Method for enhancing T cell reactivity toward tumour antigens

Method for enhancing T cell reactivity toward tumour antigens

Provided is a method of vaccinating a patient against a tumor by administering an agent to reduce or prevent interaction between Notch and a Notch ligand, or expression or processing of Notch or a Notch ligand. In one embodiment, this is accomplished by administering to the patient a tumor antigen e...

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Hauptverfasser: Lamb, Jonathan Robert, Hoyne, Gerard Francis
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Sprache:eng
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creator Lamb, Jonathan Robert
Hoyne, Gerard Francis
description Provided is a method of vaccinating a patient against a tumor by administering an agent to reduce or prevent interaction between Notch and a Notch ligand, or expression or processing of Notch or a Notch ligand. In one embodiment, this is accomplished by administering to the patient a tumor antigen expressed by the tumor and exposing an antigen presenting cell in the patient to an agent that reduces or prevents interaction, expression or processing of Notch or a Notch ligand in a T cell.
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title Method for enhancing T cell reactivity toward tumour antigens
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