Conjugates of hydroxyalkyl starch and an active agent

Conjugates of hydroxyalkyl starch and an active agent

The invention relates to compounds, comprising a conjugate of hydroxyalkyl starch (HAS) and an active agent, whereby the hydroxyalkyl starch is either directly covalently bonded to the active agent, or by means of a linker. The invention further relates to methods for the production of a covalent HA...

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Hauptverfasser: Sommermeyer, Klaus, Eichner, Wolfram, Frie, Sven, Jungheinrich, Cornelius, Scharpf, Roland, Lutterbeck, Katharina, Hemberger, Jurgen, Orlando, Michele
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Sprache:eng
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creator Sommermeyer, Klaus
Eichner, Wolfram
Frie, Sven
Jungheinrich, Cornelius
Scharpf, Roland
Lutterbeck, Katharina
Hemberger, Jurgen
Orlando, Michele
description The invention relates to compounds, comprising a conjugate of hydroxyalkyl starch (HAS) and an active agent, whereby the hydroxyalkyl starch is either directly covalently bonded to the active agent, or by means of a linker. The invention further relates to methods for the production of a covalent HAS-active agent conjugate, whereby HAS and an active agent are reacted in a reaction medium, characterised in that the reaction medium is water or a mixture of water and an organic solvent, comprising at least 10 wt. % water.
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title Conjugates of hydroxyalkyl starch and an active agent
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