Inhibitors of 11-beta-hydroxysteroid dehydrogenase 1

Inhibitors of 11-beta-hydroxysteroid dehydrogenase 1

The present invention discloses novel compounds of Formula I: (I) having 11-HSD type 1 antagonist activity, as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula I, as well as methods of using the c...

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Hauptverfasser: Bush, Julie Kay, Hansen, Marvin Martin, Li, Renhua, Mabry, Thomas Edward, Snyder, Nancy June, Wallace, Owen Brendan, Xu, Yanping
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Sprache:eng
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creator Bush, Julie Kay
Hansen, Marvin Martin
Li, Renhua
Mabry, Thomas Edward
Snyder, Nancy June
Wallace, Owen Brendan
Xu, Yanping
description The present invention discloses novel compounds of Formula I: (I) having 11-HSD type 1 antagonist activity, as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula I, as well as methods of using the compounds and compositions to treat diabetes, hyperglycemia, obesity, hypertension, hyperlipidemia, metabolic syndrome, and other conditions associated with 11-HSD type 1 activity.
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title Inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
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