Tricyclic 1,2,4-triazine oxides and compositions for therapeutic use in cancer treatments

Tricyclic 1,2,4-triazine oxides and compositions for therapeutic use in cancer treatments

The invention relates to novel tricyclic 1,2,4-triazine-1-oxides and novel tricyclic 1,2,4-triazine-1,4-dioxides of formula I and to related analogues, to their preparation, and to their use as hypoxia-selective drugs and radiosensitizers for cancer therapy, both alone or in combination with radiati...

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Hauptverfasser: Hay, Michael Patrick, Blaser, Adrian, Denny, William Alexander, Hicks, Kevin Owen, Lee, Ho Huat, Pchalek, Karin, Pruijn, Frederik Bastiaan, Siim, Bronwyn Gae, Wilson, William Robert, Yang, Shangjin
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creator Hay, Michael Patrick
Blaser, Adrian
Denny, William Alexander
Hicks, Kevin Owen
Lee, Ho Huat
Pchalek, Karin
Pruijn, Frederik Bastiaan
Siim, Bronwyn Gae
Wilson, William Robert
Yang, Shangjin
description The invention relates to novel tricyclic 1,2,4-triazine-1-oxides and novel tricyclic 1,2,4-triazine-1,4-dioxides of formula I and to related analogues, to their preparation, and to their use as hypoxia-selective drugs and radiosensitizers for cancer therapy, both alone or in combination with radiation and/or other anticancer drugs.
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title Tricyclic 1,2,4-triazine oxides and compositions for therapeutic use in cancer treatments
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