Stabilized aptamers to PSMA and their use as prostate cancer therapeutics

The present invention provides stabilized, high affinity nucleic acid ligands to PSMA. Methods for the identification and preparation of novel, stable, high affinity ligands to PSMA using the SELEX™ method with 2′-O-methyl substituted nucleic acids, and cell surface SELEX™ are described herein. Also...

Ausführliche Beschreibung

Bibliographische Detailangaben

Hauptverfasser:	Diener, John L, Hatala, Paul, Wagner-Whyte, Jess, Wilson, Charles
Format:	Patent
Sprache:	eng
Online-Zugang:	Volltext bestellen
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