Process for lactonization in the preparation of statins

Process for lactonization in the preparation of statins

The present invention relates to an improved and industrial friendly process for lactonization to produce compound of the Formula [I], from compound of the Formula [II] in presence of an inorganic compound as a suitable lactonizing agent, preferably alkali metal hydrogen sulfate, and crystallizing t...

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Hauptverfasser: Singh, Govind, Bhadwal, Paramvir, Jaiswal, Sanjay, Panchasara, Dinesh R, Thaper, Rajesh Kumar, Dubey, Sushil Kumar, Khanna, Jag Mohan
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Sprache:eng
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creator Singh, Govind
Bhadwal, Paramvir
Jaiswal, Sanjay
Panchasara, Dinesh R
Thaper, Rajesh Kumar
Dubey, Sushil Kumar
Khanna, Jag Mohan
description The present invention relates to an improved and industrial friendly process for lactonization to produce compound of the Formula [I], from compound of the Formula [II] in presence of an inorganic compound as a suitable lactonizing agent, preferably alkali metal hydrogen sulfate, and crystallizing the obtained lactone product in a solvent; or treating compound of the Formula [II] in the presence of an inorganic compound preferably alkali metal hydrogen sulfate using phase transfer catalyst in heterogeneous phase followed by crystallizing the obtained lactone product in a solvent.
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title Process for lactonization in the preparation of statins
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