Broadspectrum 2-amino-benzoxazole sulfonamide HIV protease inhibitors
1 8 1-62-63-7121 11a11b10a10b92 1-681-681-622823 1-63-73-71-41-44 1-41-43-72-62-61-65 6 1-6The present invention concerns the compounds having the formula N-oxides, salts, stereoisomeric forms, racemic mixtures, prodrugs, esters and metabolites thereof, wherein Rand Reach are H, optionally substitut...
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| creator | Surleraux, Dominique Louis Nestor Ghislain Vendeville, Sandrine Marie Helene Verschueren, Wim Gaston De Bethune, Marie-Pierre T. M. M. G De Kock, Herman Augustinus Tahri, Abdellah |
| description | 1 8 1-62-63-7121 11a11b10a10b92 1-681-681-622823 1-63-73-71-41-44 1-41-43-72-62-61-65 6 1-6The present invention concerns the compounds having the formula N-oxides, salts, stereoisomeric forms, racemic mixtures, prodrugs, esters and metabolites thereof, wherein Rand Reach are H, optionally substituted Calkyl, Calkenyl, Ccycloalkyl, aryl, Het, Het; Rmay also be a radical of formula (RR)NC(RR)CR-; t is 0, 1 or 2; Ris H or Calkyl; L is -C(═O)-, -O-C(═O)-, -NR-C(═O)-, -O-Calkanediyl-C(═O)-, -NR-Calkanediyl-C(═O)-, -S(═O)-, -O-S(═O)-, -NR-S(═O); Ris Calkyl, aryl, Ccycloalkyl, CcycloalkylCalkyl, or arylCalkyl; Ris H, CalkylOC(═O), carboxyl, aminoC(═O), mono- or di(Calkyl)aminoC(═O), Ccycloalkyl, Calkenyl, Calkynyl or optionally substituted Calkyl; Rand Rare H or Calkyl. It further relates to their use as broadspectrum HIV protease inhibitors, processes for their preparation as well as pharmaceutical compositions and diagnostic kits comprising them. It also concerns combinations thereof with another anti-retroviral agent, and to their use in assays as reference compounds or as reagents. |
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G ; De Kock, Herman Augustinus ; Tahri, Abdellah</creator><creatorcontrib>Surleraux, Dominique Louis Nestor Ghislain ; Vendeville, Sandrine Marie Helene ; Verschueren, Wim Gaston ; De Bethune, Marie-Pierre T. M. M. G ; De Kock, Herman Augustinus ; Tahri, Abdellah ; Tibotec Pharmaceuticals Ltd</creatorcontrib><description>1 8 1-62-63-7121 11a11b10a10b92 1-681-681-622823 1-63-73-71-41-44 1-41-43-72-62-61-65 6 1-6The present invention concerns the compounds having the formula N-oxides, salts, stereoisomeric forms, racemic mixtures, prodrugs, esters and metabolites thereof, wherein Rand Reach are H, optionally substituted Calkyl, Calkenyl, Ccycloalkyl, aryl, Het, Het; Rmay also be a radical of formula (RR)NC(RR)CR-; t is 0, 1 or 2; Ris H or Calkyl; L is -C(═O)-, -O-C(═O)-, -NR-C(═O)-, -O-Calkanediyl-C(═O)-, -NR-Calkanediyl-C(═O)-, -S(═O)-, -O-S(═O)-, -NR-S(═O); Ris Calkyl, aryl, Ccycloalkyl, CcycloalkylCalkyl, or arylCalkyl; Ris H, CalkylOC(═O), carboxyl, aminoC(═O), mono- or di(Calkyl)aminoC(═O), Ccycloalkyl, Calkenyl, Calkynyl or optionally substituted Calkyl; Rand Rare H or Calkyl. 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It further relates to their use as broadspectrum HIV protease inhibitors, processes for their preparation as well as pharmaceutical compositions and diagnostic kits comprising them. It also concerns combinations thereof with another anti-retroviral agent, and to their use in assays as reference compounds or as reagents.</abstract><oa>free_for_read</oa></addata></record> |
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| title | Broadspectrum 2-amino-benzoxazole sulfonamide HIV protease inhibitors |
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