Mutant cholera holotoxin as an adjuvant

A mutant cholera holotoxin featuring a point mutation at amino acid 29 of the A subunit, wherein the glutamic acid residue is replaced by an amino acid other than aspartic acid, is useful as an adjuvant in an antigenic composition to enhance the immune response in a vertebrate host to a selected ant...

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Bibliographische Detailangaben
Hauptverfasser: Holmes, Randall K, Jobling, Michael G, Eldridge, John H, Green, Bruce A, Hancock, Gerald E, Peek, Joel A
Format: Patent
Sprache:eng
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