pH controlled fermentation process for pseudomonic acid production

pH controlled fermentation process for pseudomonic acid production

Pseudomonas An improved fermentation process for preparing pseudomonic acid A (mupirocin) is disclosed. The metabolically controlled fermentation process provides culturing a sp. strain in a submerged medium at a temperature within about 20-30° C. The pH of the fermentation medium is regulated to be...

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Hauptverfasser: Gulyas, Eva, Balogh, Gabor, Erdei, Janos, Seress, Peter
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creator Gulyas, Eva
Balogh, Gabor
Erdei, Janos
Seress, Peter
description Pseudomonas An improved fermentation process for preparing pseudomonic acid A (mupirocin) is disclosed. The metabolically controlled fermentation process provides culturing a sp. strain in a submerged medium at a temperature within about 20-30° C. The pH of the fermentation medium is regulated to be at about 5.5-6.0 by feeding the fermentation medium with an assimilable carbon source, a mineral salt, or an acidic/alkali solution. Accordingly, the resulting fermentation broth contains an increased yield of highly purified pseudomonic acid A as the main component. The pseudomonic acid B as an impurity in the fermentation broth is significantly decreased.
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title pH controlled fermentation process for pseudomonic acid production
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