Crystalline polymorphs of methanesulfonic acid addition salts of Imatinib
This invention relates to the methanesulfonic acid addition salts of Imatinib and to the synthesis thereof. In particular, this invention relates to the synthesis of crystalline α-form of Imatinib methanesulfonate. Furthermore, the invention is directed to a novel acid addition salt of 4-(4-methylpi...
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| creator | Szczepek, Wojciech Samson-Lazinska, Dorota Zagrodzki, Bogdan Glice, Magdalena Maruszak, Wioleta Korczak, Katarzyna Modzelewski, Ryszard Lawecka, Marta Kaczmarek, Lukasz Szelejewski, Wieslaw Fraczek, Urszula Cmoch, Piotr |
| description | This invention relates to the methanesulfonic acid addition salts of Imatinib and to the synthesis thereof. In particular, this invention relates to the synthesis of crystalline α-form of Imatinib methanesulfonate. Furthermore, the invention is directed to a novel acid addition salt of 4-(4-methylpiperazin-1-ylmethyl)-N-[4-methyl-3-[(4-pyridin-3-yl)pyrimidin-2-ylamino)phenyl]benzamide with two molecules of methanesulfonic acid and to the polymorphic forms thereof, as well as to their pharmaceutical compositions. |
| format | Patent |
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| title | Crystalline polymorphs of methanesulfonic acid addition salts of Imatinib |
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