Method for preparing imidazole derivatives

The present invention relates to methods for the prophylaxis, management and treatment of certain diseases modulated by the inhibition of the enzyme malonyl-coenzyme A decarboxylase (malonyl-CoA decarboxylase, MCD) by the administration of a composition containing as an active ingredient a compound...

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Hauptverfasser: Arrhenius, Thomas, Chen, Mi, Cheng, Jie Fei, Huang, Yujin, Nadzan, Alex Michael, Tith, Sovouthy, Haramura, Masayuki, Wallace, David Mark, Brown, Steve Joel, Harmon, Charles Stanford, Zhang, Lin, Lopaschuk, Gary D, Dyck, Jason R
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creator Arrhenius, Thomas
Chen, Mi
Cheng, Jie Fei
Huang, Yujin
Nadzan, Alex Michael
Tith, Sovouthy
Haramura, Masayuki
Wallace, David Mark
Brown, Steve Joel
Harmon, Charles Stanford
Zhang, Lin
Lopaschuk, Gary D
Dyck, Jason R
description The present invention relates to methods for the prophylaxis, management and treatment of certain diseases modulated by the inhibition of the enzyme malonyl-coenzyme A decarboxylase (malonyl-CoA decarboxylase, MCD) by the administration of a composition containing as an active ingredient a compound according to Formula I. In particular, the invention relates to methods for the prophylaxis, management and treatment of cardiovascular diseases, diabetes, acidosis, cancers, and obesity through the administration of a compound which inhibits malonyl-coenzyme A decarboxylase activity. The present invention also includes within its scope the novel process for the preparation of certain compounds
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In particular, the invention relates to methods for the prophylaxis, management and treatment of cardiovascular diseases, diabetes, acidosis, cancers, and obesity through the administration of a compound which inhibits malonyl-coenzyme A decarboxylase activity. 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title Method for preparing imidazole derivatives
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