Selection of intracellular immunoglobulins

A general immunoglobulin-target assay system is provided, in which a positive outcome (the generation of a signal) depends only on the intracellular interaction of immunoglobulin with target. This can be accomplished for many immunoglobulins expressed in yeast and/or in mammalian cells and allows th...

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Bibliographische Detailangaben
Hauptverfasser: Tse, Wai-Choi Eric, Rabbits, Terence, Cattaneo, Antonino, Visintin, Michela
Format: Patent
Sprache:eng
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Zusammenfassung:A general immunoglobulin-target assay system is provided, in which a positive outcome (the generation of a signal) depends only on the intracellular interaction of immunoglobulin with target. This can be accomplished for many immunoglobulins expressed in yeast and/or in mammalian cells and allows the selection of immunoglobulins which are capable of functioning in an intracellular environment.