Pentalfluoroalkanesulfinyl naphthalenes and related estrogen receptor modulators

Pentalfluoroalkanesulfinyl naphthalenes and related estrogen receptor modulators

14 1 14 214 21 22 322 The present invention provides a compound of the formula (I) wherein R is -H, or -C-Calkyl; Ris -H, -OH, -O(C-Calkyl), -SO(C-Calkyl), or halo; X is -O-, -CH-, or -C(O)-; Xis -O- or -NR-; Ris -H or -CH; Y is -S-, -CHCH-, or -HC═CH-; m is 0, 1, 2, or 3; and n is 0 or 1; or a phar...

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Bibliographische Detailangaben
Hauptverfasser: Dodge, Jeffrey Alan, Hughes, Norman Earle
Format: Patent
Sprache:eng
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Zusammenfassung:14 1 14 214 21 22 322 The present invention provides a compound of the formula (I) wherein R is -H, or -C-Calkyl; Ris -H, -OH, -O(C-Calkyl), -SO(C-Calkyl), or halo; X is -O-, -CH-, or -C(O)-; Xis -O- or -NR-; Ris -H or -CH; Y is -S-, -CHCH-, or -HC═CH-; m is 0, 1, 2, or 3; and n is 0 or 1; or a pharmaceutically acceptable salt thereof; pharmaceutical compositions thereof; and methods for inhibiting a disease associated with an aberrant physiological response to endogenous estrogen.