Piperidine derivative or salt thereof

Piperidine derivative or salt thereof

To provide a compound which can be used for treating diseases in which a calcium sensing receptor (CaSR) participates, particularly hyperparathyroidism. It was found that a novel piperidine derivative which is characterized in that one of a 3-position and a 4-position is substituted with an aminomet...

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Hauptverfasser: Hachiya, Shunichiro, Ikegai, Kazuhiro, Ibuka, Ryotaro, Takahashi, Taisuke, Oku, Makoto, Seo, Ryushi, Terada, Yoh, Sanagi, Masanao
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Sprache:eng
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creator Hachiya, Shunichiro
Ikegai, Kazuhiro
Ibuka, Ryotaro
Takahashi, Taisuke
Oku, Makoto
Seo, Ryushi
Terada, Yoh
Sanagi, Masanao
description To provide a compound which can be used for treating diseases in which a calcium sensing receptor (CaSR) participates, particularly hyperparathyroidism. It was found that a novel piperidine derivative which is characterized in that one of a 3-position and a 4-position is substituted with an aminomethyl group substituted with an arylalkyl group or the like and the other position is substituted with aryl, heteroaryl or the like, or a salt thereof, has an excellent CaSR agonistic regulatory action, and also has excellent selectivity with a CYP2D6 inhibitory action having a possibility of causing drug interaction. Based on the above, this novel piperidine derivative is useful as a therapeutic agent for diseases in which CaSR participates (hyperparathyroidism, renal osteodystrophy, hypercalcemia, and the like).
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title Piperidine derivative or salt thereof
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