Process for preparation of pharmaceutically pure anhydrous calcipotriol

A process for the preparation of a pharmaceutical-grade anhydrous calcipotriol comprising: (a) dissolving crude calcipotriol having a water content of X% by weight in a first solvent or in a mixture of two or more first solvents, said first solvent or said mixture of two or more first solvents formi...

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Hauptverfasser:	Kutner, Andrzej, Chodyński, Michal, Ryznar, Teresa, Fitak, Hanna, Winiarski, Jerzy, Górecki, Bartlomiej, Burzyńska, Agnieszka, Szelejewski, Wieslaw
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creator	Kutner, Andrzej Chodyński, Michal Ryznar, Teresa Fitak, Hanna Winiarski, Jerzy Górecki, Bartlomiej Burzyńska, Agnieszka Szelejewski, Wieslaw
description	A process for the preparation of a pharmaceutical-grade anhydrous calcipotriol comprising: (a) dissolving crude calcipotriol having a water content of X% by weight in a first solvent or in a mixture of two or more first solvents, said first solvent or said mixture of two or more first solvents forming an azeotropic system with water, to obtain a solution of crude calcipotriol; (b) obtaining an intermediate calcipotriol by (i) placing said solution of crude calcipotriol under a reduced pressure and evaporating, if X is greater than or equal to 1, or (ii) crystallizing, if X is lower than 1; and (c) re-dissolving said intermediate calcipotriol in a second solvent or a mixture of two or more second solvents, said second solvent being anhydrous, and crystallizing at least once to obtain pharmaceutical-grade anhydrous calcipotriol.
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title	Process for preparation of pharmaceutically pure anhydrous calcipotriol
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