Cycloalkyl lactam derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1

Cycloalkyl lactam derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1

The present invention discloses compounds of Formula I: (I) having 11beta-HSD type 1 antagonist activity, as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula I, as well as the use of the Formula I...

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Hauptverfasser: Aicher, Thomas Daniel, Chicarelli, Mark Joseph, Hinklin, Ronald Jay, Tian, Hongqi, Wallace, Owen Brendan, Allen, John Gordon, Chen, Zhaogen, Mabry, Thomas Edward, McCowan, Jefferson Ray, Snyder, Nancy June, Winneroski, Jr, Leonard Larry
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creator Aicher, Thomas Daniel
Chicarelli, Mark Joseph
Hinklin, Ronald Jay
Tian, Hongqi
Wallace, Owen Brendan
Allen, John Gordon
Chen, Zhaogen
Mabry, Thomas Edward
McCowan, Jefferson Ray
Snyder, Nancy June
Winneroski, Jr, Leonard Larry
description The present invention discloses compounds of Formula I: (I) having 11beta-HSD type 1 antagonist activity, as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula I, as well as the use of the Formula I and compositions as medicaments to treat diabetes, hyperglycemia, obesity, hypertension, hyperlipidemia, Syndrome X, and other conditions associated with hyperglycemia.
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title Cycloalkyl lactam derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
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