Method for producing microspheres loaded with drugs and microspheres loaded with drugs produced thereby
The present invention relates to a method for producing polymeric microspheres loaded with drugs and polymeric microspheres loaded with drugs produced thereby, specifically a method for producing polymeric microspheres loaded with drugs, the method comprising the steps of a) adding a dispersion phas...
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| creator | Sah, Hong Kee |
| description | The present invention relates to a method for producing polymeric microspheres loaded with drugs and polymeric microspheres loaded with drugs produced thereby, specifically a method for producing polymeric microspheres loaded with drugs, the method comprising the steps of a) adding a dispersion phase containing a high molecular compound, a drug, and a water-insoluble organic solvent to a dispersion solvent to produce an O/W (oil-in-water) type or O/O (oil-in-oil) type emulsion, or adding a W/O (water-in-oil) type emulsion, which is prepared by emulsifying an aqueous solution, in which a drug is dissolved, in a water-insoluble organic solvent, in which the high molecular compound is dissolved, to the dispersion solvent to produce a W/O/W (water-in-oil-in-water) type emulsion; and b) adding an ammonia solution to the emulsion produced in step a) to convert the water-insoluble organic solvent into water-soluble solvents, and polymeric microspheres loaded with drugs produced thereby. According to the present invention, the desired polymeric microspheres loaded with drugs can be simply produced with a small amount of water in a short period of time. |
| format | Patent |
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According to the present invention, the desired polymeric microspheres loaded with drugs can be simply produced with a small amount of water in a short period of time.</description><language>eng</language><creationdate>2012</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/8202524$$EPDF$$P50$$Guspatents$$Hfree_for_read</linktopdf><link.rule.ids>230,309,781,803,886,64044</link.rule.ids><linktorsrc>$$Uhttps://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/8202524$$EView_record_in_USPTO$$FView_record_in_$$GUSPTO$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>Sah, Hong Kee</creatorcontrib><creatorcontrib>SK Chemicals Co., Ltd</creatorcontrib><creatorcontrib>EWHA University-Industry Collaboration Foundation</creatorcontrib><title>Method for producing microspheres loaded with drugs and microspheres loaded with drugs produced thereby</title><description>The present invention relates to a method for producing polymeric microspheres loaded with drugs and polymeric microspheres loaded with drugs produced thereby, specifically a method for producing polymeric microspheres loaded with drugs, the method comprising the steps of a) adding a dispersion phase containing a high molecular compound, a drug, and a water-insoluble organic solvent to a dispersion solvent to produce an O/W (oil-in-water) type or O/O (oil-in-oil) type emulsion, or adding a W/O (water-in-oil) type emulsion, which is prepared by emulsifying an aqueous solution, in which a drug is dissolved, in a water-insoluble organic solvent, in which the high molecular compound is dissolved, to the dispersion solvent to produce a W/O/W (water-in-oil-in-water) type emulsion; and b) adding an ammonia solution to the emulsion produced in step a) to convert the water-insoluble organic solvent into water-soluble solvents, and polymeric microspheres loaded with drugs produced thereby. According to the present invention, the desired polymeric microspheres loaded with drugs can be simply produced with a small amount of water in a short period of time.</description><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2012</creationdate><recordtype>patent</recordtype><sourceid>EFH</sourceid><recordid>eNrjZEj3TS3JyE9RSMsvUigoyk8pTc7MS1fIzUwuyi8uyEgtSi1WyMlPTElNUSjPLMlQSCkqTS9WSMxLIaQEYhZQrASkIqmSh4E1LTGnOJUXSnMzKLi5hjh76JYWFySWpOaVFMenFyWCKAMLIwMjUyMTYyKUAAC8NEF1</recordid><startdate>20120619</startdate><enddate>20120619</enddate><creator>Sah, Hong Kee</creator><scope>EFH</scope></search><sort><creationdate>20120619</creationdate><title>Method for producing microspheres loaded with drugs and microspheres loaded with drugs produced thereby</title><author>Sah, Hong Kee</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-uspatents_grants_082025243</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>2012</creationdate><toplevel>online_resources</toplevel><creatorcontrib>Sah, Hong Kee</creatorcontrib><creatorcontrib>SK Chemicals Co., Ltd</creatorcontrib><creatorcontrib>EWHA University-Industry Collaboration Foundation</creatorcontrib><collection>USPTO Issued Patents</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Sah, Hong Kee</au><aucorp>SK Chemicals Co., Ltd</aucorp><aucorp>EWHA University-Industry Collaboration Foundation</aucorp><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Method for producing microspheres loaded with drugs and microspheres loaded with drugs produced thereby</title><date>2012-06-19</date><risdate>2012</risdate><abstract>The present invention relates to a method for producing polymeric microspheres loaded with drugs and polymeric microspheres loaded with drugs produced thereby, specifically a method for producing polymeric microspheres loaded with drugs, the method comprising the steps of a) adding a dispersion phase containing a high molecular compound, a drug, and a water-insoluble organic solvent to a dispersion solvent to produce an O/W (oil-in-water) type or O/O (oil-in-oil) type emulsion, or adding a W/O (water-in-oil) type emulsion, which is prepared by emulsifying an aqueous solution, in which a drug is dissolved, in a water-insoluble organic solvent, in which the high molecular compound is dissolved, to the dispersion solvent to produce a W/O/W (water-in-oil-in-water) type emulsion; and b) adding an ammonia solution to the emulsion produced in step a) to convert the water-insoluble organic solvent into water-soluble solvents, and polymeric microspheres loaded with drugs produced thereby. According to the present invention, the desired polymeric microspheres loaded with drugs can be simply produced with a small amount of water in a short period of time.</abstract><oa>free_for_read</oa></addata></record> |
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| title | Method for producing microspheres loaded with drugs and microspheres loaded with drugs produced thereby |
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