Human ADAM-10 inhibitors

Human ADAM-10 inhibitors

The present invention provides compounds useful for inhibiting the ADAM-10 protein, with selectivity versus MMP-1. Such compounds are useful in the in vitro study of the role of ADAM-10 (and its inhibition) in biological processes. The present invention also comprises pharmaceutical compositions com...

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Hauptverfasser: Bannen, Lynne Canne, Co, Erick W, Jammalamadaka, Vasu, Nuss, John M, Kim, Moon Hwan, Le, Donna Tra, Lew, Amy, Mamo, Shumeye, Wen, Zhaoyang, Xu, Wei
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creator Bannen, Lynne Canne
Co, Erick W
Jammalamadaka, Vasu
Nuss, John M
Kim, Moon Hwan
Le, Donna Tra
Lew, Amy
Mamo, Shumeye
Wen, Zhaoyang
Xu, Wei
description The present invention provides compounds useful for inhibiting the ADAM-10 protein, with selectivity versus MMP-1. Such compounds are useful in the in vitro study of the role of ADAM-10 (and its inhibition) in biological processes. The present invention also comprises pharmaceutical compositions comprising one or more ADAM-10 inhibitors according to the invention in combination with a pharmaceutically acceptable carrier. Such compositions are useful for the treatment of cancer, arthritis, and diseases related to angiogenesis. Correspondingly, the invention also comprises methods of treating forms of cancer, arthritis, and diseases related to angiogenesis in which ADAM-10 plays a critical role.
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title Human ADAM-10 inhibitors
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