Identification of biomarkers for liver toxicity

Identification of biomarkers for liver toxicity

The present invention relates to biomarker polypeptides, polynucleotides, and antibodies that have utility in predicting in vitro and/or in vivo hepatotoxicity of various drugs, compounds, or other therapeutic agents (i.e., test substances). Also related are screens, kits, microarrays, and cell cult...

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Hauptverfasser: Durham, Stephen K, Dambach, Donna, Hefta, Stanley, Moulin, Frederic, Gao, Ji, Opiteck, Gregory, Storm, Stephen M, Garulacan, Leah Ann, Lin, Jun-Hsiang
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creator Durham, Stephen K
Dambach, Donna
Hefta, Stanley
Moulin, Frederic
Gao, Ji
Opiteck, Gregory
Storm, Stephen M
Garulacan, Leah Ann
Lin, Jun-Hsiang
description The present invention relates to biomarker polypeptides, polynucleotides, and antibodies that have utility in predicting in vitro and/or in vivo hepatotoxicity of various drugs, compounds, or other therapeutic agents (i.e., test substances). Also related are screens, kits, microarrays, and cell culture systems that employ the polypeptides, polynucleotides, and/or antibodies of the invention. The reagents and methods of the invention are useful for predicting hepatotoxic effects resulting from treatment with one or more test substances, and can be utilized before, after, or concurrently with pre-clinical, clinical, and/or post-clinical testing. In this way, the reagents and methods of the invention can be used to identify test substances or combinations of test substances that cause hepatic injury, including idiosyncratic hepatotoxicity, and thereby prevent medical complications (e.g., liver failure) resulting from such injury.
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title Identification of biomarkers for liver toxicity
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