Substituted diaza-spiro-[4.5]-decane derivatives and their use as neurokinin antagonists

Substituted diaza-spiro-[4.5]-decane derivatives and their use as neurokinin antagonists

1 12 13 123 This invention concerns substituted diaza-spiro-[4.5]-decane derivatives having neurokinin antagonistic activity, in particular NKantagonistic activity, a combined NK/NKantagonistic activity, a combined NK/NKantagonistic activity and a combined NK/NK/NKantagonistic activity, their prepar...

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Hauptverfasser: Janssens, Frans Eduard, Schoentjes, Bruno, Coupa, Sophie, Poncelet, Alain Philippe, Simonnet, Yvan René Ferdinand
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creator Janssens, Frans Eduard
Schoentjes, Bruno
Coupa, Sophie
Poncelet, Alain Philippe
Simonnet, Yvan René Ferdinand
description 1 12 13 123 This invention concerns substituted diaza-spiro-[4.5]-decane derivatives having neurokinin antagonistic activity, in particular NKantagonistic activity, a combined NK/NKantagonistic activity, a combined NK/NKantagonistic activity and a combined NK/NK/NKantagonistic activity, their preparation, compositions comprising them and their use as a medicine, in particular for the treatment and/or prophylaxis of schizophrenia, emesis, anxiety and depression, irritable bowel syndrome (IBS), circadian rhythm disturbances, pre-eclampsia, nociception, pain, in particular visceral and neuropathic pain, pancreatitis, neurogenic inflammation, asthma, chronic obstructive pulmonary disease (COPD) and micturition disorders such as urinary incontinence.The compounds according to the invention can be represented by general Formula (I) and comprises also the pharmaceutically acceptable acid or base addition salts thereof, the stereochemically isomeric forms thereof, the N-oxide form thereof and prodrugs thereof, wherein all substituents are defined as in Claim
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title Substituted diaza-spiro-[4.5]-decane derivatives and their use as neurokinin antagonists
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