Chiral, charged peptide nucleic acid oligomers from cyclic monomers

A novel class of peptide nucleic acid compounds, which are positively charged, chiral analogs based on cyclic monomeric units, bind to complementary ssDNA, dsDNA and RNA strands with more affinity than the corresponding achiral, linear peptide nucleic acids, without compromising the binding sequence...

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Hauptverfasser:	Kumar, Vaijayanti A, D'Costa, Moneesha, Ganesh, Krishnarajanagar N
Format:	Patent
Sprache:	eng
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creator	Kumar, Vaijayanti A D'Costa, Moneesha Ganesh, Krishnarajanagar N
description	A novel class of peptide nucleic acid compounds, which are positively charged, chiral analogs based on cyclic monomeric units, bind to complementary ssDNA, dsDNA and RNA strands with more affinity than the corresponding achiral, linear peptide nucleic acids, without compromising the binding sequence specificity and the compounds of this invention are more soluble in water than the standard peptide nucleic acids.
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title	Chiral, charged peptide nucleic acid oligomers from cyclic monomers
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