Immunoassays exhibiting reduced cross-reactivity with hydrophobic drug analyte metabolites

The present disclosure provides among other things immunoassays exhibiting reduced cross-reactivity with analyte metabolites. Additionally, the present disclosure provides diagnostic immunoassays to determine the concentration or level in a test sample of a hydrophobic drug that metabolizes in vivo...

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Hauptverfasser:	Brate, Elaine M, Finley, David M, Holets-McCormack, Shelley R, Pacenti, David P, Piktel, Ryan E, Shields, Michelle L, Spring, Thomas G, Wang, Phillip P
Format:	Patent
Sprache:	eng
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creator	Brate, Elaine M Finley, David M Holets-McCormack, Shelley R Pacenti, David P Piktel, Ryan E Shields, Michelle L Spring, Thomas G Wang, Phillip P
description	The present disclosure provides among other things immunoassays exhibiting reduced cross-reactivity with analyte metabolites. Additionally, the present disclosure provides diagnostic immunoassays to determine the concentration or level in a test sample of a hydrophobic drug that metabolizes in vivo or in vitro to form cross-reacting metabolites wherein cross-reactivity with such metabolites of the drug analyte is reduced. In particular, the disclosure provides such immunoassays where the hydrophobic drug is an immunosuppressant drug such as cyclosporine A.
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title	Immunoassays exhibiting reduced cross-reactivity with hydrophobic drug analyte metabolites
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