Tetrahydro-naphthalene derivatives

Tetrahydro-naphthalene derivatives

This invention relates to tetrahydro-naphthalene derivatives and salts thereof which are useful as an active ingredient of pharmaceutical preparations. The tetrahydro-naphthalene derivatives of the present invention have excellent activity as VR1 antagonist and useful for the prophylaxis and treatme...

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Hauptverfasser: Tajimi, Masaomi, Kokubo, Toshio, Shiroo, Masahiro, Tsukimi, Yasuhiro, Yura, Takeshi, Urbahns, Klaus, Yamamoto, Noriyuki, Mogi, Muneto, Fujishima, Hiroshi, Masuda, Tsutomu, Yoshida, Nagahiro, Moriwaki, Toshiya
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creator Tajimi, Masaomi
Kokubo, Toshio
Shiroo, Masahiro
Tsukimi, Yasuhiro
Yura, Takeshi
Urbahns, Klaus
Yamamoto, Noriyuki
Mogi, Muneto
Fujishima, Hiroshi
Masuda, Tsutomu
Yoshida, Nagahiro
Moriwaki, Toshiya
description This invention relates to tetrahydro-naphthalene derivatives and salts thereof which are useful as an active ingredient of pharmaceutical preparations. The tetrahydro-naphthalene derivatives of the present invention have excellent activity as VR1 antagonist and useful for the prophylaxis and treatment of diseases associated with VR1 activity, in particular for the treatment of urinary incontinence, overactive bladder, urge urinary incontinence, chronic pain, neuropathic pain, post-operative pain, rheumatoid arthritic pain, neuralgia, neuropathies, algesia, nerve injury, ischaemia, neurodegeneration, stroke, inflammatory disorders, asthma and COPD.
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title Tetrahydro-naphthalene derivatives
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