hfree_for_read</linktopdf><link.rule.ids>230,308,776,798,881,64012</link.rule.ids><linktorsrc>$$Uhttps://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/8318489$$EView_record_in_USPTO$$FView_record_in_$$GUSPTO$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>Davidson, Bruce Paul</creatorcontrib><creatorcontrib>Graichen, Ralph Eberhard</creatorcontrib><creatorcontrib>Zweigerdt, Robert</creatorcontrib><creatorcontrib>Xu, Xiuqin</creatorcontrib><creatorcontrib>Mummery, Christine Lindsay</creatorcontrib><creatorcontrib>Sun, William</creatorcontrib><title>Prostacyclin directed differentiation of cardiomyocytes from human embryonic stem cells</title><description>The present invention relates to the induction of differentiation in stem cells to cardiomyocytes and factors such as prostaglandin alone or in combination with other factors including essential minerals selected from the group including transferrin and selenium, small molecules selected from the group including a p38 MAPK inhibitor such as SB203580 and protein growth factors of the FGF, IGF and BMP families such as but not limited to IGF1, FGF2, BMP2, BMP4 and BMP6. and insulin that influence the process of differentiation to cardiomyocytes. Media that is appropriate for the induction of differentiation of cardiomyocytes from stem cells is also provided wherein the media contains these factors. The use of cardiomyocytes and cardiac progenitors produced by the directed differentiation in transplantation and screening for cardiac compounds is also provided.</description><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2012</creationdate><recordtype>patent</recordtype><sourceid>EFH</sourceid><recordid>eNqNjDEKAkEMAK-xEPUP-YCgnMVZi2JpIVhKzGZ1YXcjSa7Y33uCD7CaKYaZd7eLijlSo5wqhKRMzmGSGFm5ekJPUkEiEGpIUppQczaIKgVeY8EKXB7apCYCcy5AnLMtu1nEbLz6cdHB6Xg9nNejvdGnsd2fil9shn477IZ9_0fyAbCCO_0</recordid><startdate>20121127</startdate><enddate>20121127</enddate><creator>Davidson, Bruce Paul</creator><creator>Graichen, Ralph Eberhard</creator><creator>Zweigerdt, Robert</creator><creator>Xu, Xiuqin</creator><creator>Mummery, Christine Lindsay</creator><creator>Sun, William</creator><scope>EFH</scope></search><sort><creationdate>20121127</creationdate><title>Prostacyclin directed differentiation of cardiomyocytes from human embryonic stem cells</title><author>Davidson, Bruce Paul ; Graichen, Ralph Eberhard ; Zweigerdt, Robert ; Xu, Xiuqin ; Mummery, Christine Lindsay ; Sun, William</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-uspatents_grants_083184893</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>2012</creationdate><toplevel>online_resources</toplevel><creatorcontrib>Davidson, Bruce Paul</creatorcontrib><creatorcontrib>Graichen, Ralph Eberhard</creatorcontrib><creatorcontrib>Zweigerdt, Robert</creatorcontrib><creatorcontrib>Xu, Xiuqin</creatorcontrib><creatorcontrib>Mummery, Christine Lindsay</creatorcontrib><creatorcontrib>Sun, William</creatorcontrib><collection>USPTO Issued Patents</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Davidson, Bruce Paul</au><au>Graichen, Ralph Eberhard</au><au>Zweigerdt, Robert</au><au>Xu, Xiuqin</au><au>Mummery, Christine Lindsay</au><au>Sun, William</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Prostacyclin directed differentiation of cardiomyocytes from human embryonic stem cells</title><date>2012-11-27</date><risdate>2012</risdate><abstract>The present invention relates to the induction of differentiation in stem cells to cardiomyocytes and factors such as prostaglandin alone or in combination with other factors including essential minerals selected from the group including transferrin and selenium, small molecules selected from the group including a p38 MAPK inhibitor such as SB203580 and protein growth factors of the FGF, IGF and BMP families such as but not limited to IGF1, FGF2, BMP2, BMP4 and BMP6. and insulin that influence the process of differentiation to cardiomyocytes. Media that is appropriate for the induction of differentiation of cardiomyocytes from stem cells is also provided wherein the media contains these factors. The use of cardiomyocytes and cardiac progenitors produced by the directed differentiation in transplantation and screening for cardiac compounds is also provided.</abstract><oa>free_for_read</oa></addata></record>
fulltext fulltext_linktorsrc
identifier
ispartof
issn
language eng
recordid cdi_uspatents_grants_08318489
source USPTO Issued Patents
title Prostacyclin directed differentiation of cardiomyocytes from human embryonic stem cells
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-29T06%3A12%3A25IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-uspatents_EFH&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=Davidson,%20Bruce%20Paul&rft.date=2012-11-27&rft_id=info:doi/&rft_dat=%3Cuspatents_EFH%3E08318489%3C/uspatents_EFH%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true